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Last Updated: March 28, 2024

Claims for Patent: 8,053,412


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Summary for Patent: 8,053,412
Title:NELL-1 peptides
Abstract: Recombinant NELL peptides and methods of preparing the same are disclosed.
Inventor(s): Ting; Kang (Beverly Hills, CA), Kuroda; Shunichi (Osaka, JP), Wu; Ben (Los Angeles, CA)
Assignee: The Regents of the University of California (Oakland, CA)
Application Number:12/700,630
Patent Claims:1. A composition for inducing bone or cartilage formation comprising: an effective amount of a recombinant Nel-like molecule-1 (NELL-1) peptide comprising the amino acid sequence of SEQ ID NO:2 and a carrier, wherein the carrier comprises a physiologically acceptable compound carrier that forms an implant or scaffold that provides for bone or cartilage formation.

2. The composition of claim 1, wherein the NELL-1 peptide further comprises a NELL1 or NELL2 secretory peptide.

3. The composition of claim 1, wherein the carrier is a scaffold.

4. The composition of claim 1, which is in a formulation for injection into a fracture site or implantation.

5. The composition of claim 1, further comprising another agent.

6. The composition of claim 5, wherein the another agent is selected from the group consisting of a bone morphogenetic protein (BMP), a fibroblast growth factor (FGF), a transforming growth factor-.beta. (TGF-.beta.), an insulin-like growth factor (IGF), a vascular endothelial growth factor (VEGF), a platelet-derived growth factor (PDGF), a parathyroid hormone (PTH), a PTH-related protein (PTHrP), growth/differentiation factor 5 (GDF5); and LIM mineralization proteins (LMPs).

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