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Last Updated: March 29, 2024

Claims for Patent: 7,732,163


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Summary for Patent: 7,732,163
Title:Extracellular serine protease
Abstract: The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
Inventor(s): O\'Brien; Timothy J. (Little Rock, AR), Underwood; Lowell J. (Little Rock, AR), Beard; John (Little Rock, AR), Shigemasa; Kazushi (Hiroshima, JP)
Assignee: Board of Trustees of The University of Arkansas (Little Rock, AR)
Application Number:10/652,846
Patent Claims:1. An isolated DNA that differs from the nucleic acid sequence of SEQ ID NO: 6 due to inclusion of an intron sequence between exon 2 and exon 3 of SEQ ID NO: 6, said DNA encoding a TADG-14 protein variant with an amino acid sequence shown in SEQ ID NO: 75.

2. A vector capable of expressing the DNA of claim 1, wherein said vector is adapted for expression in a cell and comprises regulatory elements necessary for expressing said DNA in said cell.

3. A host cell transfected with the vector of claim 2, wherein said vector expresses a TADG-14 protein variant with the amino acid sequence shown in SEQ ID NO: 75.

4. The host cell of claim 3, wherein said cell is a bacterial cell, a mammalian cell, a plant cell or an insect cell.

Details for Patent 7,732,163

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2017-08-21
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2017-08-21
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2017-08-21
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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