Claims for Patent: 7,803,352
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Summary for Patent: 7,803,352
Title: | Method for continuous visualization of a blood clot or plaque in body lumen |
Abstract: | A method for visualizing a blood clot or plaque disposed within a body lumen comprising: binding a contrasting complex comprising a contrast material and a thrombolytic material or a clot dissolving agent to the blood clot or plaque; and visualizing the blood clot or plaque over a period time by a visualizing system. |
Inventor(s): | Fisher; John Steele (Belleair, FL) |
Assignee: | |
Application Number: | 10/982,990 |
Patent Claims: | 1. A method for selectively binding a contrasting complex to a blood clot or a thrombus on a plaque disposed within a body lumen comprising: administering an effective
amount of a contrasting complex comprising a contrast material and a thrombolytic material, wherein said contrasting complex: (i) binds or adheres to said blood clot or said thrombus disposed within said body lumen via a fibrin portion of said
thrombolytic material for a period of time sufficient to perform an invasive image-guided procedure, wherein said body lumen is selected from the group consisting of: the cardio-vascular system, the pulmonary system, the digestive system, the central
nervous system, the reproductive system, and the excretory system; (ii) provides real-time visualization of said blood clot or said thrombus by a visualizing system during said invasive image-guided procedure, wherein said visualizing system is selected
from the group consisting of: radiography systems, nuclear medicine systems, ultrasound systems, magnetic resonance systems and any combinations thereof; and (iii) exits said body without causing either kidney toxicity or stimulation of atherogenesis;
and visualizing said blood clot or said thrombus by said visualizing system, wherein said contrast material renders radio-opaque said blood clot or said thrombus under x-ray imaging, and wherein said thrombolytic material is selected from the group
consisting of: tissue plasminogen activator (tPA) tenecteplase form of TPAse, streptokinase, urokinase, retavase, and any mixtures thereof.
2. The method of claim 1, wherein said image-guided invasive procedure is selected from the group of: manipulation of wires, manipulation of balloons, manipulation of catheters, and manipulation of stents. 3. The method of claim 1, wherein said contrast material is selected from the group consisting of: an ionic material, non-ionic material and mixtures thereof. 4. The method of claim 1, wherein said contrast material comprises at least one heavy atom having an atomic weight of 30 or greater. 5. The method of claim 1, wherein said contrast material comprises at least one metal. 6. The method of claim 1, wherein said contrast material is selected from the group consisting of: iodine, gadolinium, ultrasound contrast materials, and mixtures thereof. 7. The method of claim 1, wherein said contrast material is selected from the group consisting of: metals, paramagnetic materials, high atomic number non-metal materials, radioisotopes, gases or gas precursors, chromatophores, fluorophores, electrical impedance materials, and any combinations thereof. 8. The method according to claim 1, wherein said contrast material binds to said thrombolytic material. 9. The method according to claim 8, wherein the bond between said contrast material and said thrombolytic material is selected from the group consisting of: a molecular bond, an ionic bond, covalent bond, metallic bond, mixed bonds, polar and nonpolar covalent bonds, and multiple bonds. |
Details for Patent 7,803,352
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Microbix Biosystems Inc. | KINLYTIC | urokinase | For Injection | 021846 | 01/16/1978 | ⤷ Try a Trial | 2023-03-07 |
Chiesi Usa, Inc. | RETAVASE | reteplase | For Injection | 103786 | 10/30/1996 | ⤷ Try a Trial | 2023-03-07 |
Genentech, Inc. | TNKASE | tenecteplase | For Injection | 103909 | 06/02/2000 | ⤷ Try a Trial | 2023-03-07 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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