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Last Updated: March 29, 2024

Claims for Patent: 7,851,179


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Summary for Patent: 7,851,179
Title:Method of measuring lipoarabinomannan and application thereof
Abstract: A method for measuring LAM and a method for detecting an acid-fast bacterium, which comprise at least a step of allowing a Limulus reagent to contact with a LAM-containing sample, a method for removing reactivity of LAM with a Limulus reagent, which comprises at least a step of allowing a predetermined substance to coexist with a LAM-containing sample; a method for measuring Et in a LAM-containing sample and a method for detecting an Et-related disease, which each is a method for measuring an endotoxin using a Limulus reagent, which comprises at least a step of removing reactivity of LAM with a Limulus reagent by the above-described removing method; a method for measuring BG in a LAM-containing sample and a method for detecting mycosis, which is a method for measuring BG using a Limulus reagent which comprises at least a step of removing reactivity of LAM with a Limulus reagent by the described-described removing method; and the like.
Inventor(s): Tanaka; Shigenori (Kodaira, JP), Takahashi; Shoji (Higashiyamato, JP)
Assignee: Seikagaku Corporation (Tokyo, JP)
Application Number:10/584,071
Patent Claims:1. A method for removing reactivity to a limulus reagent of lipoarabinomannan in a lipoarabinomannan-containing sample, comprising: allowing one or more substance(s) to coexist with said sample, wherein said substance is selected from the group consisting of: a surfactant, an anti-tuberculosis antibody, an anti-lipoarabinomannan antibody, a (1.fwdarw.3)-.beta.-glucan, a carboxymethylated (1.fwdarw.3)-.beta.-glucan, a factor G activation inhibitor, a strong alkaline substance, polymyxin B, colistin, concanavalin A, histidine and histamine.

2. A method for measuring an endotoxin in a lipoarabinomannan-containing sample, comprising: removing reactivity of lipoarabinomannan to a Limulus reagent by the method of claim 1; contacting said sample with a Limulus reagent; and detecting or measuring the Limulus reaction induced by said endotoxin.

3. The method according to claim 2, wherein the Limulus reagent is an endotoxin-specific Limulus reagent.

4. A method for detecting an endotoxin-related disease, which comprises detecting or measuring an endotoxin in a lipoarabinomannan-containing sample according to the method of claim 2.

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