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Last Updated: March 28, 2024

Claims for Patent: 7,785,780


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Summary for Patent: 7,785,780
Title:Assay for detecting and identifying micro-organisms
Abstract: An assay for detecting and identifying micro-organisms, particularly bacteria, is disclosed. In particular, an assay for detecting bacteria in a sample is disclosed. Bacteria are identified according to Gram-, genus- species- and strain-specificity based on multigenotypic testing of bacterial DNA from human, animal or environmental samples.
Inventor(s): Gala; Jean-Luc (Sint-Stevens-Woluwe, BE), Irenge; Leonid (Woluwe-St-Lambert, BE)
Assignee: Universite Catholique de Louvain (Louvain-la-Neuve, BE) La Defense Nationale (Brussels, BE)
Application Number:10/591,791
Patent Claims:1. An assay for detecting and identifying one or more bacteria in a sample, wherein said assay comprises detecting the presence or absence of at least two conserved molecular markers in the sample, thereby identifying one or more bacteria, wherein at least one molecular marker is conserved in Gram-positive bacteria and consists of SEQ ID NO: 14, and at least one molecular marker is conserved in Gram-negative bacteria and consists of SEQ ID NO: 230.

2. A method for diagnosing bacterial infection of a sample comprising screening the sample for the presence of at least two conserved molecular markers and diagnosing bacterial infection based on the presence of the at least two conserved molecular markers, wherein at least one molecular marker is conserved in Gram-positive bacteria and consists of SEQ ID NO: 14, and at least one molecular marker is conserved in Gram-negative bacteria and consists of SEQ ID NO: 230.

3. An assay for detecting and identifying Bacillus anthracis in a sample, wherein said assay comprises detecting the presence or absence of a conserved molecular marker in the sample, thereby identifying Bacillus anthracis, wherein said molecular marker consists of SEQ ID NO 14.

4. An assay for detecting and identifying Francisella tularensis in a sample, wherein said assay comprises detecting the presence or absence of a conserved molecular marker in the sample, thereby identifying Francisella tularensis, wherein said molecular marker consists of SEQ ID NO 230.

5. The method of claim 1, wherein the method further comprises detecting an additional molecular marker that is conserved in Gram-positive bacteria and which is selected from the group consisting of the sequences of SEQ ID NOs: 1-13, 15-62, and 326-359, and/or detecting an additional molecular marker that is conserved in Gram-negative bacteria and which is selected from the group consisting of SEQ ID NOs: 194-229, 231-232, 238-239, 242-254 and 431-442.

6. The method of claim 2, wherein the method further comprises detecting an additional molecular marker that is conserved in Gram-positive bacteria and which is selected from the group consisting of the sequences of SEQ ID NOs: 1-13, 15-62, and 326-359, and/or detecting an additional molecular marker that is conserved in Gram-negative bacteria and which is selected from the group consisting of SEQ ID NOs: 194-229, 231-232, 238-239, 242-254 and 431-442.

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