Unlock all Features See Plans and Pricing

Serving leading biopharmaceutical companies globally:

Johnson and Johnson
Harvard Business School
McKesson
Moodys
Medtronic
Boehringer Ingelheim

Last Updated: January 28, 2022

DrugPatentWatch Database Preview

Claims for Patent: 8,062,663

➤ Subscribe for complete access

« Back to Dashboard

Summary for Patent: 8,062,663
Title:Methods and compostions for enhancing transdermal drug delivery
Abstract: Methods and compositions for enhancing transdermal delivery of a bioactive agent. The method contains the step of applying to a skin tissue an effective amount of a composition comprising: (a) a drug vehicle; (b) a bioactive agent encapsulated within the drug vehicle; (c) a plurality of proteolytic enzyme molecules conjugated onto the surface of the drug vehicle; and (d) a pharmaceutically acceptable carrier, for a period of time effective to deliver the bioactive agent across the skin tissue at a desired dosage.
Inventor(s): Wang; Yu-Jing (Taichung, TW), Wang; Yu-Chao (Taipei, TW), Wu; Yi-Ting (Taoyuan, TW), Tai; Lin-Ai (Hsin-Chu, TW), Lo; Leu-Wei (Taipei, TW), Yang; Chung-Shi (Taichung, TW)
Assignee: National Health Research Instittues (Miaoli County, TW)
Application Number:12/466,011
Patent Claims:1. A method for enhancing delivery of a bioactive agent across a skin tissue comprising the step of: applying an effective amount of a composition comprising: a) a liposome; b) a bioactive agent encapsulated within the liposome; c) a plurality of proteolytic enzyme molecules conjugated onto the surface of the liposome; and d) a pharmaceutically acceptable carrier, for a period of time effective to deliver the bioactive agent across the skin tissue at a desired dosage.

2. The method of claim 1, wherein the composition further comprises a nanoparticle enclosed in the liposome, wherein the bioactive agent is encapsulated within the nanoparticle within the liposome.

3. The method of claim 2, wherein the nanoparticle is formed from poly(lactic-co-glycolic acid) (PLGA) or hydro-gel.

4. The method of claim 1, wherein the proteolytic enzyme is papain.

5. The method of claim 4, wherein the concentration of papain is less than 93, or less than 50, 40 or 30 .mu.g/ml.

6. The method of claim 1, wherein the proteolytic enzyme is a selected from the group consisting of papain, pancreatin, ficin, bromelain, elastase, pepsin, hyaluronidase, streptokinase, streptodornase, trypsin, chymotrypsin, .alpha.-chymotrypsin, .alpha.-amylase, deoxyribonuclease, collagenase, sutilain and any combination thereof.

7. The method of claim 1, wherein the bioactive agent comprises two or more than two types of bioactive agents.

8. The method of claim 7, wherein the two or more than two types of bioactive agents comprises at least one type of hydrophilic bioactive agent.

9. The method of claim 1, wherein the bioactive agent is a hormone.

10. A composition for transdermal administration of a bioactive agent comprising: a) a liposome; b) a bioactive agent encapsulated within the liposome; c) a plurality of proteolytic enzyme molecules conjugated onto the surface of the liposome; and d) a pharmaceutically acceptable carrier, wherein the proteolytic enzyme is selected from the group consisting of papain, pancreatin, ficin, bromelain, elastase, pepsin, hyaluronidase, streptokinase, streptodornase, trypsin, chymotrypsin, .alpha.-chymotrypsin, .alpha.-amylase, deoxyribonuclease, collagenase, sutilain and any combination thereof.

11. The composition of claim 10, wherein the enzyme is papain.

12. The composition of claim 11, wherein the concentration of papain is less than 93, or less than 50, 40 or 30 .mu.g/ml.

13. The composition of claim 10, wherein the composition further comprises a nanoparticle enclosed within the liposome, and wherein the bioactive agent is encapsulated within the nanoparticle within the liposome.

14. The composition of claim 13, wherein the nanoparticle is formed from poly(lactic-co-glycolic acid) (PLGA) nanoparticle or hydro-gel.

15. A composition for transdermal administration of a bioactive agent comprising: a) a liposome; b) a bioactive agent encapsulated within the liposome; c) a plurality of papain molecules conjugated onto the surface of the liposome; and d) a pharmaceutically acceptable carrier.

16. The composition of claim 15, wherein the concentration of papain is less than 93, or less than 50, 40 or 30 .mu.g/ml.

17. The composition of claim 15, wherein the composition further comprises a nanoparticle enclosed within the liposome, and wherein the bioactive agent is encapsulated within the nanoparticle within the liposome.

18. The composition of claim 17, wherein the nanoparticle is formed from poly(lactic-co-glycolic acid) (PLGA) nanoparticle or hydro-gel.

19. The method of claim 15, wherein the bioactive agent comprises two or more than two types of bioactive agents.

Details for Patent 8,062,663

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 2004-05-05 ⤷  Sign up for a Free Trial 2028-05-23
Bausch & Lomb Incorporated VITRASE hyaluronidase Injection 021640 2004-12-02 ⤷  Sign up for a Free Trial 2028-05-23
Amphastar Pharmaceuticals, Inc. AMPHADASE hyaluronidase Injection 021665 2004-10-26 ⤷  Sign up for a Free Trial 2028-05-23
Akorn, Inc. HYDASE hyaluronidase Injection 021716 2005-10-25 ⤷  Sign up for a Free Trial 2028-05-23
Smith & Nephew, Inc. SANTYL collagenase Ointment 101995 1965-06-04 ⤷  Sign up for a Free Trial 2028-05-23
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

Colorcon
Johnson and Johnson
AstraZeneca
Mallinckrodt
Moodys
Medtronic

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.