Claims for Patent: 7,713,986

Summary for Patent: 7,713,986

Title:	Compounds and methods for treatment of chemotherapy-induced anemia
Abstract:	The invention relates to methods and compounds for treating chemotherapy-induced anemia. In particular, methods for treating chemotherapy-induced anemia in subjects refractory to treatment with recombinant human erythropoietin are encompassed herein.
Inventor(s):	Seeley; Todd W. (Moraga, CA), Liu; David Y. (Palo Alto, CA), Klaus; Stephen J. (San Francisco, CA)
Assignee:	FibroGen, Inc. (San Francisco, CA)
Application Number:	11/455,200
Patent Litigation and PTAB cases:	See patent lawsuits and PTAB cases for patent 7,713,986
Patent Claims:	1. A method for treating chemotherapy-induced anemia in a subject refractory to recombinant human EPO therapy, the method comprising the steps of determining whether the subject is refractory to recombinant human EPO therapy and administering to the subject an effective amount of an agent that inhibits hypoxia inducible factor (HIF) hydroxylase activity. 2. The method of claim 1, wherein the subject is undergoing chemotherapy. 3. The method of claim 1, wherein the subject has undergone chemotherapy. 4. The method of claim 1, wherein the subject is expected to undergo chemotherapy. 5. The method of claim 1, wherein the chemotherapy comprises administration of a chemotherapeutic selected from the group consisting of: an alkylating agent; a nitrosoureas; an antimetabolite; an anthracyclines; a topoisomerase II inhibitor; a mitotic inhibitor; an anti-estrogen; a progestin; an aromatase inhibitor; an anti-androgen; an LHRH agonist; a corticosteroid hormone; a DNA alkylating agent; a taxane; a vince alkaloid; and a microtubule poison. 6. The method of claim 1, wherein the chemotherapeutic is selected from the group consisting of busulfan, cisplatin, carboplatin, chlorambucil, cyclophosphamide, ifosfamide, dacarbazine (DTIC), mechlorethamine (nitrogen mustard), melphalan, temozolomide, carmustine (BCNU), lomustine (CCNU), 5-fluorouracil, capecitabine, 6-mercaptopurine, methotrexate, gemcitabine, cytarabine (ara-C), fludarabine, pemetrexed, daunorubicin, doxorubicin (Adriamycin), epirubicin, idarubicin, mitoxantrone, topotecan, irinotecan, etoposide (VP-16), teniposide, paclitaxel, docetaxel, vinbiastine, vincristine, vinorelbine, prednisone, dexamethasone, L-asparaginase, dactinomycin, thalidomide, tretinoin, imatinib (Gleevec), gefitinib (Iressa), erlotinib (Tarceva), rituximab (Rituxan), bevacizumab (Avastin), tamoxifen, fulvestrant, anastrozole, exemestane, letrozole, megestrol acetate, bicalutamide, flutamide, leuprolide, and goserelin. 7. The method of claim 1, wherein the agent is a 2-oxoglutarate mimetic. 8. The method of claim 1, wherein the agent is administered orally, systemically, intravenously, or by injection.

Details for Patent 7,713,986

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Recordati Rare Diseases, Inc.	ELSPAR	asparaginase	For Injection	101063	01/10/1978		2039-02-26
Genentech, Inc.	RITUXAN	rituximab	Injection	103705	11/26/1997		2039-02-26
Idec Pharmaceuticals Corp.	RITUXAN	rituximab	Injection	103737	02/19/2002		2039-02-26
Genentech, Inc.	AVASTIN	bevacizumab	Injection	125085	02/26/2004		2039-02-26