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Last Updated: March 29, 2024

Claims for Patent: 8,006,698


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Summary for Patent: 8,006,698
Title:Aerosol therapy device
Abstract: The invention regards a therapeutic aerosol device in which a main aerosol flow, which is generated with the help of a compressed gas and is supplied to one of the nostrils of a user, is superimposed by pressure fluctuations. The superimposition of the pressure fluctuations occurs directly at one of the two nostrils of the user. A flow resistance is provided in the other nostril.
Inventor(s): Boehm; Andreas (Reichling, DE), Luber; Martin (Munich, DE), Rosenbeiger; Sven (Starnberg, DE)
Assignee: PARI GmbH Spezialisten fuer effektive Inhalation (Starnberg, DE)
Application Number:11/650,817
Patent Claims:1. Therapeutic aerosol device comprising a) a nebulizer device, to which a compressed gas can be supplied, having an aerosol generator for the generation of an aerosol which together with the supplied compressed gas forms a main aerosol flow, b) a nosepiece connected with the nebulizer device for supplying the aerosol to one of the two nostrils of the nose of a user, c) a flow resistance device for provision of a flow resistance in the other of the two nostril of the user, the flow resistance device having a first opening and a second opening, which is smaller than the first opening, and d) a connection device configured for connection to a device for generation of pressure fluctuations, the connection device being formed on the flow resistance device and being configured to introduce the pressure fluctuations into an interior of the flow resistance device between the first and second openings, and being configured to introduce the pressure fluctuations separately from the connection between the nebulizer device and the nosepiece, directly into the respective nostril of the user's two nostrils, such that the pressure fluctuations are superimposed on the main aerosol flow after separate introduction of the main aerosol flow and the pressure fluctuations into the respective nostril of the user to cause the aerosol from the main aerosol flow to reach the paranasal sinuses of the user and to be deposited therein.

2. Therapeutic aerosol device according to claim 1, wherein the flow resistance device comprises the connection device for the supply of pressure fluctuations which extend into the interior of the flow resistance device and further comprises a first opening for the connection of the interior with the nasal cavity of the user.

3. Therapeutic aerosol device according to claim 1, wherein the flow resistance device has a second opening which is designed such that the flow resistance is greater than the flow resistance of the natural flow path through the nasal cavity of the user.

4. Therapeutic aerosol device according to claim 2, wherein the second opening is formed in a wall of the flow resistance device which limits the interior of the flow resistance device.

5. Therapeutic aerosol device according to claim 1, wherein the flow resistance device comprises a stopper to be inserted into the nostril.

6. Therapeutic aerosol device according to claim 5, wherein the stopper is configured in the form of a truncated cone.

7. Therapeutic aerosol device according to claim 1, wherein the flow resistance device is connected by a connecting member with the nosepiece.

8. Therapeutic aerosol device according to claim 1, wherein the frequency of the pressure fluctuations lies within the range from 10 to 100 Hz.

9. Therapeutic aerosol device according to claim 1, wherein the pressure fluctuations are generated by means of a membrane compressor comprising a membrane that seals a pressure chamber in a pressure-tight way and is moved to and fro by a piston rod.

10. Therapeutic aerosol device according to claim 1, wherein the aerosol generator comprises a nebulizer nozzle having a compressed air channel opening up into the nozzle opening and having at least one suction channel through which a liquid to be nebulized is drawn in, the compressed gas supplied to the nebulizer device also effecting the generation of the aerosol.

11. Therapeutic aerosol device according to claim 1, wherein the aerosol generator comprises a membrane aerosol generator and the nebulizer device further comprises a supply device for the supply of the compressed gas to generate a main aerosol flow.

12. Therapeutic aerosol device according to claim 11, wherein the nebulizer device comprises a cylindrical tube piece which is disposed around the expansion spatial area in which the aerosol generated by the aerosol generator spreads, such that the supplied compressed gas impinges on outer sheath surface of the tube piece and flows on a front end into the interior of the tube piece.

13. Therapeutic aerosol device according to claim 12, wherein the cylindrical tube piece is disposed in one of the chambers surrounded by the nebulizer device such that a clearance is formed for the spread of the supplied compressed gas between an outer sheath surface of the cylindrical tube piece and an inner wall surface of the chamber.

14. Therapeutic aerosol device according to claim 12, wherein the front end of the cylindrical tube is located in front of the aerosol generator.

15. Therapeutic aerosol device according to claim 12, wherein the cylindrical tube piece has an annular cylindrical shape.

16. Therapeutic aerosol device according to claim 11, wherein the supply means for the compressed gas comprises a cylindrical connecting piece.

17. Therapeutic aerosol device according to claim 16, wherein the cylindrical connecting piece comprises an outlet directed at the cylindrical tube piece.

18. Therapeutic aerosol device according to claim 17, wherein supply means for the compressed gas comprises a connection device for the connection of a supply line for the compressed gas.

19. Therapeutic aerosol device claim 1, wherein the supply of the compressed gas takes place only at predetermined time intervals.

20. Therapeutic aerosol device according to claim 1, wherein an additional compressed gas flow is added to the supplied pressure fluctuations, which is smaller than the compressed gas flow for the generation of the main aerosol flow.

21. Therapeutic aerosol device according to claim 1, wherein diseases of the upper and lower respiratory tract can be specifically treated if these have a nasal or paranasal cause.

22. Therapeutic aerosol device according to claim 1, wherein the liquid medicinal formulations can thus be particularly advantageously deposited in the paranasal cavities in the form of an aerosol mist in order to treat diseases whose cause is there.

23. Therapeutic aerosol device according to claim 1, wherein, by targeted deposition of the active ingredients in the nose and paranasal cavities, diseases can be topically treated such as chronic or allergic sinusitis, inflammations or infections or other diseases or conditions ("atrophic rhinitis") so as by this means to avoid unwanted side effects or a symptomatic medical therapy.

24. Use of a therapeutic aerosol device according to claim 1, for the application of one or more of the following substances: substances selected from the group consisting of anti-inflammatory drugs, glucocorticoids, antiinfective agents, antibiotics, fungicides, virucides either alone or in combination with biofilm-reducing compounds or inhibitors of efflux pumps, antiseptics, immunomodulators, antioxidents, mycolytics, decongestives, vasoconstrictors, wound-treatment agents, local anesthesics, peptides, proteins and natural or synthetic plant extracts; steroidal active ingredients including glucocorticoids such as betamethasone, beclomethasone, budesonide, ciclesonide, dexamethasone, desoxymethasone, fluoconolone acetonide, flucinonide, flunisolide, fluticasone, icomethasone, rofleponide, triamcinolone acetonide, fluocortin butyl, hydrocortisone, hydroxycortisone-17-butyrate, prednicarbate, 6-methylprednisolone aceponate, mometasone furoate and non-steroidal anti-inflammatory drugs (NSAIDs) including prostaglandin, leukotriene, elastane, bradykinin antagonists, heparin and heparinoide, non-glucocorticoid steroides such as dehdroepiundrostendieone and dehdropianthrosterone (DHEA); any pharmaceutically acceptable salts, esters, isomers, stereoisomers, diasteriomers, epimeres, solvates or other hydrates, prodrugs, derivates or any other chemical or physical forms of the active ingredients which include the corresponding active units; antifective agents, the class or therapeutic category of which includes compounds which are effective against bacterial, fungoid and viral infections, including the classes of antimicrobial substances, the antibiotics, fungicides, antiseptics and virucides, either alone or in combination with biofilm-reducing or repressive agents and inhibitors of the efflux pump, including penicillins including benzylpenicillins (penicillin-G-sodium, clemizone penicillin, benzathine penicillin G), phenoxypenicillins (penicillin V, propicillin), aminobenzylpenicillins (ampicillin, amoxycillin, bacampicillin), acylaminopenicillins (azlocillin, mezlocillin, piperacillin, apalcillin), carboxypenicillins (carbenicillin, ticarcillin, temocillin), isoxazolyl penicillins (oxacillin, cloxacillin, dicloxacillin, flucloxacillin), amidine penicillin (mecillinam); cefalosporins including cefazolins (cefazolin, cefazedone); cefuroximes (cerufoxim, cefamdole, cefotiam); cefoxitins (cefoxitin, cefotetan, latamoxef, flomoxef); cefotaximes (cefotaxime, ceftriaxone, ceftizoxime, cefmenoxime); ceftazidimes (ceftadzidime, cefpirome, cefepime); cefalexins (cefalexin, cefaclor, cefadroxil, cefradine, loracarbef, cefprozil), and cefiximes (cefixime, cefpodoxim proxetile, cefuroxime axetil, cefetamet pivoxil, cefotiam hexetil), loracarbef, cefepim, clavulan acid/amoxicillin, ceftobiprole; synergists including beta-lactamase inhibitors, such as clavulan acids, sulbactam and tazobactam; cabapenems including imipenem, cilastin, meropenem, doripenem, tebipenem, ertapenem, ritipenam, and biapenem; monobactams including aztreonam; aminoglycosides including apramycin, gentamicin, amikacin, isepamicin, arbekacin, tobramycin, netilmicin, spectinomycin, streptomycin, capreomycin, neomycin, paromoycin and kanamycin; macrolides including erythromycin, clarythromycin, roxithromycin, azithromycin, dithromycin, josamycin, spiramycin and telithromycin; gyrase inhibitors or fluoroquinolones including ciprofloxacin, gatifloxacin, norfloxacin, ofloxacin, levofloxacin, perfloxacin, lomefloxacin, fleroxacin, garenoxacin, clinafloxacin, sitafloxacin, prulifloxacin, olamufloxacin, caderofloxacin, gemifloxacin, balofloxacin, trovafloxacin and moxifloxacin; tetracycline including tetracyclin, oxytetracyclin, rolitetracyclin, minocyclin, doxycycline, tigecycline and aminocycline; glycopeptides including vancomycin, teicoplanin, ristocetin, avoparcin, oritavancin, ramoplanin and Peptid 4; polypeptides including plectasin, dalbavancin, daptomycin, oritavancin, ramoplanin, dalbavancin, telavancin, bacitracin, tyrothricin, neomycin, kanamycin, mupirocin, paromomycin, polymyxin B and colistin; sulfonamides including sulfadiazine, sulfamethoxazole, sulfalene, co-trimoxazole, co-trimetrol, co-trimoxazine, co-tetraxazine; azoles including clotrimazole, oxiconazole, miconazole, ketoconazole, itraconazole, fluconazole, metronidazol, tinidazol, bifonazol, ravuconazol, posaconazol, voriconazol and ornidazol and other fungicides including flucytosin, griseofluvin, tonoftal, naftifin, terbinafin, amorolfin, ciclopiroxolamin, echinocundins, such as micafungin, caspofungin, anidulafungin; nitrofuranes including nitrofurantoin and nitrofuranzon; polyenes including amphotericin B, natamycin, nystatin, flucocytosin; other antibiotics including tithromycin, lincomycin, clindamycin, oxazolindione (linzezolide), ranbezolid, streptogramin A+B, pristinamycin aA+B, virginiamycin A+B, dalfopristin/giunupristin (synercide), chloramphenicol, ethambutol, pyrazinamid, terizidon, dapson, prothionamid, fosfomycin, fucidinic acids, rifampicin, isoniazide, cycloserine, terizidone, ansamycine, lysostaphin, iclaprim, mirocin B17, clerocidine, filgrastim, and pentamidin; virucides including aciclovir, ganciclovir, birivudin, valaciclovir, zidovudine, didanosin, thiacytidin, stavudin, lamivudin, zalcitabin, ribavirin, nevirapirin, delaviridin, trifluridin, ritonavir, saquinavir, indinavir, foscarnet, amantadin, podophyllotoxin, vidarabin, tromantadin and proteinase inhibitors; antiseptics including acridine derivatives, iodine providon, benzoates, rivanol, chlorohexetidine, quarternary ammonium compounds, cetrimides, biphenylol, clorofene and octenidine; plant extracts or components, including plant extracts of camomile, hamamelis, echiancea, calendula, papain, pelargonium, essential oils, myrtol, pinene, limonene, cineole, thymol, menthol, camphor, tannin, alpha-hederin, bisabol oil, lycopodin, vitapher oil; wound-treatment compounds including dexpanthenol, allantoin, vitamines, hyaluronic acid, alpha-antitrypsin, inorganic and organic zinc salts/compounds, bismuth salts, interferons (alpha, beta, gamma), tumor necrosis factors, cytokines, interleukines, immunomodulators including methotrexat, azathioprin, cyclosporin, tacrolimus, sirolimus, rapamycin, mofetil, cytostatic agents and metastases inhibitoren, alkylants, such as nimustin, melphanlan, carmustin, lomustin, cyclophosphosphamide, ifosfamide, trofosfamide, chloroambucile, busulfan, treosulfan, prednimustin, thiotepa; anti-metabolites including cytarabin, fluorouracil, methotrexat, mercaptopurin, tioguanin; alkaloids such as vinblastin, vincristin, vindesin; antibiotics such as alcarubicin, bleomycin, dactinomycin, daunorubicin, doxorubicin, epirubicin, idarubicin, mitomycin, plicamycin; complexes of two-group elements (Ti, Zr, V, Nb, Ta, Mo, W, Pt) such as carboplatinim, cis-platinum and metallocen compounds such as titanocen dichloride; amsacrin, dacarbazin, estramustin, etoposide, beraprost, hydroxycarbamide, mitoxanthron, procarbazin, temiposide; paclitaxel, iressa, zactima, poly-ADP-ribose-polymerase (PRAP) enzyme inhibitors, banoxantron, gemcitabin, pemetrexed, bevacizumab, ranibizumab; mycolytics including DNase, P2Y2-agonists (denufosol), heparinoide, guaifenesin, acetylcystein, carbocystein, aambroxol, bromhexin, tyloxapol, lecithine, myrtol, and recombined surfactant proteins; vasoconstrictors, which can be useful to reduce swelling of the mucous membrane, are including phenylephrine, naphazoline, tramazoline, tetryzoline, oxymetazoline, fenoxazoline, xylometazoline, epinephrine, isoprenaline, hexoprenaline and ephedrine; local anaesthetics containing benzocaine, tetracaine, procaine, lidocaine and bupivacaine; local antiallergics containing the above-mention glucocorticoids, cromolyn sodium, nedocromil, cetrizin, loratidine, montelukast, roflumilast, ziluton, omalizumab and heparinoids; peptides and proteins containing antibodies produced from microorganisms against toxins, antimicrobial peptides such as cecropine, defensine, thionine and cathelicidine; and combinations of any of the above-mentioned active ingredients, which consist of any pharmaceutically acceptable salt, ester, isomer, stereoisomer, diastereomer, epimer, solvate or other hydrate, prodrugs, derivative or any other chemical or physical form of active ingredients, which include the corresponding active units.

25. Use according to claim 24, wherein the application by the therapeutic aerosol device takes place in such a way that aerosol droplets with a diameter of less than 10 .mu.m are generated.

26. Use according to claim 24, wherein at least one of the substances is used as a liposome, suspension or emulsion in the micrometer range with a geometric diameter of less than 1 .mu.m.

Details for Patent 8,006,698

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Amgen, Inc. NEUPOGEN filgrastim Injection 103353 02/20/1991 ⤷  Try a Trial 2026-01-09
Amgen, Inc. NEUPOGEN filgrastim Injection 103353 06/28/2000 ⤷  Try a Trial 2026-01-09
Genentech, Inc. XOLAIR omalizumab For Injection 103976 06/20/2003 ⤷  Try a Trial 2026-01-09
Genentech, Inc. XOLAIR omalizumab Injection 103976 09/28/2018 ⤷  Try a Trial 2026-01-09
Hoffmann-la Roche Inc. PEGASYS COPEGUS COMBINATION PACK peginterferon alfa-2a and ribavirin 125083 06/04/2004 ⤷  Try a Trial 2026-01-09
Genentech, Inc. AVASTIN bevacizumab Injection 125085 02/26/2004 ⤷  Try a Trial 2026-01-09
Genentech, Inc. LUCENTIS ranibizumab Injection 125156 06/30/2006 ⤷  Try a Trial 2026-01-09
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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