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Last Updated: April 18, 2024

Claims for Patent: 7,786,288

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Summary for Patent: 7,786,288

Title:	Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site
Abstract:	The present invention relates to an immunogenic composition. More particularly, the present invention is a composition directed to eliciting an immune response to at least one binding site of Cyclophilin A on the HIV capsid protein. (SEQ ID NOS: 2, 4, and 6) The present invention contemplates three categories of embodiments: protein or protein fragments (SEQ ID NOS: 2, 4, and 6), messenger RNA, or DNA/RNA. DNA/RNA compositions (SEQ ID NOS 1, 3, 5, 7, 9, and 11) may be either naked or recombinant. The present invention further contemplates use with a variety of immune stimulants.
Inventor(s):	Karp; Nelson M. (Virginia Beach, VA)
Assignee:
Application Number:	10/971,199
Patent Claims:	1. An immunizing composition comprising, a nucleic acid encoding an HIV-1 capsid protein cyclophilin A (CypA) binding site selected from the group consisting of SEQ ID NOS: 1, 3, and 5 and a nucleic acid encoding a pharmaceutically acceptable carrier wherein said composition is capable of eliciting a Th-1 immune response to HIV-1. 2. A composition according to claim 1, wherein said nucleic acid encoding an HIV-1 capsid protein CypA binding site is present in a recombinant carrier capable of expressing said CypA binding site. 3. A composition according to claim 2, wherein said recombinant carrier is an avirulent virus. 4. A composition according to claim 3, wherein said virus is a herpes virus. 5. A composition according to claim 4, wherein said herpes virus is Epstein Barr virus. 6. A composition according to claim 3, wherein said virus is a poliovirus. 7. A composition according to claim 3, wherein said composition has been treated with neuraminidase, trypsin, or other appropriate enzyme to remove sialic acid. 8. A composition according to claim 2, wherein said recombinant carrier is bacteria. 9. A composition according to claim 8, wherein said bacteria is Bacillus Calmette-Guerin. 10. A composition according to claim 8, wherein said bacteria is Listeria monocytogenes. 11. A composition according to claim 8, wherein said composition has been treated with neuraminidase, trypsin, or other appropriate enzyme to remove sialic acid. 12. A composition according to claim 2, wherein said recombinant carrier is yeast. 13. A composition according to claim 12, wherein said yeast is Saccharomyces cerevisiae. 14. A method of eliciting an immune response in an animal, which comprises administering an immunizing composition comprising, a nucleic acid encoding an HIV-1 capsid protein cyclophilin A (CypA) binding site consisting of SEQ ID NOS: 1, 3, and 5; and a nucleic acid encoding a pharmaceutically acceptable carrier wherein said composition is capable of eliciting a Th-1 immune response to HIV-1. 15. A method according to claim 14, wherein the composition is administered, orally, transbucally, transmucosally, sublingually, nasally, rectally, vaginally, intraocularly, intramuscularly, intralymphatically, intravenously, subcutaneously, transdermally, intradermally, intra tumor, topically, transpulmonarily, by inhalation, by injection, or by implantation. 16. A method according to claim 14, wherein the composition is administered, by capsule, gelcap, tablet, enteric capsule, encapsulated particle, powder, suppository, injection, ointment, cream, implant, patch, liquid, inhalant, or spray. 17. A composition according to claim 1, wherein said composition is combined with an immune stimulant. 18. A composition according to claim 17, wherein said immune stimulant is an adjuvant. 19. A composition according to claim 17, wherein said immune stimulant comprises polysaccharides composed of at least one mannose in a form capable of binding to said composition. 20. A composition according to claim 17, wherein said immune stimulant comprises teichoic acid in a form capable of binding to said composition. 21. A composition according to claim 17, wherein said immune stimulant comprises zymosan in a form capable of binding to said composition. 22. A composition according to claim 17, wherein said immune stimulant comprises cryptococcus neoformans serotype C having a polysaccharide capsule capable of binding to said composition. 23. A composition according to claim 17, wherein said immune stimulant comprises protamine in a form capable of binding to heparin. 24. A composition according to claim 17, wherein said immune stimulant comprises a heparinase. 25. A composition according to claim 17, wherein said immune stimulant comprises cobra venom factor in a form adapted to enhance production of C3b. 26. A composition according to claim 25, wherein said cobra venom factor is dCVF. 27. A composition according to claim 17, wherein said immune stimulant comprises Nickel in a form adapted to enhance C3 convertase activity. 28. A composition according to claim 17, wherein said immune stimulant comprises sulfated polyanions capable of absorbing Factor H. 29. A composition according to claim 1, wherein polyanions within the composition capable of potentiating Factor H are substantially removed from the composition. 30. An immunizing composition comprising, a nucleic acid encoding an HIV-1 capsid protein cyclophilin A (CypA) binding site selected from the group comprising SEQ ID NOS: 1, 3, and 5; a nucleic acid encoding an adjuvant comprising cobra venom factor; and a nucleic acid encoding a pharmaceutically acceptable carrier, wherein said composition is capable of inducing an HIV-1 specific Th-1 immune response. 31. A composition according to claim 30, wherein said nucleic acid encoding an HIV-1 capsid protein CypA binding site is present in a recombinant carrier capable of expressing said HIV-1 capsid protein CypA binding site. 32. A composition according to claim 31, wherein said recombinant carrier is bacteria. 33. A composition according to claim 32, wherein said bacteria is Listeria monocytogenes. 34. A composition according to claim 30, wherein said cobra venom factor is dCVF.

Details for Patent 7,786,288

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Teknika Llc	TICE BCG	bcg live	For Injection	102821	06/21/1989	⤷ Try a Trial	2023-10-23
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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