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Last Updated: January 28, 2022

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Claims for Patent: 8,057,792

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Summary for Patent: 8,057,792
Title:Use of an antibody that blocks TNF-alpha activity for treating a nerve disorder mediated by nucleus pulposus
Abstract: The present invention relates to a method and a pharmaceutical composition for treatment of nerve disorders comprising administration of a therapeutically effective dosage of at least two substances selected from the group consisting of TNF inhibitors, IL-1 inhibitors, IL-6 inhibitors, IL-8 inhibitors, FAS inhibitors, FAS ligand inhibitors, and IFN-gamma inhibitors. Preferably, at least one of the substances is a TNF inhibitor.
Inventor(s): Olmarker; Kjell (Molndal, SE), Rydevik; Bjorn (Goteborg, SE)
Assignee: Sciaticon AB (Molndal, SE)
Application Number:12/714,708
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 8,057,792
Patent Claims:1. A method of treating or alleviating one or more symptoms of a nerve disorder mediated by nucleus pulposus in a mammal comprising administering to the mammal a therapeutically effective amount of an antibody that blocks TNF-.alpha. activity, wherein the antibody is selected from the group consisting of murine monoclonal antibodies, chimeric antibodies, humanized antibodies and human monoclonal antibodies.

2. The method of claim 1, wherein the antibody that blocks TNF-.alpha. activity is a complete or intact antibody.

3. The method of claim 1, wherein the antibody that blocks TNF-.alpha. activity is selected from the group consisting of infliximab, CDP-571, D2E7 and CDP-870.

4. The method of claim 1, wherein the antibody that blocks TNF-.alpha. activity comprises an immunogenic fragment of an antibody which binds to an epitope of TNF-.alpha..

5. The method of claim 4, wherein the immunogenic fragment is selected from the group consisting of Fab fragments, scFv, and F(ab)2 fragments.

6. The method of claim 1, wherein the antibody is administered systemically.

7. The method of claim 1, wherein the antibody is administered orally.

8. The method of claim 1, wherein the antibody is administered intramuscularly.

9. The method of claim 1, wherein the antibody is administered intravenously.

10. The method of claim 1, wherein the antibody is administered locally.

11. The method of claim 1, wherein the antibody is administered epidurally.

12. The method of claim 1, wherein the nerve disorder involves pain.

13. The method of claim 1, wherein the nerve disorder is a nerve root injury.

14. The method of claim 1, wherein the nerve disorder presents as sciatica.

15. The method of claim 1, wherein the nerve disorder is caused by a herniated disc.

16. A method of treating or alleviating one or more symptoms of a herniated disc in a mammal comprising administering to the mammal a therapeutically effective amount of an antibody that blocks TNF-.alpha. activity, wherein the antibody is selected from the group consisting of murine monoclonal antibodies, chimeric antibodies, humanized antibodies and human monoclonal antibodies.

17. The method of claim 16, wherein the antibody that blocks TNF-.alpha. activity is a complete or intact antibody.

18. A method of treating or alleviating one or more symptoms of sciatica in a mammal comprising administering to the mammal a therapeutically effective amount of an antibody that blocks TNF-.alpha. activity, wherein the antibody is selected from the group consisting of murine monoclonal antibodies, chimeric antibodies, humanized antibodies and human monoclonal antibodies.

19. The method of claim 18, wherein the antibody that blocks TNF-.alpha. activity is a complete or intact antibody.

20. The method of claim 16 or 18, wherein the antibody that blocks TNF-.alpha. activity is selected from the group consisting of infliximab, CDP-571, D2E7 and CDP-870.

21. The method of claim 16 or 18, wherein the antibody that blocks TNF-.alpha. activity comprises an immunogenic fragment of an antibody which binds to an epitope of TNF-.alpha..

22. The method of claim 18, wherein the immunogenic fragment is selected from the group consisting of Fab fragments, scFv, and F(ab)2 fragments.

23. The method of claim 16 or 18, wherein the antibody is administered locally.

24. The method of claim 16 or 18, wherein the antibody is administered epidurally.

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