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Last Updated: July 5, 2020

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Claims for Patent: 7,884,196

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Summary for Patent: 7,884,196
Title:Vaccine composition comprising methylated DNA and immunomodulatory motifs
Abstract: The present invention relates generally to compositions and methods using mammalian, dsDNA (Double Stranded Deoxyribonucleic Acid) vaccination for the induction and maintenance of regulator suppressor T cells resulting in suppression of non infectious, and post infectious, inflammatory, allergic, auto-immune, vasculitic, certain degenerative vascular, and graft versus host diseases, with or without the use of IL-10, and with or without the use or TGF.beta., with or without the use of anti-IL 6 receptor antibody, anti TNF antibody and or Plasmapheresis, IVIG, Corticosteroids, Methotrexate, Bromocriptine, and or vitamin D analogues.
Inventor(s): Lawless; Oliver (Highland, MD)
Assignee: Lawless; Oliver (Olney, MD)
Application Number:11/244,142
Patent Claims:1. A vaccine composition for treating inflammatory, non infectious and/or post infectious, allergic, autoimmune, vasculitic, degenerative vascular, host v graft, graft v host diseases, Alzheimer's Disease, and amyloidosis comprising: a suppressor-regulator T cell activating amount of a synthetic, methylated DNA sequence of about 10 k to about 50 k Daltons, containing at least one SEQ ID NO 1 sequence and at least one SEQ ID NO 2 sequence.

2. The vaccine composition, according to claim 1, wherein said DNA is double-stranded.

3. The vaccine composition, according to claim 1, further comprising at least one agent selected from the group consisting of cytokines, antibodies, anti-TNF.alpha. biologics, and immunosuppressive agents.

4. The vaccine composition, according to claim 3, wherein said cytokine is chosen from the group consisting of IL-10 and TGF.beta.

5. The vaccine composition, according to claim 3, wherein said anti-TNF.alpha. biologics are chosen from the group consisting of Etanercept/Enbrel, Infliximab/Remicade, and Humira.

6. The vaccine composition, according to claim 3, wherein said immunosuppressive agent is chosen from the group consisting of Corticosteroids, Methotrexate, Bromocriptine, Immuran Cellcept, and vitamin D analogues.

7. A vaccine comprising: a suppressor-regulator T cell activating amount of a synthetic DNA molecule, said DNA molecule further comprising: At least one methylated region; at least one SEQ ID NO 1 sequence; and at least one SEQ ID NO 2 sequence.

Details for Patent 7,884,196

Applicant Tradename Biologic Ingredient Dosage Form BLA Number Approval Date Patent No. Assignee Estimated Patent Expiration Status Orphan Source
Centocor Inc REMICADE infliximab VIAL 103772 001 1998-08-24   Start Trial Lawless; Oliver (Olney, MD) 2024-10-06 RX Orphan search
Immunex ENBREL etanercept VIAL; SUBCUTANEOUS 103795 001 1998-11-02   Start Trial Lawless; Oliver (Olney, MD) 2024-10-06 RX Orphan search
Immunex ENBREL etanercept SYRINGE 103795 002 1998-11-02   Start Trial Lawless; Oliver (Olney, MD) 2024-10-06 RX Orphan search
Abbvie Inc HUMIRA adalimumab SYRINGE 125057 001 2002-12-31   Start Trial Lawless; Oliver (Olney, MD) 2024-10-06 RX search
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Number >Approval Date >Patent No. >Assignee >Estimated Patent Expiration >Status >Orphan >Source

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