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Last Updated: March 28, 2024

Claims for Patent: 8,080,249


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Summary for Patent: 8,080,249
Title:Methods to treating chronic obstructive pulmonary disease
Abstract: The present invention provides methods of treating a mammal having chronic obstructive pulmonary disease (COPD), independent of both smoking status and asthma status/with a therapeutically effective amount of an anti-IgE Enoiety. In accordance with the invention, COFD patients with sn elevated serum IgE level may benefit from the treatment methods disclosed. In certain instances, the methods of the disclosure have been found, to be useful ioE the treatment of COPD patients regardless of their skin test results arid/or in vitro reactivity to a perennial aeroallergen. Anti-EgE moieties, in accordance With the invention, include but are not limited to any IgG antibody that selectively binds to a given mammal iirunuitoglobulln E (e.g., human imntnnoglQbulin E) such as humanized arrti-IgEy humanized murine monoclonal antibody, and/or Qmalizumab.
Inventor(s): Risk; Glifford G. (Marlborough, MA)
Assignee:
Application Number:11/917,572
Patent Claims:1. A method of treating a mammal having COPD comprising administering to said mammal a composition consisting essentially of a therapeutically effective amount of an anti-IgE antibody; wherein the anti-IgE antibody blocks the binding of soluble IgE to its receptors; and wherein said administration results in an outcome comprising the treatment of acute exacerbation in the mammal.

2. The method according to claim 1, wherein the anti-IgE antibody is a humanized IgG antibody that selectively binds to human immunoglobulin E.

3. The method according to claim 2, wherein the humanized IgG antibody that selectively binds to human immunoglobulin E is a monoclonal antibody.

4. The method according to claim 1, wherein the anti-IgE antibody is omalizumab.

5. The method according to claim 1, wherein the mammal has an elevated serum IgE level.

6. The method according to claim 1, wherein the mammal has a negative skin test to an inhalant antigen.

7. The method according to claim 1, wherein the mammal has a negative in vitro reactivity to a perennial aeroallergen.

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