Claims for Patent: 8,128,933
✉ Email this page to a colleague
Summary for Patent: 8,128,933
Title: | Method of promoting bone growth by an anti-activin B antibody |
Abstract: | In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density. |
Inventor(s): | Knopf; John (Carlisle, MA), Seehra; Jasbir (Lexington, MA) |
Assignee: | Acceleron Pharma, Inc. (Cambridge, MA) |
Application Number: | 12/387,788 |
Patent Claims: | 1. A method for promoting bone growth, increasing bone density or increasing bone strength, the method comprising administering to a subject in need thereof an effective amount of an
anti-activin B antibody.
2. The method of claim 1, wherein the anti-activin B antibody is a humanized or fully human antibody. 3. A method for treating a bone-related disorder, the method comprising administering to a subject in need thereof an effective amount of an anti-activin B antibody, wherein the bone-related disorder is associated with low bone density or decreased bone strength. 4. The method of claim 3, wherein the method further comprising administering a second bone-active agent. 5. The method of claim 4, wherein the bone-active agent is selected from the group consisting of: a bisphosphonate, an estrogen, a selective estrogen receptor modulator, a parathyroid hormone, a calcitonin, a calcium supplement and a vitamin D supplement. 6. The method of claim 3, wherein the anti-activin B antibody is a humanized or fully human antibody. 7. The method of claim 3, wherein the bone-related disorder is primary osteoporosis. 8. The method of claim 3, wherein the bone-related disorder is secondary osteoporosis. 9. The method of claim 3, wherein the bone-related disorder is post-menopausal osteoporosis. 10. The method of claim 3, wherein the bone-related disorder is hypogonadal bone loss. 11. The method of claim 3, wherein the bone-related disorder is tumor-induced bone loss. 12. The method of claim 3, wherein the bone-related disorder is cancer therapy induced bone loss. 13. The method of claim 3, wherein the bone-related disorder is bony metastases. 14. The method of claim 3, wherein the bone-related disorder is multiple myeloma. 15. The method of claim 3, wherein the bone-related disorder is Paget's disease. 16. A method for promoting bone growth and inhibiting bone resorption in a patient in need thereof, the method comprising administering to the patient an effective amount of an anti-activin B antibody. 17. The method of claim 16, wherein the method causes less than 10% increase in the patient's skeletal muscle mass. 18. The method of claim 16, wherein the anti-activin B antibody is a humanized or fully human antibody. |
Details for Patent 8,128,933
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Nps Pharmaceuticals, Inc. | NATPARA | parathyroid hormone | For Injection | 125511 | 01/23/2015 | ⤷ Try a Trial | 2025-11-23 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.