Claims for Patent: 8,057,496

Summary for Patent: 8,057,496

Title:	Mechanical thrombectomy device
Abstract:	A medical device for removing a thrombus from a blood vessel and a process thereof is presented. The device includes an outer sheath with a plurality of lumens. A wire guide inserted through one of the lumens is used to place the device proximate to a thrombus. A chemical lysing agent is used to at least partially lyse the thrombus. A wire basket extended through the first lumen proximate to the thrombus is translated back and forth to generate a force that may be transmitted to the partially lysed thrombus assisting in the formation of smaller fragments. A vacuum coupled to the distal end of the second lumen is used to remove the lysed thrombus fragments.
Inventor(s):	Fischer, Jr.; Frank J. (Bloomington, IN)
Assignee:	Cook Medical Technologies LLC (Bloomington, IN)
Application Number:	12/245,807
Patent Claims:	1. A medical device to partially lyse and remove a thrombus from a blood vessel, the device comprising: a tubular outer sheath having a first lumen and a second lumen with each lumen having a distal portion extending to a distal end and a proximal portion extending from the distal portion to a proximal end; a wire guide placed into the proximal end of the first lumen for delivery to a patient through the proximal end of the first lumen, an injector mechanism causing a lysing agent to flow through the second lumen; and a wire basket slidably received within the first lumen to replace the wire guide, the wire basket having a proximal end and a distal tip and comprising a plurality of wires, the plurality of wires extending helically from the proximal end to the distal tip; a vacuum applied through the second lumen to remove the at least partially lysed thrombus; the device being operable in two modes including a first delivery mode and a second mixing mode; wherein the wire basket is sized and extended proximate to the thrombus in said delivery mode; wherein the wire basket is caused to engage the thrombus to transmit force thereto in the furtherance of at least partially lysing and removing the thrombus in said mixing mode; wherein the wire basket is coupled to a control member that may be used by an operator to manipulate the wire basket; wherein the wire basket is collapsible and fits within the first lumen. 2. The device of claim 1, wherein the lysing agent is an antibody selected as one from a group of streptokinase, urokinase, plasmin, alteplase, tenecteplase, reteplase, and a tissue plasminogen activator. 3. The device of claim 1, wherein the lysing agent further comprises surface active polymers, emulsifying agents, anticoagulants, or a mixture thereof. 4. The device of claim 1, wherein the lysing agent is delivered as part of an isotonic or iso-osmotic solution. 5. The device of claim 4, wherein the isotonic solution is one selected from a group of saline, Ringer's solution, Krebs-Ringer's solution, and lactated Ringer's solution. 6. The device of claim 1, wherein the wire basket is comprised of at least three wires.

Details for Patent 8,057,496

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Microbix Biosystems Inc.	KINLYTIC	urokinase	For Injection	021846	01/16/1978		2039-02-26
Genentech, Inc.	ACTIVASE	alteplase	For Injection	103172	11/13/1987		2039-02-26
Genentech, Inc.	CATHFLO ACTIVASE	alteplase	For Injection	103172	09/04/2001		2039-02-26