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Last Updated: March 28, 2024

Claims for Patent: 7,829,297


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Summary for Patent: 7,829,297
Title:Treatment of cancers expressing p95 ErbB2
Abstract: The truncated ErbB2 receptor (p95.sup.ErbB2) is shown to differ from the full-length ErbB2 receptor in its association with other ErbB receptors. The truncated receptor preferentially associated with ErbB3, whereas full length ErbB2 heterodimerizes with either EGFR or ErbB3. Consistent with p95.sup.ErbB2 heterodimerization with ErbB3, it is shown that heregulin (an ErbB3 ligand) stimulates p95.sup.ErbB2 phosphorylation in breast cancer cell lines. Described herein are methods of identifying patients suitable for treatment with a p95.sup.ErbB2 inhibitor, and methods of treating such patients.
Inventor(s): Spector; Neil Lee (Durham, NC), Xia; Wenle (Durham, NC)
Assignee: GlaxoSmithKline LLC (Philadelphia, PA)
Application Number:12/366,457
Patent Claims:1. A method of selecting therapy for a human subject having a solid epithelial tumor that overexpresses ErbB2, said method comprising: (a) determining whether said solid epithelial tumor expresses p95.sup.ErbB2; (b) if said solid epithelial tumor is determined in step (a) to express p95.sup.ErbB2, selecting a therapy that includes the administration of GW572016 for said human subject.

2. A method according to claim 1 where the expression of p95.sup.ErbB2 in tumor tissue is determined by immunohistochemical methods.

3. A method according to claim 1 where expression of p95.sup.ErbB2 is determined by measuring ErbB2 extracellular domain in a sample of the subject's serum.

4. A method according to claim 1 where said tumor is selected from breast, ovarian, colon, head and neck, bladder, renal cell and lung tumors.

5. A method according to claim 4 where said solid epithelial tumor is a breast tumor.

6. A method according to claim 1 where said subject has previously been treated with trastuzumab.

7. A method of selecting therapy for a human subject having a solid epithelial tumor that overexpresses ErbB2, said method comprising: (a) measuring the serum level of ErbB2 ECD of the subject to determine if said ECD level is elevated; (b) selecting a therapy that includes the administration of GW572016 for said human subject if said ECD level is elevated.

8. A method of selecting therapy for a human subject having a solid epithelial tumor that overexpresses ErbB2, said method comprising: (a) measuring p95.sup.ErbB2 levels is samples of said solid epithelial tumor to determine if p95.sup.ErbB2 overexpressed; (b) selecting a therapy that includes the administration of GW572016 for said human subject if p95.sup.ErbB2 is overexpressed.

Details for Patent 7,829,297

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Try a Trial 2023-08-01
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Try a Trial 2023-08-01
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 02/28/2019 ⤷  Try a Trial 2023-08-01
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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