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Last Updated: April 19, 2024

Claims for Patent: 8,017,582

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Summary for Patent: 8,017,582

Title:	Immunostimulatory compositions and methods
Abstract:	The invention provides conjugates comprising an immune co-stimulatory polypeptide and an antigen or infectious agent. The conjugates are useful for generating or enhancing an immune response against the antigen or infectious agent. The invention also provides immune cells modified with a conjugate that are useful for generating or enhancing an immune response to an antigen or infectious agent. The invention also provides immunostimulatory moieties comprising an immune co-stimulatory polypeptide that are useful for stimulating an immune response. The invention also provides immunotherapy methods and methods of treating or preventing infections.
Inventor(s):	Shirwan; Haval (Louisville, KY), Elpek; Kutlu G. (Louisville, KY), Yolcu; Esma S. (Louisville, KY)
Assignee:	University of Louisville Research Foundation, Inc. (Louisville, KY)
Application Number:	12/553,770
Patent Claims:	1. A combination comprising: (a) a conjugate comprising a 4-1BBL immune co-stimulatory polypeptide and avidin or streptavidin; and (b) an antigen associated with an infectious agent. 2. The combination of claim 1, wherein said antigen is bound to said 4-1BBL conjugate. 3. The combination of claim 1, wherein said antigen is conjugated to a biotin moiety, to form an antigen-biotin conjugate. 4. The combination of claim 3, wherein said antigen-biotin conjugate is bound to said 4-1BBL conjugate via said biotin moiety. 5. The combination of claim 1, wherein said antigen is not bound to said 4-1BBL conjugate. 6. The combination of claim 1, wherein said infectious agent is a bacteria. 7. The combination of claim 6, wherein said bacteria is selected from the group consisting of Mycobacterium tuberculosis, Bacillus anthracis, and Staphylococcus aureus. 8. The combination of claim 1, wherein said infectious agent is a virus. 9. The combination of claim 8, wherein said virus is selected from the group consisting of Adenoviridae, Arenaviridae Caliciviridae, Coronaviridae, Filoviridae, Flaviviridae, Hepadnaviridae, Herpesviridae, Orthomyxoviridae, Papillomaviridae, Picornaviridae, Poxyiridae, Reoviridae, Retroviridae, Rhabdoviridae, and Togaviridae. 10. The combination of claim 1, wherein said infectious agent is a parasite. 11. The combination of claim 10, wherein said parasite is selected from the group consisting of Plasmodium and Leishmania. 12. The combination of claim 1, wherein said infectious agent is a fungus. 13. The combination of claim 12, wherein said fungus is selected from the group consisting of Aspergillis, Candida, Coccidia, Cryptococci, Geotricha, Histoplasma, Microsporidia, and Pneumocystis. 14. The combination of claim 1, further comprising a pharmaceutically acceptable excipient. 15. The combination of claim 1, wherein said 4-1BBL conjugate is provided in a container that also contains said antigen. 16. The combination of claim 1, wherein said 4-1BBL conjugate is provided in a separate container from said antigen. 17. The combination of claim 1, wherein said conjugate comprises the amino acid sequence of SEQ ID NO: 8.

Details for Patent 8,017,582

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Biodefense Operations Lansing Llc	BIOTHRAX	anthrax vaccine adsorbed	Injection	103821	11/12/1998	⤷ Try a Trial	2025-12-08
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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