Claims for Patent: 8,034,765
✉ Email this page to a colleague
Summary for Patent: 8,034,765
Title: | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
Abstract: | The present invention provides stable pharmaceutical compositions of poorly water soluble pharmaceutical agents and stabilizing agents which function to increase stability of the compositions. The use of stabilizing agents provide extended stability of nanoparticle suspensions and other formulations of poorly water soluble pharmaceutical agents such as docetaxel under certain conditions, for example upon dilution for administration. |
Inventor(s): | De; Tapas (Los Angeles, CA), Desai; Neil P. (Los Angeles, CA), Yang; Andrew (Rosemead, CA), Yim; Zachary (Los Angeles, CA), Soon-Shiong; Patrick (Los Angeles, CA) |
Assignee: | Abraxis BioScience, LLC (Los Angeles, CA) |
Application Number: | 11/513,756 |
Patent Claims: | 1. A pharmaceutical composition comprising nanoparticles comprising docetaxel, wherein the nanoparticles comprise docetaxel coated with albumin, and wherein the
docetaxel used for preparation of the composition is in an anhydrous form.
2. The pharmaceutical composition according to claim 1, wherein the weight ratio of the albumin and docetaxel in the composition is about 18:1 or less. 3. The composition according to claim 1, further comprising a stabilizing agent. 4. The composition according to claim 3, wherein the stabilizing agent is a citrate. 5. The composition of claim 1, wherein the nanoparticles in the composition have an average or mean particle size of no greater than about 200 nm. 6. The composition of claim 5, further comprising a stabilizing agent. 7. The composition of claim 6, wherein the stabilizing agent is citrate. 8. The composition of claim 7, wherein the composition comprises about 200 mM sodium citrate and about 300 mM sodium chloride. 9. The composition of claim 1, wherein at least some of the docetaxel in the composition is in anhydrous form. 10. The composition of claim 4, wherein at least some of the docetaxel in the composition is in anhydrous form. 11. The composition of claim 7, wherein at least some of the docetaxel in the composition is in anhydrous form. 12. The composition according to claim 5, wherein the weight ratio of the albumin and docetaxel in the composition is about 18:1 or less. 13. The composition according to claim 5, wherein the albumin is human serum albumin. 14. The composition according to claim 5, wherein the pharmaceutical composition is sterile. 15. The composition according to claim 5, wherein the pharmaceutical composition is sterile filterable. 16. The composition according to claim 4, wherein the pharmaceutical composition further comprises sodium chloride. 17. The composition according to claim 7, wherein the pharmaceutical composition further comprises sodium chloride. 18. The composition according to claim 1, wherein the pharmaceutical composition is a liquid suspension. 19. The composition according to claim 17, wherein the composition is a liquid suspension of docetaxel at a concentration of at least about 1 mg/ml. 20. The pharmaceutical composition according to claim 5, wherein the pharmaceutical composition is a liquid suspension. 21. The composition according to claim 20, wherein the composition is a liquid suspension of docetaxel at a concentration of at least about 1 mg/ml. |
Details for Patent 8,034,765
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.