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Last Updated: April 25, 2024

Claims for Patent: 7,723,565

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Summary for Patent: 7,723,565

Title:	Vernalization-related molecules and methods for inducibly-conferring epigenetic changes
Abstract:	The invention provides vernalization-related polypeptides, nucleic acids and methods of using the same for inducibly-conferring epigenetic change on a target gene in plant or non-plant settings.
Inventor(s):	Amasino; Richard M. (Madison, WI), Sung; Si-Bum (Madison, WI), He; Yuehui (Madison, WI)
Assignee:	Wisconsin Alumni Research Foundation (Madison, WI)
Application Number:	10/905,520
Patent Claims:	1. An isolated nucleic acid selected from a group consisting of: (a) a nucleotide sequence encoding an amino acid sequence set forth in SEQ ID NO:3; (b) a nucleotide sequence set forth in SEQ ID NO:1; and (c) a nucleotide sequence set forth in SEQ ID NO:2. 2. A vector comprising the isolated nucleic acid according to claim 1. 3. A method of inducibly-conferring epigenetic repression on a target gene in a plant shoot or root apical meristem, comprising the steps of: (a) providing a plant containing: (1) the isolated nucleic acid encoding VIN3 according to claim 1 under control of an inducible promoter; and (2) a target gene comprising the nucleotide sequence set forth in SEQ ID NO:4 from Intron 1 of Flowering Locus C; and (b) inducing expression of said isolated nucleic acid encoding VIN3 whereby VIN3-mediated epigenetic repression of the target gene is effectuated. 4. The method according to claim 3 wherein repression of said target gene results in alleviation of a vernalization response in the plant. 5. The method according to claim 3 wherein said plant is a winter annual or a biennial plant. 6. The method according to claim 3 wherein said plant is a Cruciferous plant. 7. The method according to claim 3 wherein said target gene is Flowering Locus C (FLC).

Details for Patent 7,723,565

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132	06/04/1986	⤷ Try a Trial	2024-01-07
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	For Injection	103132		⤷ Try a Trial	2024-01-07
Merck Sharp & Dohme Corp.	INTRON A	interferon alfa-2b	Injection	103132		⤷ Try a Trial	2024-01-07
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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