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Last Updated: March 29, 2024

Claims for Patent: 8,142,792


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Summary for Patent: 8,142,792
Title:Extract of R. miehei
Abstract: Topical compositions comprising extracts of Rhizomucor miehei that are substantially devoid of acid-protease activity and their use in treating dermatologic conditions, including reducing the appearance of signs of skin aging.
Inventor(s): Bishop; Michael (Dallas, TX), Bishop; Elysiann (Dallas, TX), Gillis; Glen (Denton, TX)
Assignee: Active Organics, Inc. (Lewisville, TX)
Application Number:12/793,427
Patent Claims:1. A method for treating or reducing the appearance of fine lines and wrinkles on the skin comprising the steps of: administering to a person in need thereof a dermatocosmetic composition comprising a therapeutically-effective amount of a proteinaceous extract of Rhizomucor miehei substantially devoid of acid-protease activity, wherein the overall acid protease specific activity within the composition is less than about 500 HUT units/mg, and a dermatologically-acceptable carrier.

2. The method of claim 1, wherein the dermatocosmetic composition comprises an overall acid protease specific activity of less than about 50 HUT units/mg.

3. The method of claim 1, wherein the dermatocosmetic composition comprises has an overall acid protease specific activity of less than about 10 HUT units/mg.

4. A method for increasing levels of collagen in the skin comprising the steps of: administering to a person in need thereof a dermatocosmetic composition comprising a therapeutically-effective amount of a proteinaceous extract of Rhizomucor miehei substantially devoid of acid-protease activity, wherein the overall acid protease specific activity within the composition is less than about 500 HUT units/mg and a dermatologically-acceptable carrier.

5. The method of claim 4, wherein the overall protease specific activity is less than about 50 HUT units/mg.

6. The method of claim 4, wherein the overall acid protease specific activity less than about 10 HUT units/mg.

7. A method for stimulating collagen synthesis comprising the steps of: administering to a person in need thereof the a dermatocosmetic composition comprising a therapeutically-effective amount of a proteinaceous extract of Rhizomucor miehei substantially devoid of acid-protease activity, wherein the overall acid protease specific activity within the composition is less than about 500 HUT units/mg and a dermatologically-acceptable carrier.

8. A method for increasing the expression of one or more genes that code for collagen synthesis comprising the steps of administering to a person a dermatocosmetic composition comprising a therapeutically-effective amount of a proteinaceous extract of Rhizomucor miehei substantially devoid of acid-protease activity, wherein the overall acid protease specific activity within the composition is less than about 500 HUT units/mg and a dermatologically-acceptable carrier.

9. A method for decreasing the expression of one or more genes that code for collagenase comprising the steps of: administering to a person a dermatocosmetic composition comprising a therapeutically-effective amount of a proteinaceous extract of Rhizomucor miehei substantially devoid of acid-protease activity, wherein the overall acid protease specific activity within the composition is less than about 500 HUT units.mg and a dermatologically-acceptable carrier.

10. A method for increasing skin firmness comprising the steps of: administering to a person in need thereof a dermatocosmetic composition comprising a therapeutically-effective amount of a proteinaceous extract of Rhizomucor miehei substantially devoid of acid-protease activity, wherein the overall acid protease specific activity within the composition is less than about 500 HUT units/mg and a dermatologically-acceptable carrier.

11. The method of claim 10, wherein the overall acid protease specific activity is less than about 50 HUT units/mg.

12. The method of claim 10, wherein the overall acid protease specific activity is less than about 10 HUT units/mg.

13. A method for increasing skin moisture content comprising steps of: administering to a person in need thereof a dermatocosmetic composition comprising a therapeutically-effective amount of a proteinaceous extract of Rhizomucor miehei substantially devoid of acid-protease activity, wherein the overall acid protease specific activity within the composition is less than about 500 HUT units/mg and a dermatologically-acceptable carrier.

14. The method of claim 13 wherein the overall acid protease specific activity is less than about 500 HUT units/mg.

15. The method of claim 13, wherein the overall acid protease specific activity is less than about 50 HUT units/mg.

16. The method of claim 13, wherein the overall acid protease specific activity is less than about 10 HUT units/mg.

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