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Last Updated: April 25, 2024

Claims for Patent: 7,846,449

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Summary for Patent: 7,846,449

Title:	Modified mite allergen and pharmaceutical uses thereof
Abstract:	The present invention provides a modified Dermatophagoides pteronyssinus allergen Der p 5 protein which has ability to inhibit IgE binding when exposed against to the antigen. A method for treating allergy comprising administrating a therapeutically effective dose of the modified D. pteronyssinus allergen Der p 5 protein to a subject suffering from allergy Der p 5 is also provided.
Inventor(s):	Hsu; Ching-Hsiang (Tainan County, TW), Su; Wei-Chih (Tainan County, TW)
Assignee:	Genmont Biotech Inc. (Tainan County, TW)
Application Number:	11/778,946
Patent Claims:	1. A method for reducing or alleviating symptoms of an allergic disease associated with Dermatophagoides pteronyssinus allergen Der p 5 comprising administering a therapeutically effective dose of a modified Der p 5 protein to a subject suffering from the allergic disease, wherein at least one of the amino acid residues 44, 77, 99 and 103 of wild-type D. pteronyssinus allergen Der p 5 protein of SEQ ID NO:2 is substituted with alanine in the modified Der p 5 protein. 2. A method for reducing or alleviating symptoms of an allergic disease associated with Dermatophagoides pteronyssinus allergen Der p 5 comprising administering a therapeutically effective dose of a modified Der p 5 protein to a subject suffering from the allergic disease, wherein the modified Der p 5 protein comprises an amino acid sequence selected from the group consisting of SEQ ID NOs: 4, 6 and 8.

Details for Patent 7,846,449

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Greer Laboratories, Inc.	N/A	insects (whole body), mite dermatophagoides pteronyssinus	Injection	101835	09/15/1958	⤷ Try a Trial	2040-01-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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