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Last Updated: April 20, 2024

Claims for Patent: 7,901,687

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Summary for Patent: 7,901,687

Title:	Antibodies for the detection of Bacillus anthracis and vaccine against B. anthracis infections
Abstract:	The present invention relates to conjugates of oligosaccharides of formula 1, wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides, 5 and which are useful for vaccination, methods of synthesis of such conjugates, antibodies against this antigen, hybridoma producing monoclonal antibodies against this antigen, assays using these antibodies for the detection of B. anthracis spores and kits comprising these antibodies, and a vaccine for the prevention of B. anthracis infection comprising the conjugates of oligosaccharides of formula 1. Monoclonal antibodies 10 according to the invention selectively bind to B. anthracis, but not to related bacteria such as B. subtilis, B. cereus and other bacteria of this group such as B. thuringiensis. ##STR00001##
Inventor(s):	Werz; Daniel B. (Gottingen, DE), Seeberger; Peter H. (Zurich, CH), Tamborrini; Marco (Basel, CH), Pluschke; Gerd (Bad Krozingen, DE)
Assignee:	Eth Zurich (Zurich, CH) Schweizerisches Tropeninstitut (Basel, CH)
Application Number:	12/226,728
Patent Claims:	1. The hybridoma cell MTA1 deposited at the "Deutsche Sammlung von Mikroorganismen and Zellkulturen GmbH (DSMZ)" on Jun. 15, 2006 under the number DSM ACC2792. 2. An isolated monoclonal antibody produced by the hybridoma cell MTA1 of claim 1 against a conjugate of an oligosaccharide of formula 1 ##STR00008## wherein R is a linker to a carrier protein and optionally comprises up to three further saccharides. 3. An assay reagent comprising an antibody according to claim 2 for the detection of Bacillus anthracis spores. 4. A kit comprising an antibody according to claim 2 for the detection of B. anthracis spores.

Details for Patent 7,901,687

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Emergent Biodefense Operations Lansing Llc	BIOTHRAX	anthrax vaccine adsorbed	Injection	103821	11/12/1998	⤷ Try a Trial	2026-06-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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