Unlock all Features See Plans and Pricing

Serving leading biopharmaceutical companies globally:

Mallinckrodt
Johnson and Johnson
Medtronic
Baxter
Merck
AstraZeneca

Last Updated: January 29, 2022

DrugPatentWatch Database Preview

Claims for Patent: 7,947,270

➤ Subscribe for complete access

« Back to Dashboard

Summary for Patent: 7,947,270
Title:Removing dental plaque with krill enzymes
Abstract: The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about 40 kd as determined by SDS PAGE. Preferably, the multifunctional enzyme has substantial anti cell-cell adhesion activity. Preferably, the multifunctional enzyme has substantial homology with the krill multifunctional enzyme. These enzymes are useful for treating viral infections such as herpes outbreaks, fungal, bacterial or parasitic infections, including the primary and secondary infections of leprosy, colitis, ulcers, hemorrhoids, corneal scarring, dental plaque, acne, cystic fibrosis, blood clots, wounds, immune disorders including autoimmune disease and cancer. Additionally, the invention relates to a method of purifying the multifunctional enzyme, and to a preparation of essentially purified multifunctional enzyme.
Inventor(s): Franklin; Richard L. (London, GB)
Assignee: Arcimboldo AB (Stockholm, SE)
Application Number:10/750,184
Patent Claims:1. A method of removing dental plaque in mammals comprising the step of contacting the dental plaque with an effective amount of a hydrolytic enzyme composition comprising a mixture of enzymes isolated from Antarctic krill.

2. The method of claim 1, wherein the enzyme composition has endo-peptidase and exo-peptidase activities.

3. The method of claim 1, wherein the enzyme composition has at least two endo-peptidase activities and an exo-peptidase activity.

4. The method of claim 1, wherein the enzyme composition comprises enzymes having molecular weights between about 24 kd and about 34 kd as determined by SDS PAGE.

5. The method of claim 3, wherein the enzyme composition has at least three proteolytic activities selected from the group consisting of chymotrypsin activity, trypsin activity, collagenase activity and elastase activity.

6. The method of claim 3, wherein the enzyme composition has each of chymotrypsin activity, trypsin activity, collagenase activity and elastase activity.

7. The method of claim 1, wherein the mixture of enzymes is isolated from krill of a genus selected from Euphausia and Thysanoessa.

8. The method of claim 1, wherein the enzyme composition has a purity of at least about 95% with respect to macromolecules.

9. The method of claim 1, wherein the enzyme composition comprises enzymes having a molecular weight between about 20 kd and about 40 kd, as determined by SDS PAGE.

10. The method of claim 1, wherein the enzyme composition comprises a multifunctional enzyme.

11. The method of claim 10, wherein the multifunctional enzyme has at least one of a chymotrypsin, trypsin, collagenase, elastase or exo-peptidase activity.

12. The method of claim 11, wherein the multifunctional enzyme has at least two activities selected from the group consisting of chymotrypsin, activity, trypsin activity, collagenase activity, elastase activity and exo-peptidase activity.

13. The method of claim 1, wherein the enzyme composition comprises an enzyme which has an N-terminal sequence comprising IVGGM/NEVTPHAYPWQVGLFIDDMYF (SEQ ID NO: 17).

14. The method of claim 11, wherein the multifunctional enzyme has a molecular weight between about 26 kd and about 32 kd as determined by SDS PAGE.

15. A method of removing dental plaque in a mammal comprising: contacting the dental plaque with an effective amount of a poly-enzyme composition comprising enzymes isolated from Antarctic krill, and wherein said poly-enzyme composition comprises at least six proteins.

16. The method of claim 15, wherein the enzyme composition has endo- and exo-peptidase activities.

17. The method of claim 15, wherein the enzyme composition comprises enzymes having molecular weights between about 24 kd and about 34 kd as determined by SDS PAGE.

18. The method of claim 1, wherein the enzyme composition comprises a pharmaceutically acceptable topical carrier.

19. The method of claim 1, wherein the enzyme composition comprises a pharmaceutically acceptable carrier.

20. The method of claim 1, where the enzymes are isolated from Antarctic krill of the genus Euphausia.

Make Better Decisions: Try a trial or see plans & pricing

Serving leading biopharmaceutical companies globally:

McKinsey
Johnson and Johnson
McKesson
Colorcon
Dow
Moodys

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.