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Last Updated: April 19, 2024

Claims for Patent: 7,781,406

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Summary for Patent: 7,781,406

Title:	Production and use of the methotrexate-albumin conjugate as an immunosuppressive agent in GVHD
Abstract:	A method for modulating a transplantation-associated immune response in a subject is disclosed. The method comprises administering to the subject an effective amount of a conjugate comprising a carboxyl group-containing organic compound and albumin, wherein the carboxyl group-containing organic compound is a cytostatic or an immunosuppressant. A method for preparing the conjugate is also disclosed. The method includes activating the carboxyl group-containing organic compound with 1-ethyl-3-(3-dimethylaminopropyl) carbonyldiimide in an organic solvent, and reacting activated carboxyl group-containing organic compound with albumin, wherein the carboxyl group-containing organic compound is a cytostatic or an immunosuppressant.
Inventor(s):	Sinn; Hannsjorg (Wiesloch, DE)
Assignee:	Albupharm Heidelberg GmbH & Co. KG (Heidelberg, DE)
Application Number:	10/594,876
Patent Claims:	1. A method for preventing a transplantation-associated immune response in a subject, comprising: administering to said subject an effective amount of a conjugate comprising methotrexate and albumin at a methotrexate:albumin molar ratio of 0.9 to 1.1:1, wherein said transplantation is an organ transplantation selected from the group consisting of kidney, heart and liver transplantation. 2. The method of claim 1, wherein said transplantation-associated immune response is graft versus host disease (GVHD). 3. The method of claim 2, wherein said GVHD is an acute GVHD. 4. The method of claim 2, wherein said GVHD is a chronic GVHD. 5. The method of claim 1, wherein said transplantation is an allogeneic transplantation. 6. The method of claim 1, wherein said albumin is human albumin. 7. The method of claim 1, wherein said albumin is a native human albumin.

Details for Patent 7,781,406

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2024-04-02
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2024-04-02
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2024-04-02
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2024-04-02
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995	⤷ Try a Trial	2024-04-02
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	06/11/2003	⤷ Try a Trial	2024-04-02
Csl Behring Llc	ALBUMINAR, ALBUMINAR-20, ALBUMINAR-25, ALBUMINAR-5	albumin (human)	Injection	103955	03/17/2000	⤷ Try a Trial	2024-04-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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