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Last Updated: March 28, 2024

Claims for Patent: 7,704,995


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Summary for Patent: 7,704,995
Title:Protein kinase modulators and methods of use
Abstract: This invention relates to compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion, and to pharmaceutical compositions containing such compounds. Even more specifically, the invention relates to compounds that inhibit, regulate and/or modulate kinases, particularly Checkpoint Kinases, even more particularly Checkpoint Kinase 1, or Chk1. Methods of therapeutically or prophylactically using the compounds and compositions to treat kinase-dependent diseases and conditions are also an aspect of the invention, and include methods of treating cancer, as well as other disease states associated with unwanted angiogenesis and/or cellular proliferation, by administering effective amounts of such compounds.
Inventor(s): Buhr; Chris A. (Redwood City, CA), Baik; Tae-Gon (Foster City, CA), Ma; Sunghoon (Foster City, CA), Tesfai; Zerom (Castro Valley, CA), Wang; Longcheng (Palo Alto, CA), Co; Erick Wang (Redwood City, CA), Epshteyn; Sergey (Fremont, CA), Kennedy; Abigail R (San Leandro, CA), Chen; Baili (Palo Alto, CA), Dubenko; Larisa (San Francisco, CA), Anand; Neel Kumar (San Mateo, CA), Tsang; Tsze H. (El Cerrito, CA), Nuss; John M. (Danville, CA), Peto; Csaba J (Alameda, CA), Rice; Kenneth D. (Mill Valley, CA), Ibrahim; Mohamed Abdulkader (Mountain View, CA), Schnepp; Kevin Luke (Elk Grove, CA), Shi; Xian (San Francisco, CA), Leahy; James William (San Leandro, CA), Chen; Jeff (San Francisco, CA), Dalrymple; Lisa Esther (San Francisco, CA), Forsyth; Timothy Patrick (San Mateo, CA), Huynh; Tai Phat (Oakland, CA), Mann; Grace (Brisbane, CA), Mann; Larry Wayne (Redwood City, CA), Takeuchi; Craig Stacy (Burlingame, CA), Lamb; Peter (Oakland, CA), Matthews; David J. (San Francisco, CA), Miller; Nicole (San Francisco, CA)
Assignee: Exelixis, Inc. (South San Francisco, CA)
Application Number:10/513,081
Patent Claims:1. A compound of Formula I, ##STR00227## or a pharmaceutically acceptable salt thereof, wherein, R.sup.1 is H; R.sup.2 is H and R.sup.3 is H or lower alkyl; R.sup.4 is --H or R.sup.5; R.sup.5 is selected from (1) lower alkyl; (2) aryl; (3) lower arylalkyl; (4) heterocyclyl; and (5) lower heterocyclylalkyl; or R.sup.4 and R.sup.5, when taken together with a common nitrogen to which they are attached, form a five- to seven-membered heterocyclyl, said five- to seven-membered heterocyclyl optionally containing at least one additional heteroatom selected from N, O, S, and P; Z is --N.dbd.; A is selected from --C(.dbd.O)--, --C(.dbd.S)--, --C(.dbd.NR.sup.6)--, and --R.sup.7, when A is --R.sup.7, E does not exist; R.sup.6 is selected from (1) --H; (2) --NO.sub.2; (3) --N(R.sup.2)R.sup.3; (4) N(H)C(.dbd.NR.sup.2)N(R.sup.2)R.sup.3; (5) --CN; (6) --OR.sup.4; (7) lower alkyl; (8) heteroalicyclylalkyl; (10) arylalkyl; (11) alkoxy; and (12) heteroalicyclic; R.sup.7 is a five- to seven-membered heterocyclyl, said five- to seven-membered heterocyclyl optionally containing at least one additional heteroatom selected from N, O, S, and P; E is selected from Table 2: TABLE-US-00013 TABLE 2 ##STR00228## ##STR00229## ##STR00230## ##STR00231## ##STR00232## ##STR00233## ##STR00234## ##STR00235## ##STR00236## ##STR00237## ##STR00238## ##STR00239## ##STR00240## ##STR00241## ##STR00242## ##STR00243## ##STR00244##

wherein each R.sup.16 is independently selected from (1); --H, (2) lower alkyl; (3) --CO.sub.2R.sup.4, and (4) --C(.dbd.O)R.sup.4; or two of R.sup.16, together with the nitrogen or nitrogens to which they are attached, form a heterocyclic ring; each R.sup.17 is independently selected from (1) --H; (2) halogen; (3) oxo; (4) --CN; (5) --NH.sub.2; (6) --CF.sub.3; (7) --NO.sub.2; (8) --OR.sup.4; (9) --N(R.sup.4)R.sup.5; (10) --S(O).sub.0-2R.sup.5; (11) --SO.sub.2N(R.sup.4)R.sup.5; (12) --CO.sub.2R.sup.4; (13) --C(O)N(R.sup.4)R.sup.5; (14) --N(R.sup.4)SO.sub.2R.sup.5; (15) --N(R.sup.4)C(O)R.sup.5; (16) --N(R.sup.4)CO.sub.2R.sup.5; (17) --C(O)R.sup.4; (18) lower alkyl; (20) arylalkyl; (21) heterocyclyl; and (22) lower heterocyclylalkyl; and R.sup.18 is lower alkyl; W is either (1) a six- to ten-membered arylene or (2) a five- to ten-membered heteroarylene; X is selected from a single bond; --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--; --(CH.sub.2).sub.0-3CO.sub.2(CH.sub.2).sub.0-3--; --(CH.sub.2).sub.0-3SO.sub.2N(R.sup.4)(CH.sub.2).sub.0-3--; --N(R.sup.4)(CH.sub.2).sub.2-3O--; --(CH.sub.2).sub.0-3 N(R.sup.4)C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--; --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.2-3O--; --(CH.sub.2).sub.0-3S(O).sub.0-2(CH.sub.2).sub.0-3--; --N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--; --(CH.sub.2).sub.0-3C(=O)N(R.sup.4)(CH.sub.2).sub.1-3C(.dbd.O)--; --(CH.sub.2).sub.0-3OC(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--; --C(.dbd.O)N(R.sup.4)N(R.sup.4)--; --(CH.sub.2).sub.0-3CO.sub.2(CH.sub.2).sub.2-3N(R.sup.4)--; --(CH.sub.2).sub.0-3N(R.sup.4)C(.dbd.O)(CH.sub.2).sub.0-3O--; --(CH.sub.2).sub.0-3N(R.sup.4)(CH.sub.2).sub.0-3--; --C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--; --O(CH.sub.2).sub.2-3O; --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.2-3S(O).sub.0-2--; --(CH.sub.2).sub.0-3N(R.sup.4)C(.dbd.O)(CH.sub.2).sub.0-3S(O).sub.0-2--; --(CH.sub.2).sub.0-3O(CH.sub.2).sub.0-3--; alkoxyl; and lower alkylene; and Y is selected from (1) lower alkyl substituted with one or more aryl; (2) aryl; (3) and heterocyclyl or Y is selected from Table 1: TABLE-US-00014 TABLE 1 ##STR00245## ##STR00246## ##STR00247## ##STR00248## ##STR00249## ##STR00250## ##STR00251## ##STR00252## ##STR00253## ##STR00254## ##STR00255## ##STR00256## ##STR00257## ##STR00258## ##STR00259## ##STR00260## ##STR00261## ##STR00262## ##STR00263## ##STR00264## ##STR00265## ##STR00266##

wherein each R.sup.15 is independently selected from (1) --H; (2) halogen; (3) --CN; (4) --NH.sub.2; (5) --CF.sub.3; (6) --NO.sub.2; (7) --OR.sup.4; (8) --N(R.sup.4)R.sup.5; (9) --S(O).sub.0-2R.sup.5; (10) --SO.sub.2N(R.sup.4)R.sup.5; (11) --CO.sub.2R.sup.4; (12) --C(O)N(R.sup.4)R.sup.5; (13) --N(R.sup.4)SO.sub.2R.sup.5; (14) --N(R.sup.4)C(O)R.sup.5; (15) --N(R.sup.4)CO.sub.2R.sup.5; (16) --C(O)R.sup.4; (17) lower alkyl; (18) aryl; (19) lower arylalkyl; (20) heterocyclyl; and (21) lower heterocyclylalkyl.

2. The compound according to claim 1, wherein R.sup.2 and R.sup.3 are --H.

3. The compound according to claim 2, wherein A is R.sup.7, and R.sup.7 is either ##STR00267## wherein each G.sup.1 is independently .dbd.N-- or .dbd.C(R.sup.11)--, L is selected from --O--, --S(O).sub.0-2--, and --NR.sup.11, wherein each R.sup.11 is independently selected from (1) --H, (2) halogen, (3) --CN, (4) --NH.sub.2, (5) --CF.sub.3, (6) --NO.sub.2, (7) --OR.sup.4, (8) --N(R.sup.4)R.sup.5, (9) --S(O).sub.0-2R.sup.5, (10) --SO.sub.2N(R.sup.4)R.sup.5, (11) --CO.sub.2R.sup.4, (12) --C(O)N(R.sup.4)R.sup.5, (13) --N(R.sup.4)SO.sub.2R.sup.5, (14) --N(R.sup.4)C(O)R.sup.5, (15) 2-N(R.sup.4)CO.sub.2R.sup.5, (16) --C(O)R.sup.4, (17) lower alkyl (18) aryl; (19) lower arylalkyl; (20) heterocyclyl; and (21) lower heterocyclylalkyl.

4. The compound according to claim 3, wherein R.sup.7 is selected from ##STR00268## wherein R.sup.11a is selected from --H, lower alkyl; ##STR00269## wherein each R.sup.12 is independently selected from (1) --H, (2) halogen, (3) oxo, (4) --CN, (5) --NH.sub.2, (6) --CF.sub.3, (7) --NO.sub.2, (8) --OR.sup.4, (9) --N(R.sup.4)R.sup.5, (10) --S(O).sub.0-2R.sup.5, (11) --SO.sub.2N(R.sup.4)R.sup.5, (12) --CO.sub.2R.sup.4, (13) --C(O)N(R.sup.4)R.sup.5, (14) --N(R.sup.4)SO.sub.2R.sup.5, (15) --N(R.sup.4)C(O)R.sup.5, (16) --N(R.sup.4)CO.sub.2R.sup.5, (17) --C(O)R.sup.4, (18) lower alkyl; (19) aryl; (20) lower arylalkyl; (21) Heterocyclyl; and (22) lower heterocyclylalkyl; R.sup.13 is selected from --H, and lower alkyl; Q is either .dbd.N-- or .dbd.C(R.sup.12)--; and M is selected from --O--, --S(O).sub.0-2--, and --NR.sup.13.

5. The compound according to claim 4, wherein W is ##STR00270## wherein each G.sup.2 is independently .dbd.N--or .dbd.C(R.sup.14)--, and each R.sup.14 is independently selected from (1) --H; (2) halogen; (3) --CN; (4) --NH.sub.2; (5) --CF.sub.3; (6) --NO.sub.2; (7) --OR.sup.4; (8) --N(R.sup.4)R.sup.5; (9) --S(O).sub.0-2R.sup.5; (10) --SO.sub.2N(R.sup.4)R.sup.5; (11) --CO.sub.2R.sup.4; (12) --C(O)N(R.sup.4)R.sup.5; (13) --N(R.sup.4)SO.sub.2R.sup.5; (14) --N(R.sup.4)C(O)R.sup.5; (15) --N(R.sup.4)CO.sub.2R.sup.5; (16) --C(O)R.sup.4; (17) lower alkyl; (18) aryl; (19) lower arylalkyl; (20) heterocyclyl; and (21) lower heterocyclylalkyl.

6. The compound according to claim 5, wherein W is ##STR00271##

7. The compound according to claim 6, wherein X is selected from (1) --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--; (2) --(CH.sub.2).sub.0-3SO.sub.2N(R.sup.4)(CH.sub.2).sub.0-3--; (3) --N(R.sup.4)(CH.sub.2).sub.2-3; (4) --(CH.sub.2).sub.0-3N(R.sup.4)C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--; (5) --C(.dbd.O)N(R.sup.4)N(R.sup.4)--; (6) --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.2-3O--; (7) --N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--; (8) --(CH.sub.2).sub.0-3N(R.sup.4)(CH.sub.2).sub.0-3; (9) --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.1-3C(.dbd.O)--; (10) --O(CH.sub.2).sub.2-3O--; (11) --(CH.sub.2).sub.0-3OC(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--; (12) --(CH.sub.2).sub.0-3O(CH.sub.2).sub.0-3--; (13) --(CH.sub.2).sub.0-3CO.sub.2(CH.sub.2).sub.2-3N(R.sup.4)--; (14) --(CH.sub.2).sub.0-3N(R.sup.4)C(.dbd.O)(CH.sub.2).sub.0-3O--; (15) --C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--; (16)alkoxyl and (17) lower alkylene.

8. The compound according to claim 7, wherein X is selected from (1) --C(.dbd.O)N(H)(CH.sub.2).sub.1-2--; (2) --(CH.sub.2).sub.1-2C(.dbd.O)N(H)--; (3) --C(.dbd.O)N(H)--; (4) --SO.sub.2N(H)(CH.sub.2).sub.1-2--; (5) --(CH.sub.2).sub.1-2SO.sub.2N(H)--; (6) --SO.sub.2N(H)--; (7) --N(H)C(.dbd.O)N(H)(CH.sub.2).sub.1-2--; (8) --N(H)C(.dbd.O)N(H)--; (9) --(CH.sub.2).sub.0-2N(R.sup.4)(CH.sub.2).sub.0-2--; (10) --(CH.sub.2).sub.0-2O(CH.sub.2).sub.0-2; (11) --C(.dbd.O)N(H)N(H)--; (12) --N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--; (13) --OCH.sub.2C(.dbd.O)N(H)CH.sub.2--; (14) --(CH.sub.2).sub.1-2N(H)C(.dbd.O)N(H)--; (15) --OCH.sub.2CH.sub.2O--; --N(R.sup.4)CH.sub.2C(.dbd.O)N(H)CH.sub.2--; (16) --(CH.sub.2).sub.0-1C(.dbd.O)N(H)(CH.sub.2).sub.1-2C(.dbd.O)--; and (17) alkoxyl.

9. The compound according to claim 8, wherein Y is selected from phenyl; and a five- to six-membered heterocyclyl.

10. The compound according to claim 9, wherein R.sup.11b is selected from (1) alkyl; (2) phenyl; (3) pyridyl; (4) morpholinyl; (5) pyrrolidinyl; (6) piperidinyl; and (7) azepanyl.

11. The compound according to claim 10, wherein R.sup.7 is ##STR00272##

12. The compound according to claim 4, wherein R.sup.11b is ##STR00273## wherein R.sup.14 is either --H or lower alkyl.

13. The compound according to claim 11, wherein R.sup.11b is a pyridyl group.

14. The compound according to claim 4, wherein R.sup.11b is a pyridyl group bearing a 2-amino group.

15. The compound according to claim 1, wherein A is --C(.dbd.O)-- or --C(.dbd.NR.sup.6)--.

16. The compound according to claim 15, wherein A is --C(.dbd.O)--.

17. The compound according to claim 16 wherein W is ##STR00274## wherein each G.sup.2 is independently .dbd.N--or .dbd.C(R.sup.14)--; wherein each R.sup.14 is independently selected from (1) --H; (2) halogen; (3) --CN; (4) --NH.sub.2; (5) --CF.sub.3; (6) --NO.sub.2; (7) --OR.sup.4; (8) --N(R.sup.4)R.sup.5; (9) --S(O).sub.0-2R.sup.5; (10) --SO.sub.2N(R.sup.4)R.sup.5; (11) --CO.sub.2R.sup.4; (12) --C(O)N(R.sup.4)R.sup.5; (13) --N(R.sup.4)SO.sub.2R.sup.5; (14) --N(R.sup.4)C(O)R.sup.5; (15) --N(R.sup.4)CO.sub.2R.sup.5; (16) --C(O)R.sup.4; (17) lower alkyl; (18) aryl; (19) lower arylalkyl; (20) heterocyclyl; and (21) lower heterocyclylalkyl.

18. The compound according to claim 17, wherein W is ##STR00275##

19. The compound according to claim 18, wherein X is selected from --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--, --(CH.sub.2).sub.0-3SO.sub.2N(R.sup.4)(CH.sub.2).sub.0-3, --N(R.sup.4)(CH.sub.2).sub.2-3O, --(CH.sub.2).sub.0-3N(R.sup.4)C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--, --C(.dbd.O)N(R.sup.4)N(R.sup.4)--, --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.2-3O--, --N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--, --(CH.sub.2).sub.0-3N(R.sup.4)(CH.sub.2).sub.0-3--, --(CH.sub.2).sub.0-3C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.1-3C(.dbd.O)--, --O(CH.sub.2).sub.2-3O--, --(CH.sub.2).sub.0-3OC(.dbd.O)N(R.sup.4)(CH.sub.2).sub.0-3--, --(CH.sub.2).sub.0-3O(CH.sub.2).sub.0-3--, --(CH.sub.2).sub.0-3CO.sub.2(CH.sub.2).sub.2-3N(R.sup.4)--, --(CH.sub.2).sub.0-3N(R.sup.4)C(.dbd.O)(CH.sub.2).sub.0-3O--, --C(.dbd.O)N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--, alkoxyl, and lower alkylene.

20. The compound according to claim 19, wherein X is selected from --C(.dbd.O)N(H)(CH.sub.2).sub.1-2--, --(CH.sub.2).sub.1-2C(.dbd.O)N(H)--, --C(.dbd.O)N(H)--, --SO.sub.2N(H)(CH.sub.2).sub.1-2, --(CH.sub.2).sub.1-2SO.sub.2N(H)--, --SO.sub.2N(H)--, --N(H)C(.dbd.O)N(H)(CH.sub.2).sub.1-2--, --N(H)C(.dbd.O)N(H)--, --(CH.sub.2).sub.0-2N(R.sup.4)(CH.sub.2).sub.0-2--, --(CH.sub.2).sub.0-2O(CH.sub.2).sub.0-2, --C(.dbd.O)N(H)N(H)--, --N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--, --OCH.sub.2C(.dbd.O)N(H)CH.sub.2--, --(CH.sub.2).sub.1-2N(H)C(.dbd.O)N(H)--, --OCH.sub.2CH.sub.2O--, --N(R.sup.4)CH.sub.2C(.dbd.O)N(H)CH.sub.2--, --(CH.sub.2).sub.0-1C(.dbd.O)N(H)(CH.sub.2).sub.1-2C(.dbd.O)--, alkoxyl, and lower alkylene.

21. The compound according to claim 20, wherein E is either ##STR00276##

22. The compound according to claim 21, wherein E is either ##STR00277##

23. The compound according to claim 22, wherein R.sup.2 and R.sup.3 are --H.

24. The compound according to claim 15, wherein A is --C(.dbd.NR.sup.6)--.

25. The compound according to claim 1, of formula II, ##STR00278## wherein E is selected from Table 7, TABLE-US-00015 TABLE 7 ##STR00279## ##STR00280## ##STR00281## ##STR00282## ##STR00283## ##STR00284##

wherein each R.sup.16 is independently selected from (1); --H, (2) lower alkyl; (3) --CO.sub.2R.sup.4, and (4) --C(.dbd.O)R.sup.4; or two of R.sup.16, together with the nitrogen or nitrogens to which they are attached, form a heterocyclic ring; each R.sup.17 is independently selected from (1) --H; (2) halogen; (3) oxo; (4) --CN; (5) --NH.sub.2; (6) --CF.sub.3; (7) --NO.sub.2; (8) --OR.sup.4; (9) --N(R.sup.4)R.sup.5; (10) --S(O).sub.0-2R.sup.5; (11) --SO.sub.2N(R.sup.4)R.sup.5; (12)--CO.sub.2R.sup.4; (13) --C(O)N(R.sup.4)R.sup.5; (14) --N(R.sup.4)SO.sub.2R.sup.5; (15) --N(R.sup.4)C(O)R.sup.5; (16) --N(R.sup.4)CO.sub.2R.sup.5; (17) --C(O)R.sup.4; (18) lower alkyl; (19) aryl; (20) arylalkyl; (21) heterocyclyl; and (22) lower heterocyclylalkyl; X is selected from --C(.dbd.O)N(H)(CH.sub.2).sub.1-2--, --(CH.sub.2).sub.1-2C(.dbd.O)N(H)--, --C(.dbd.O)N(H)--, --SO.sub.2N(H)(CH.sub.2).sub.1-2--, --(CH.sub.2).sub.1-2SO.sub.2N(H)--, --SO.sub.2N(H)--, --N(H)C(.dbd.O)N(H)(CH.sub.2).sub.1-2--, --N(H)C(.dbd.O)N(H)--, --(CH.sub.2).sub.0-2N(R.sup.4)(CH.sub.2).sub.0-2--, --(CH.sub.2).sub.0-2O(CH.sub.2).sub.0-2, --C(.dbd.O)N(H)N(H)--, --N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)----OCH.sub.2C(.dbd.O)N(H)CH.sub.- 2--, --(CH.sub.2).sub.1-2N(H)C(.dbd.O)N(H)--, --OCH.sub.2CH.sub.2O, --N(R.sup.4)CH.sub.2C(.dbd.O)N(H)CH.sub.2--, --(CH.sub.2).sub.0-1C(.dbd.O)N(H)(CH.sub.2).sub.1-2C(.dbd.O)--, alkoxyl, and lower alkylene; each R.sup.22 is independently selected from (1) --H; (2) halogen; (3) oxo; (4) --CN; (5) --NH.sub.2; (6) --CF.sub.3; (7) --NO.sub.2; (8) --OR.sup.4; (9) --N(R.sup.4)R.sup.5; (10) --S(O).sub.0-2R.sup.5; (11) --SO.sub.2N(R.sup.4)R.sup.5; (12) --CO.sub.2R.sup.4; (13) --C(O)N(R.sup.4)R.sup.5; (14) --N(R.sup.4)SO.sub.2R.sup.5; (15) --N(R.sup.4)C(O)R.sup.5; (16) --N(R.sup.4)CO.sub.2R.sup.5; (17) --C(O)R.sup.4; (18) lower alkyl; (19) aryl; (20) lower arylalkyl; (21) heterocyclyl; and (22) lower heterocyclylalkyl; Y is selected from Table 8, TABLE-US-00016 TABLE 8 ##STR00285## ##STR00286## ##STR00287## ##STR00288## ##STR00289## ##STR00290## ##STR00291## ##STR00292## ##STR00293## ##STR00294## ##STR00295## ##STR00296## ##STR00297## ##STR00298## ##STR00299## ##STR00300## ##STR00301## ##STR00302## ##STR00303## ##STR00304## ##STR00305## ##STR00306##

wherein each R.sup.15 is independently selected from (1) --H; (2) halogen; (3) oxo; (4) --CN; (5) --NH.sub.2; (6) --CF.sub.3; (7) --NO.sub.2; (8) --OR.sup.4; (9) --N(R.sup.4)R.sup.5; (10) --S(O).sub.0-2R.sup.5; (11) --SO.sub.2N(R.sup.4)R.sup.5; (12) --CO.sub.2R.sup.4; (13) --C(O)N(R.sup.4)R.sup.5; (14) --N(R.sup.4)SO.sub.2R.sup.5; (15) --N(R.sup.4)C(O)R.sup.5; (16) --N(R.sup.4)CO.sub.2R.sup.5; (17) --C(O)R.sup.4; (18) lower alkyl; (19) aryl; (20) lower arylalkyl; (21) heterocyclylalkyl and (22) heterocyclylalkyl.

26. The compound according to claim 1, of formula III, ##STR00307## wherein, each G is independently .dbd.N--or .dbd.C(R.sup.11)--; L is selected from --O--, --S(O).sub.0-2--, and --NR.sup.11; each R.sup.11 is independently selected from (1) --H; (2) halogen; (3) --CN; (4) --NH.sub.2; (5) --CF.sub.3; (6) --NO.sub.2; (7) --OR.sup.4; (8) --N(R.sup.4)R.sup.5; (9) --S(O).sub.0-2R.sup.5; (10) --SO.sub.2N(R.sup.4)R.sup.5; (11) --CO.sub.2R.sup.4; (12) --C(O)N(R.sup.4)R.sup.5; (13) --N(R.sup.4)SO.sub.2R.sup.5; (14) --N(R.sup.4)C(O)R.sup.5; (15) --N(R.sup.4)CO.sub.2R.sup.5; (16) --C(O)R.sup.4; (17) lower alkyl; X is selected from (1) --C(.dbd.O)N(H)(CH.sub.2).sub.1-2--; (2) --(CH.sub.2).sub.1-2C(.dbd.O)N(H)--; (3) --C(.dbd.O)N(H)--; (4) --SO.sub.2N(H)(CH.sub.2).sub.1-2--; (5) --(CH.sub.2).sub.1-2SO.sub.2N(H)--; (6) --SO.sub.2N(H)--; (7) --N(H)C(.dbd.O)N(H)(CH.sub.2).sub.1-2--; (8) --N(H)C(.dbd.O)N(H)--; (9) --(CH.sub.2).sub.0-2N(R.sup.4)(CH.sub.2).sub.0-2--; (10) --(CH.sub.2).sub.0-2O(CH.sub.2).sub.0-2; (11) --C(.dbd.O)N(H)N(H)--; (12) --N(R.sup.4)(CH.sub.2).sub.2-3N(R.sup.4)--; (13) --OCH.sub.2C(.dbd.O)N(H)CH.sub.2--; (14) --(CH.sub.2).sub.1-2N(H)C(.dbd.O)N(H)--; (15) --OCH.sub.2CH.sub.2O--; --N(R.sup.4)CH.sub.2C(.dbd.O)N(H)CH.sub.2--; (16) --(CH.sub.2).sub.0-1 C(.dbd.O)N(H)(CH.sub.2).sub.1-2C(O)--; (17) alkoxyl and (18) lower alkylene; Y is selected from Table 9, TABLE-US-00017 TABLE 9 ##STR00308## ##STR00309## ##STR00310## ##STR00311## ##STR00312## ##STR00313## ##STR00314## ##STR00315## ##STR00316## ##STR00317## ##STR00318## ##STR00319## ##STR00320## ##STR00321## ##STR00322## ##STR00323## ##STR00324## ##STR00325## ##STR00326## ##STR00327## ##STR00328## ##STR00329##

wherein each R.sup.15 is independently selected from (1) --H; (2) halogen; (3) oxo; (4) --CN; (5) --NH.sub.2; (6) --CF.sub.3; (7) --NO.sub.2; (8) --OR.sup.4; (9) --N(R.sup.4)R.sup.5; (10) --S(O).sub.0-2R.sup.5; (11) --SO.sub.2N(R.sup.4)R.sup.5; (12) --CO.sub.2R.sup.4; (13) --C(O)N(R.sup.4)R.sup.5; (14) --N(R.sup.4)SO.sub.2R.sup.5; (15) --N(R.sup.4)C(O)R.sup.5; (16) --N(R.sup.4)CO.sub.2R.sup.5; (17) --C(O)R.sup.4; (18) lower alkyl; (19) aryl; (20) lower arylalkyl; (21) heterocyclyl; and (22) lower heterocyclylalkyl; and each R.sup.22 is independently selected from (1) --H; (2) halogen; (3) oxo; (4) --CN; (5) --NH.sub.2; (6) --CF.sub.3; (7) --NO.sub.2; (8) --OR.sup.4; (9) --N(R.sup.4)R.sup.5; (10) --S(O).sub.0-2R.sup.5; (11) --SO.sub.2N(R.sup.4)R.sup.5; (12) --CO.sub.2R.sup.4; (13) --C(O)N(R.sup.4)R.sup.5; (14) --N(R.sup.4)SO.sub.2R.sup.5; (15) --N(R.sup.4)C(O)R.sup.5; (16) --N(R.sup.4)CO.sub.2R.sup.5; (17) --C(O)R.sup.4; (18) lower alkyl; (19) aryl; (20) lower arylalkyl; (21) heterocyclyl; and (22) lower heterocyclylalkyl.

27. A compound selected from Table 10, or a pharmaceutically acceptable salt thereof: TABLE-US-00018 TABLE 10 Name 3-amino-N,N-dimethyl-6-phenylpyrazine-2-carboxamide 3-amino-6-[3-(methyloxy)phenyl]pyrazine-2-carboxamide 3-amino-6-(4-fluorophenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-[4-(ethyloxy)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-(ethyloxy)phenyl]pyrazine-2-carboxamide 3-amino-6-{3-[(trifluoromethyl)oxy]phenyl}pyrazine-2-carboxamide 3-amino-6-[3-(aminocarbonyl)phenyl]pyrazine-2-carboxamide 6-[3-(acetylamino)phenyl]-3-aminopyrazine-2-carboxamide 3-amino-6-[4-(dimethylamino)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-methylphenyl)pyrazine-2-carboxamide methyl 3-[5-amino-6-(aminocarbonyl)pyrazin-2-yl]benzoate 3-amino-6-{3-[(phenylmethyl)oxy]phenyl}pyrazine-2-carboxamide 3-amino-6-biphenyl-3-ylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(phenylmethyl)oxy]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-hydroxyphenyl)-N-methylpyrazine-2-carboxamide 3-amino-N-[2-(methyloxy)ethyl]-6-phenylpyrazine-2-carboxamide N-[2-(acetylamino)ethyl]-3-amino-6-phenylpyrazine-2-carboxamide 3-amino-6-phenylpyrazine-2-carbohydrazide 3-amino-N-hydroxy-6-phenylpyrazine-2-carboxamide 3-amino-6-[3-(ethyloxy)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-(3-aminophenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-[4-(ethyloxy)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-methylphenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-[4-(methyloxy)phenyl]pyrazine-2-carboxamide 3-amino-6-biphenyl-3-yl-N-methylpyrazine-2-carboxamide 6-[3-(acetylamino)phenyl]-3-amino-N-methylpyrazine-2-carboxamide 3-amino-6-[3-(hydroxymethyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-[4-(hydroxymethyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(1E)-N-methylethanimidoyl]phenyl}pyrazine-2- carboxamide 3-amino-N-methyl-6-[3-(methyloxy)phenyl]pyrazine-2-carboxamide 3-amino-6-(4-fluoro-3-methylphenyl)-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-pyridin-3-ylpyrazine-2-carboxamide 6-[4-(acetylamino)phenyl]-3-amino-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(methylamino)carbonyl]phenyl}pyrazine-2-carboxamid- e 6-(3-acetylphenyl)-3-amino-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(5-methyl-1,2,4-oxadiazol-3-yl)pyrazine-2-carboxamide 3-amino-6-[4-(dimethylamino)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{4-[(methylsulfonyl)amino]phenyl}pyrazine-2-carboxamid- e 3-amino-6-(3,5-dimethylphenyl)-N-methylpyrazine-2-carboxamide 6-(4-acetylphenyl)-3-amino-N-methylpyrazine-2-carboxamide 3-amino-6-[3,4-bis(methyloxy)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(phenylcarbonyl)amino]phenyl}pyrazine-2-carboxamid- e 3-amino-N-methyl-6-{3-[(methylsulfonyl)amino]phenyl}pyrazine-2-carboxamid- e 3-amino-N-methyl-6-[3-(1H-tetrazol-5-yl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-[3-(aminocarbonyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-{3-[(dimethylamino)carbonyl]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-N-methyl-6-[4-(methylsulfonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-aminophenyl)-N-ethylpyrazine-2-carboxamide 3-amino-6-[3-({[(4-fluorophenyl)amino]carbonyl}amino)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4- (methyloxy)phenyl]amino}carbonyl)amino]phenyl}pyrazine-2-carboxamide 6,6'-[(oxomethanediyl)bis(iminobenzene-3,1-diyl)]bis(3-amino-N- methylpyrazine-2-carboxamide) 3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}benzoic acid 3-amino-N-methyl-6-{3-[(4-methylpiperazin-1-yl)carbonyl]phenyl}pyrazine-2- - carboxamide 3-amino-N-methyl-6-(3-{[(2-phenylethyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-N-methyl-6-{3-[({[4- (methyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(1R)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(4-chlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[methyl(phenylmethyl)amino]carbonyl}phenyl)pyrazin- e- 2-carboxamide 3-amino-6-[3-({[(2,4-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(4- methylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxami- de 3-amino-6-[3-({[(4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[(2,3-dihydro-1H-inden-2-ylamino)carbonyl]phenyl}-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[3-(methyloxy)phenyl]carbonyl}amino)phenyl]pyrazi- ne- 2-carboxamide 3-amino-N-methyl-6-[3-({[4-(methyloxy)phenyl]carbonyl}amino)phenyl]pyrazi- ne- 2-carboxamide 3-amino-N-methyl-6-{3-[({[3- (methyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({(1R)-1-[4- (methyloxy)phenyl]ethyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[2- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxami- de 3-amino-6-[3-({[(3-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4-chlorophenyl)carbonyl]amino}phenyl)-N-methylpyrazine-2-- carboxamide 3-amino-6-[3-({[1-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[2,3-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - methylpyrazine-2-carboxamide 3-amino-6-(3-{[bis(phenylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-2- - carboxamide 3-amino-6-{3-[({[2,4-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - methylpyrazine-2-carboxamide 3-amino-6-(3-{[ethyl(pyridin-4-ylmethyl)amino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[4-(phenylmethyl)piperazin-1- yl]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[1-(phenylmethyl)piperidin-4- yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(4-methylphenyl)carbonyl]amino}phenyl)pyrazine-2-- carboxamide 3-amino-N-methyl-6-[3-({[(5-methylpyrazin-2- yl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(pyridin-2-ylmethyl)amino]carbonyl}phenyl)pyrazin- e-2- carboxamide 3-amino-N-methyl-6-(3-{[(pyridin-3-ylmethyl)amino]carbonyl}phenyl)pyrazin- e-2- carboxamide 3-amino-N-methyl-6-(3-{[(pyridin-4-ylmethyl)amino]carbonyl}phenyl)pyrazin- e-2- carboxamide 3-amino-6-{3-[(furan-2-ylcarbonyl)amino]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-6-[3-({[(3-chlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(cyclohexylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-- 2- carboxamide 3-amino-N-methyl-6-(3-{[(2-phenylpropyl)amino]carbonyl}phenyl)pyrazine-2-- carboxamide 3-amino-6-[3-({[(2-chlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[2-(2-chlorophenyl)ethyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({2-[2- (methyloxy)phenyl]ethyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-[3-({[2-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[2-(2-thienyl)ethyl]amino}carbonyl)phenyl]pyrazin- e-2- carboxamide 3-amino-6-{3-[(cyclohexylamino)carbonyl]phenyl}-N-methylpyrazine-2- carboxamide 1,1-dimethylethyl 4-({[(3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)carbonyl]amino}methyl)piperidine-1-carboxylate 3-amino-N-methyl-6-(3-{[(piperidin-4-ylmethyl)amino]carbonyl}phenyl)pyraz- ine- 2-carboxamide 3-amino-N-methyl-6-[3-(5-phenyl-1,2,4-oxadiazol-3-yl)phenyl]pyrazine-2- carboxamide 3-amino-N-methyl-6-{3-[5-(phenylmethyl)-1,2,4-oxadiazol-3-yl]phenyl}pyraz- ine- 2-carboxamide 3-amino-N-methyl-6-{3-[5-(2-phenylethyl)-1,2,4-oxadiazol-3-yl]phenyl}pyra- zine- 2-carboxamide 3-amino-6-(3-{[(1,1-dimethylethyl)amino]carbonyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(phenylamino)carbonyl]phenyl}pyrazine-2-carboxamid- e 3-amino-6-[3-(1,3-dihydro-2H-isoindol-2-ylcarbonyl)phenyl]-N-methylpyrazi- ne-2- carboxamide 3-amino-N-methyl-6-[3-({[(1R)-1-phenylethyl]amino}carbonyl)phenyl]pyrazin- e-2- carboxamide 3-amino-N-methyl-6-[3-({[(1S)-1-phenylethyl]amino}carbonyl)phenyl]pyrazin- e-2- carboxamide 3-amino-N-methyl-6-[3-({[(1R)-1-phenylpropyl]amino}carbonyl)phenyl]pyrazi- ne- 2-carboxamide 3-amino-N-methyl-6-[3-({[(1S)-1-phenylpropyl]amino}carbonyl)phenyl]pyrazi- ne- 2-carboxamide 3-amino-N-methyl-6-[3-({[(1R,2S)-2- phenylcyclopropyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide phenylmethyl 4-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}benzoate 3-amino-N-methyl-6-(4-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-N-methyl-6-(4-{[(2-phenylethyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-[4-({[(2,4-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[4-({[(4- methylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(4-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4-chlorophenyl)acetyl]amino}phenyl)-N-methylpyrazine-2- carboxamide 3-amino-N-methyl-6-[3-({[3-(phenyloxy)phenyl]carbonyl}amino)phenyl]pyrazi- ne- 2-carboxamide 3-amino-6-{3-[(diphenylacetyl)amino]phenyl}-N-methylpyrazine-2-carboxamid- e 3-amino-N-methyl-6-{3-[(phenylacetyl)amino]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(3-phenylpropanoyl)amino]phenyl}pyrazine-2- carboxamide 3-amino-N-methyl-6-(3-{[(1R)-1,2,3,4-tetrahydronaphthalen-1- ylamino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1- ylamino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[3,4,5- tris(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide- 3-amino-N-methyl-6-{3-[({(1R,2R)-2- [(phenylmethyl)oxy]cyclopentyl}amino)carbonyl]phenyl}pyrazine-2-carboxami- de 3-amino-N-methyl-6-{3-[({(1S,2S)-2- [(phenylmethyl)oxy]cyclopentyl}amino)carbonyl]phenyl}pyrazine-2-carboxami- de 3-amino-6-(3-cyanophenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-{3-[(cyclopentylcarbonyl)amino]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-6-(3-{[(4-cyanophenyl)carbonyl]amino}phenyl)-N-methylpyrazine-2- carboxamide 3-amino-N-methyl-6-[3- ({[(phenylmethyl)amino]carbonyl}amino)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(naphthalen-2- ylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(tetrahydrofuran-2-

ylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-[3-({[(2-chloro-6-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[3-fluoro-5- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-methylpyrazine-2-- carboxamide 3-amino-6-{3-[({2-[3,5-bis(methyloxy)phenyl]ethyl}amino)carbonyl]phenyl}-- N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(2-phenylethyl)oxy]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[2-(4-methylpiperidin-1-yl)ethyl]oxy}phenyl)pyrazi- ne-2- carboxamide 3-amino-6-[3-({2-[4-(2-hydroxyethyl)piperidin-1-yl]ethyl}oxy)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[2-(3-hydroxypyrrolidin-1-yl)ethyl]oxy}phenyl)-N-methylpyra- zine- 2-carboxamide 3-amino-6-[3-({2-[ethyl(phenylmethyl)amino]ethyl}oxy)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[2-(diethylamino)ethyl]oxy}phenyl)-N-methylpyrazine-2- carboxamide 3-amino-6-(3-{[(biphenyl-2-ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazi- ne- 2-carboxamide 3-amino-N-methyl-6-(3-{[2-(4-phenylpiperazin-1-yl)ethyl]oxy}phenyl)pyrazi- ne-2- carboxamide 3-amino-6-(3-{[(biphenyl-4-ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazi- ne- 2-carboxamide 3-amino-N-methyl-6-[3-({2- [methyl(phenylmethyl)amino]ethyl}oxy)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4- (phenyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(2-morpholin-4-ylethyl)oxy]phenyl}pyrazine-2- carboxamide 3-amino-6-[3-({2-[(cyclopropylmethyl)(propyl)amino]ethyl}oxy)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({2-[4-(phenylmethyl)piperidin-1- yl]ethyl}oxy)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(2-piperidin-1-ylethyl)oxy]phenyl}pyrazine-2- carboxamide 3-amino-N-methyl-6-{3-[({[3- (phenyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[2-(4-ethylpiperazin-1-yl)ethyl]oxy}phenyl)-N-methylpyrazin- e-2- carboxamide 3-amino-N-methyl-6-{3-[(2-pyrrolidin-1-ylethyl)oxy]phenyl}pyrazine-2- carboxamide 3-amino-N-methyl-6-(3-{[2-(4-methylpiperazin-1-yl)ethyl]oxy}phenyl)pyrazi- ne-2- carboxamide 3-amino-6-[3-({2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}oxy)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[2-(3,4-dihydroisoquinolin-2(1H)-yl)ethyl]oxy}phenyl)-N- methylpyrazine-2-carboxamide ethyl 4-{2-[(3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)oxy]ethyl}piperazine-1-carboxylate 3-amino-N-methyl-6-[3-({[(3S)-1-(phenylmethyl)pyrrolidin-3- yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(3R)-1-(phenylmethyl)pyrrolidin-3- yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[2-(phenyloxy)ethyl]amino}carbonyl)phenyl]pyrazin- e-2- carboxamide 3-amino-N-methyl-6-{3-[({2-[4-(phenylmethyl)piperazin-1- yl]ethyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[1-(phenylmethyl)piperidin-4- yl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(furan-3-ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-- 2- carboxamide 3-amino-6-(3-{[(2,3-dihydro-1,4-benzodioxin-2- ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(furan-2-ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-- 2- carboxamide 3-amino-N-methyl-6-{3-[({[4-(phenylmethyl)morpholin-2- yl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(2,3-dihydro-1,4-benzodioxin-6- ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(2,3-dihydro-1,4-benzodioxin-6- ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(2,3-dihydro-1-benzofuran-5-ylmethyl)amino]carbonyl}phenyl- )-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(6-fluoro-4H-1,3-benzodioxin-8- yl)methyl]amino}carbonyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(2,4-dichlorophenyl)acetyl]amino}phenyl)-N-methylpyrazine-- 2- carboxamide 3-amino-6-(3-{[(3,4-dichlorophenyl)acetyl]amino}phenyl)-N-methylpyrazine-- 2- carboxamide 3-amino-N-methyl-6-[3-({[4- (trifluoromethyl)phenyl]acetyl}amino)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3,5-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(5-chloro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-difluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4- (methylthio)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(2-methylpropyl)amino]carbonyl}phenyl)pyrazine-2-- carboxamide 3-amino-N-methyl-6-(3-{[({3- [(trifluoromethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-(3-{[(cyclopropylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-6-{3-[(cyclopentylamino)carbonyl]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-N-methyl-6-(3-{[(4-methylphenyl)amino]carbonyl}phenyl)pyrazine-2-- carboxamide 3-amino-N-methyl-6-[3-({[4-(methyloxy)phenyl]amino}carbonyl)phenyl]pyrazi- ne- 2-carboxamide 3-amino-6-(3-{[(1,3-benzodioxol-5-ylmethyl)amino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(biphenyl-3-ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazi- ne- 2-carboxamide 3-amino-N-methyl-6-(3-{[(1-methyl-1- phenylethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-difluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[({4- [(trifluoromethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-{3-[({[4-fluoro-3- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-methylpyrazine-2-- carboxamide 3-amino-6-{3-[({[4-chloro-3- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-methylpyrazine-2-- carboxamide 3-amino-6-[3-({[(4-aminophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-aminophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-aminophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-pyrimidin-5-ylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-(methylsulfonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]pyrazine-2- carboxamide 3-amino-6-(4-hydroxyphenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-{3-[({[4-(aminosulfonyl)phenyl]methyl}amino)carbonyl]phenyl}-N-- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[4-(dimethylamino)phenyl]methyl}amino)carbonyl]phenyl}-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-bromophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(4-chloro-3-{[(phenylmethyl)amino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide methyl 3-{5-amino-6-[(cyclopropylamino)carbonyl]pyrazin-2-yl}benzoate methyl 3-{5-amino-6-[(ethylamino)carbonyl]pyrazin-2-yl}benzoate 3-amino-6-[3-({[(2,3-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[4-hydroxy-3-(methyloxy)phenyl]methyl}amino)carbonyl]phen- yl}- N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[(4-chloro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[2-(ethyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[2-chloro-6-(phenyloxy)phenyl]methyl}amino)carbonyl]pheny- l}- N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,5-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[2,6-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-chloro-6-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2,4,5- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2,2-dimethylpropyl)amino]carbonyl}phenyl)-N-methylpyrazin- e-2- carboxamide 3-amino-6-(3-{[(cyclopentylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-6-{3-[({[3,5-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4- (methylsulfonyl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamid- e 3-amino-6-[3-({[(5-bromo-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-bromo-4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[2,4,6- tris(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide- 3-amino-N-methyl-6-[3-({[(3- methylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-bromo-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,5-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[3,5-bis(trifluoromethyl)phenyl]methyl}amino)carbonyl]phe- nyl}- N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(2,2-diphenylethyl)amino]carbonyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-N-methyl-6-(3-thienyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(phenylmethyl)amino]sulfonyl}phenyl)pyrazine-2- carboxamide 5,5'-diamino-N,N'-dimethyl-2,2'-bipyrazine-6,6'-dicarboxamide 3-amino-6-(1H-indol-5-yl)-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(2-thienyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-pyridin-4-ylpyrazine-2-carboxamide 3-amino-N-cyclopropyl-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazine- -2- carboxamide 3-amino-6-[3-({[(2-chloro-6-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- cyclopropylpyrazine-2-carboxamide 3-amino-N-ethyl-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-[3-({[(2-chloro-6-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- ethylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(4-chloro-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3,5-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(5-chloro-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N--

methylpyrazine-2-carboxamide 3-amino-6-{3-[(cyclopropylamino)carbonyl]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-6-[3-({[(3,4-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(4'-fluorobiphenyl-2-yl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2,3,4- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-2,6-difluorophenyl)methyl]amino}carbonyl)phenyl- ]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-2,6-difluorophenyl)methyl]amino}carbonyl)phenyl- ]-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[(9H-fluoren-9-ylamino)carbonyl]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-N-methyl-6-[3-({[(2- methylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3,4-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(5-fluoro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3,4-difluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4-(4-methylpiperazin-1- yl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(4-fluoro-3-{[(phenylmethyl)amino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2,4,6- trichlorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[2,5-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-fluoro-4-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-chloro-6-fluoro-3- methylphenyl)methyl]amino}carbonyl)phenyl]-N-methylpyrazine-2-carboxamide- 3-amino-6-[3-({[(2-chloro-3,6-difluorophenyl)methyl]amino}carbonyl)phenyl- ]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-difluoro-4-methylphenyl)methyl]amino}carbonyl)phenyl- ]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(4-fluoro-3-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(6-chloro-2-fluoro-3- methylphenyl)methyl]amino}carbonyl)phenyl]-N-methylpyrazine-2-carboxamide- 3-amino-6-[3-({[(4-iodophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-4-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(4-bromophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-bromophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2,3,6- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2,3,6- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(phenylcarbonyl)amino]methyl}phenyl)pyrazine-2- carboxamide 3-amino-6-[3-({[(4-chlorophenyl)carbonyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,5-difluorophenyl)carbonyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(naphthalen-2- ylcarbonyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(phenylmethyl)thio]methyl}phenyl)pyrazine-2- carboxamide 3-amino-N-methyl-6-(3-{[(phenylmethyl)sulfonyl]methyl}phenyl)pyrazine-2- carboxamide 3-amino-N-methyl-6-(3-{[(phenylmethyl)oxy]methyl}phenyl)pyrazine-2- carboxamide 3-amino-N-methyl-6-(3-{[(phenylmethyl)amino]methyl}phenyl)pyrazine-2- carboxamide 3-amino-N-methyl-6-[3-({[(3,4,5- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 9H-fluoren-9-ylmethyl (3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)carbamate phenylmethyl (3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)carbamate ethyl (3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}phenyl)carbamate 3-amino-6-[3-({[(3,4-dichlorophenyl)carbonyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 1,1-dimethylethyl (3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)carbamate (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl (3-{5-amino-6- [(methylamino)carbonyl]pyrazin-2-yl}phenyl)carbamate 3-amino-6-[3-({[(4-hydroxyphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[({4-[(2-morpholin-4- ylethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[2- (methyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-[3-({[(3-hydroxyphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-hydroxyphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(2-phenylhydrazino)carbonyl]phenyl}pyrazine-2- carboxamide 3-amino-N-(2-hydroxyethyl)-6-(3-methylphenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(phenylacetyl)amino]methyl}phenyl)pyrazine-2- carboxamide 3-amino-6-[3-({[(4-chlorophenyl)acetyl]amino}methyl)phenyl]-N-methylpyraz- ine- 2-carboxamide 3-amino-6-(3-{[(biphenyl-4-ylcarbonyl)amino]methyl}phenyl)-N-methylpyrazi- ne- 2-carboxamide 3-amino-6-{3-[({[2-chloro-5- (trifluoromethyl)phenyl]carbonyl}amino)methyl]phenyl}-N-methylpyrazine-2-- carboxamide N-[(3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}phenyl)methyl]-1H- indole-2-carboxamide 3-amino-6-[3-({[(3-hydroxypyridin-2-yl)carbonyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(1H-indol-3-ylacetyl)amino]methyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-6-[3-({[(2,5-difluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,6-difluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3,5-difluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3-iodophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2-morpholin-4- ylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[({3-[(2-morpholin-4- ylethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(4-morpholin-4- ylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(3-morpholin-4- ylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4-(1- methylethyl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[({[4-(1- methylethyl)phenyl]oxy}acetyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-{3-[({[(4-aminophenyl)thio]acetyl}amino)methyl]phenyl}-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(4-(methyloxy)-3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(5-{[(phenylmethyl)amino]carbonyl}pyridin-3-yl)pyrazin- e-2- carboxamide 3-amino-6-[3-({[(4-iodophenyl)carbonyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(4- pentylphenyl)carbonyl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1,3-benzodioxol-5-ylcarbonyl)amino]methyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[4-(1,1-dimethylethyl)phenyl]methyl}amino)carbonyl]phenyl- }-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[({1-[5-(trifluoromethyl)pyrimidin-2-yl]piperidin-- 4- yl}carbonyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2-piperidin-1- ylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[2- (methylthio)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 1,1-dimethylethyl (3R)-3-{[(3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)carbonyl]amino}pyrrolidine-1-carboxylate 3-amino-N-methyl-6-(3-{[(3R)-pyrrolidin-3-ylamino]carbonyl}phenyl)pyrazin- e-2- carboxamide 3-{[(4-chlorophenyl)methyl]amino}-6-{3-[({(3R)-1-[(4- chlorophenyl)methyl]pyrrolidin-3-yl}amino)carbonyl]phenyl}-N-methylpyrazi- ne-2- carboxamide 3-amino-6-{3-[({(3R)-1-[(2,4-dichlorophenyl)methyl]pyrrolidin-3- yl}amino)carbonyl]phenyl}-N-methylpyrazine-2-carboxamide N-methyl-3-({[3-(methyloxy)phenyl]methyl}amino)-6-(3-{[((3R)-1-{[3- (methyloxy)phenyl]methyl}pyrrolidin-3-yl)amino]carbonyl}phenyl)pyrazine-2- - carboxamide 3-amino-6-{3-[({(3R)-1-[(2,6-dichlorophenyl)methyl]pyrrolidin-3- yl}amino)carbonyl]phenyl}-N-methylpyrazine-2-carboxamide N-methyl-3-[(phenylmethyl)amino]-6-[3-({[(3R)-1-(phenylmethyl)pyrrolidin-- 3- yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 1,1-dimethylethyl 3-({[(3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)carbonyl]amino}methyl)pyrrolidine-1-carboxylate 1,1-dimethylethyl 2-({[(3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)carbonyl]amino}methyl)pyrrolidine-1-carboxylate 3-amino-N-methyl-6-(3-{[(pyrrolidin-3-ylmethyl)amino]carbonyl}phenyl)pyra- zine- 2-carboxamide 3-amino-N-methyl-6-(3-{[(pyrrolidin-2-ylmethyl)amino]carbonyl}phenyl)pyra- zine- 2-carboxamide 3-amino-6-(2-fluoro-5-{[(phenylmethyl)amino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[(1,3-benzodioxol-5-ylacetyl)amino]phenyl}-N-methylpyrazine-- 2- carboxamide 3-amino-6-[3-({[(2-chloro-4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[3,4-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(phenylmethyl)amino]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[({2-[(2-morpholin-4- ylethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4-(1- methylethyl)phenyl]carbonyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-6-[3-({[(4-butylphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4-(1,2,3-thiadiazol-4- yl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4-(2- thienyl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-{3-[({[4-(1,1-dimethylethyl)phenyl]carbonyl}amino)methyl]phenyl- }-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4-(1H-pyrazol-1- yl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(3,4-dihydro-2H-1,4-benzoxazin-6- ylmethyl)amino]carbonyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-amino-6-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(biphenyl-4-ylmethyl)amino]methyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-6-(3-{[(biphenyl-2-ylmethyl)amino]methyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-6-(3-{[(biphenyl-3-ylmethyl)amino]methyl}phenyl)-N-methylpyrazine- -2- carboxamide 3-amino-N-methyl-6-{3-[({[1-(phenylmethyl)pyrrolidin-2- yl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide

3-amino-6-(3-{[(3,4-dihydro-2H-1,4-benzoxazin-6- ylmethyl)amino]methyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-difluorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,5-difluorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-difluorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2-pyridin-4- ylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2-pyridin-3- ylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4- (methylsulfonyl)phenyl]methyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(2,2-diphenylethyl)amino]methyl}phenyl)-N-methylpyrazine-2- - carboxamide 3-amino-N-methyl-6-{3-[({[1-(phenylmethyl)pyrrolidin-3- yl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[3- (phenyloxy)phenyl]methyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-6-[3-({[(4-aminophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4- (phenyloxy)phenyl]methyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-6-{3-[({[2,6-bis(methyloxy)phenyl]methyl}amino)methyl]phenyl}-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-fluorophenyl)methyl]amino}methyl)phenyl]-N-methylpyraz- ine- 2-carboxamide 3-amino-6-[5-({[(2,6-difluorophenyl)methyl]amino}carbonyl)pyridin-3-yl]-N- - methylpyrazine-2-carboxamide 3-amino-6-(5-{[(biphenyl-2-ylmethyl)amino]carbonyl}pyridin-3-yl)-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2,6-difluorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino]methyl}pheny- l)- N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2-piperidin-1- ylphenyl)methyl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-fluoro-2- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-methylpyrazine-2-- carboxamide 3-amino-N-methyl-6-{3-[({[6-(trifluoromethyl)pyridin-3- yl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-[3-(1H-benzimidazol-2-yl)phenyl]-N-methylpyrazine-2-carboxamide- 3-amino-6-[3-({[(2,5-dichlorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(3,5-dichlorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(2-phenylethyl)amino]phenyl}pyrazine-2-carboxamide- 3-amino-6-(5-{[(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino]carbonyl}pyr- idin- 3-yl)-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[2- (phenylamino)ethyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-ethylphenyl)methyl]amino}carbonyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(4-pyridin-3- ylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-{3-[(2,3-dihydro-1H-inden-2-ylamino)methyl]phenyl}-N- methylpyrazine-2-carboxamide 3-amino-6-[3-(1,3-dihydro-2H-isoindol-2-ylmethyl)phenyl]-N-methylpyrazine- -2- carboxamide 3-amino-6-(3-{[(1R)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(3,4,5- trifluorophenyl)methyl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(1R)-1-phenylethyl]amino}methyl)phenyl]pyrazine-- 2- carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[4-(2- thienyl)phenyl]methyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[3-(1,2,3-thiadiazol-4- yl)phenyl]methyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(4- propylphenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-chloro-2-fluorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({[3- (trifluoromethyl)phenyl]methyl}amino)methyl]phenyl}pyrazine-2-carboxamide- 3-amino-N-methyl-6-[3-({[(1S)-1-phenylethyl]amino}methyl)phenyl]pyrazine-- 2- carboxamide 3-amino-6-[3-({[(1R)-2-hydroxy-1-phenylethyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide methyl (2S)-{[(3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2- yl}phenyl)methyl]amino}(phenyl)ethanoate 3-amino-6-(3-{[2-(2,5-difluorophenyl)hydrazino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[2-(2,3,5,6-tetrafluoro-4- methylphenyl)hydrazino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[2-(2-fluorophenyl)hydrazino]carbonyl}phenyl)-N-methylpyraz- ine- 2-carboxamide 3-amino-6-(3-{[2-(2,4-difluorophenyl)hydrazino]carbonyl}phenyl)-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[2-(2,3,5,6- tetrafluorophenyl)hydrazino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(5-methylpyrazin-2- yl)methyl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(1S)-1,2,3,4-tetrahydronaphthalen-1- ylamino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(3S)-1-(phenylmethyl)pyrrolidin-3- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(3R)-1-(phenylmethyl)pyrrolidin-3- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[ethyl(phenylmethyl)amino]methyl}phenyl)-N-methylpyrazine-2- - carboxamide 3-amino-N-methyl-6-[3-({[(1S,2S)-2- phenylcyclopropyl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-Amino-6-(3-benzylcarbamoyl-phenyl)-pyrazine-2-carboxylic acid methylamide 3-amino-N-methyl-6-[3-(4-phenyl-1H-imidazol-2-yl)phenyl]pyrazine-2- carboxamide 3-amino-N-methyl-6-[3-({[(4- propylphenyl)methyl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(5-bromo-2-fluorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(2R)-1,2,3,4-tetrahydronaphthalen-2- ylamino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(1-methyl-1- phenylethyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-{3-[(9H-fluoren-9-ylamino)methyl]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-N-methyl-6-{3-[(naphthalen-1-ylamino)methyl]phenyl}pyrazine-2- carboxamide 3-amino-6-[3-({[(3-fluorobiphenyl-4-yl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[2-fluoro-4-(2-thienyl)phenyl]methyl}amino)methyl]phenyl}- -N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2-fluoro-4-furan-2-ylphenyl)methyl]amino}methyl)phenyl]-- N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[(naphthalen-2-ylamino)methyl]phenyl}pyrazine-2- carboxamide 3-amino-6-[3-({[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(2S)-1,2,3,4-tetrahydronaphthalen-2- ylamino]methyl}phenyl)pyrazine-2-carboxamide methyl 3-amino-6-(3-{[(4,7-difluoro-2,3-dihydro-1H-inden-1- yl)amino]methyl}phenyl)pyrazine-2-carboxylate 3-amino-6-(3-{[(5-bromo-2,3-dihydro-1H-inden-2-yl)amino]methyl}phenyl)-N-- methylpyrazine-2-carboxamide 3-amino-6-{3-[({[2-fluoro-5-(2-thienyl)phenyl]methyl}amino)methyl]phenyl}- -N- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(4-ethenyl-2-fluorophenyl)methyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4,7-difluoro-3-methyl-2,3-dihydro-1H-inden-1- yl)amino]methyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(1S,2R)-2-(methyloxy)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(5-bromo-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N-- methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2S)-6-bromo-1,2,3,4-tetrahydronaphthalen-2- yl]amino}methyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2R)-6-bromo-1,2,3,4-tetrahydronaphthalen-2- yl]amino}methyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(5-fluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-6-[3-({[(2S)-5-bromo-2,3-dihydro-1H-inden-2-yl]amino}methyl)pheny- l]- N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4-fluoro-2,3-dihydro-1H-inden-2-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4-fluoro-1-hydroxy-2,3-dihydro-1H-inden-2- yl)amino]methyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(1R,2S)-2-(methyloxy)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(4,7-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(6-bromo-4-fluoro-2,3-dihydro-1H-inden-1- yl)amino]methyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(3-oxo-2,3-dihydro-1H-inden-1- yl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(5-furan-2-yl-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4-fluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4,6-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(6-fluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-6-(3-{[(5,6-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(5-chloro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[5-(2-thienyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(5,7-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(5-furan-3-yl-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[5-(3-thienyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1S)-4-fluoro-2,3-dihydro-1H-inden-1-yl]amino}methyl)phen- yl]- N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[(1S)-5,7-difluoro-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]-N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(7-bromo-4-fluoro-2,3-dihydro-1H-inden-1- yl)amino]methyl}phenyl)-N-methylpyrazine-2-carboxamide 3-amino-6-(3-{[(6-chloro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4,6-dichloro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(4-chloro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N- ethylpyrazine-2-carboxamide 3-amino-6-(3-{[(5,7-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- ethylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(1S)-5-(2-thienyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(5-phenyl-2,3-dihydro-1H-inden-1- yl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(4-bromo-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N-- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(4-phenyl-2,3-dihydro-1H-inden-1-

yl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[4-(2-thienyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[6-(2-thienyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[5-(4-methyl-2-thienyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[(2R)-6-phenyl-1,2,3,4-tetrahydronaphthalen-2- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-N-methyl-6-naphthalen-2-ylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({(1S,2S)-2- [(phenylmethyl)oxy]cyclopentyl}amino)methyl]phenyl}pyrazine-2-carboxamide- 3-amino-6-{3-[(cyclopentylamino)methyl]phenyl}-N-methylpyrazine-2- carboxamide 3-amino-6-(3-{[(6-bromo-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N-- methylpyrazine-2-carboxamide 3-amino-6-(3-{[(7-fluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-N-methyl-6-quinolin-3-ylpyrazine-2-carboxamide 3-amino-6-[3-(1H-imidazol-1-ylmethyl)phenyl]-N-methylpyrazine-2-carboxami- de 3-amino-N-methyl-6-{3-[({5-[(2-morpholin-4-ylethyl)oxy]-2,3-dihydro-1H-in- den-1- yl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({(1R,2R)-2- [(phenylmethyl)oxy]cyclopentyl}amino)methyl]phenyl}pyrazine-2-carboxamide- 3-amino-6-{3-[(2,3-dihydro-1-benzofuran-3-ylamino)methyl]phenyl}-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[({5-[(cyanomethyl)oxy]-2,3-dihydro-1H-inden-1- yl}amino)methyl]phenyl}-N-methylpyrazine-2-carboxamide 2-amino-5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N- methylpyridine-3-carboxamide 3-amino-N-methyl-6-[3-({[5-(4-methylphenyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[2-(dimethylamino)-1-phenylethyl]amino}methyl)phenyl]-N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-[3-({[5-(1H-1,2,4-triazol-1-yl)-2,3-dihydro-1H-inden-1- - yl]amino}methyl)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(5-hydroxy-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-- N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{3-[({4-[(2-morpholin-4-ylethyl)oxy]-2,3-dihydro-1H-in- den-1- yl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(4-hydroxy-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-- N- methylpyrazine-2-carboxamide 3-amino-N-methyl-6-{1-[(phenylmethyl)amino]isoquinolin-7-yl}pyrazine-2- carboxamide 3-amino-N-methyl-6-(3-{[(2-morpholin-4-yl-1- phenylethyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-methyl-6-(3-{[(1-phenyl-2-pyrrolidin-1- ylethyl)amino]methyl}phenyl)pyrazine-2-carboxamide 2-amino-5-(3-{[(6-bromo-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N-- methylpyridine-3-carboxamide 2-amino-5-(3-{[(4,6-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyridine-3-carboxamide 2-amino-5-(3-{[(7-bromo-4-fluoro-2,3-dihydro-1H-inden-1- yl)amino]methyl}phenyl)-N-methylpyridine-3-carboxamide 2-amino-5-(3-{[(4-chloro-2,3-dihydro-1H-inden-1-yl)amino]methyl}phenyl)-N- - methylpyridine-3-carboxamide 2-amino-5-(3-{[(5,6-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyridine-3-carboxamide 2-amino-5-(3-{[(5,7-difluoro-2,3-dihydro-1H-inden-1-yl)amino]methyl}pheny- l)-N- methylpyridine-3-carboxamide 3-amino-6-{1-[(1S)-2,3-dihydro-1H-inden-1-ylamino]isoquinolin-7-yl}-N- methylpyrazine-2-carboxamide 3-amino-6-{3-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-2,3-dihydro-1H-inden-5- -yl}- N-methylpyrazine-2-carboxamide 3-amino-6-[3-({[6-(3-hydroxypropyl)-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]-N-methylpyrazine-2-carboxamide 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(1,3-oxazol-5- - yl)pyrazin-2-amine 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)pyrazine- -2- carbohydrazide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)pyrazine- -2- carboxamide 1-[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)pyraz- in- 2-yl]ethanone 3-amino-6-{3-[(2,3-dihydro-1H-inden-1-ylamino)methyl]phenyl}-N-(naphthale- n- 2-ylmethyl)pyrazine-2-carboxamide 3-amino-N-cyclohexyl-6-{3-[(2,3-dihydro-1H-inden-1- ylamino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(pyri- din- 4-ylmethyl)pyrazine-2-carboxamide {3-[5-amino-6-(4H-1,2,4-triazol-3-yl)pyrazin-2-yl]phenyl}methanol 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(4H-1,2,4-tri- azol- 3-yl)pyrazin-2-amine 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(2,2,- 2- trifluoroethyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(5- hydroxypentyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(4- hydroxybutyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(2- pyrrolidin-1-ylethyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(2- piperidin-1-ylethyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(2- morpholin-4-ylethyl)pyrazine-2-carboxamide 3-amino-N-(cyclopropylmethyl)-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino}methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N- (phenylmethyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(2- phenylethyl)pyrazine-2-carboxamide [3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)pyrazin- -2- yl](phenyl)methanone 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(2- hydroxyethyl)pyrazine-2-carboxamide 3-amino-N-cyclopropyl-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]methyl}phenyl)pyrazine-2-carboxamide 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(pyrrolidin-1- - ylcarbonyl)pyrazin-2-amine {3-[5-amino-6-(5-methyl-4H-1,2,4-triazol-3-yl)pyrazin-2-yl]phenyl}methano- l {3-[5-amino-6-(5-phenyl-4H-1,2,4-triazol-3-yl)pyrazin-2-yl]phenyl}methano- l (3-{5-amino-6-[5-(phenylmethyl)-4H-1,2,4-triazol-3-yl]pyrazin-2- yl}phenyl)methanol 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N'- methylpyrazine-2-carbohydrazide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N,N- dimethylpyrazine-2-carboxamide 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-[5-(phenylmet- hyl)- 4H-1,2,4-triazol-3-yl]pyrazin-2-amine 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-[2- (dimethylamino)ethyl]pyrazine-2-carboxamide 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(3-phenyl-1H-- 1,2,4-triazol-5-yl)pyrazin-2-amine 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-[2-(1- H- imidazol-4-yl)ethyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-[2- (methylamino)ethyl]pyrazine-2-carboxamide 3-{5-amino-6-[(3-fluorophenyl)carbonyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(3- hydroxypropyl)pyrazine-2-carboxamide 1,1-dimethylethyl 4-({[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)piperid- ine- 1-carboxylate 1,1-dimethylethyl 4-[({[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}amino)methyl]piperidine-1-carboxylate 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-piperidin-4-ylpyraz- ine- 2-carboxamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-(piperidin-4- ylmethyl)pyrazine-2-carboxamide 3-[5-amino-6-(morpholin-4-ylcarbonyl)pyrazin-2-yl]-N-(phenylmethyl)benzam- ide 1,1-dimethylethyl 3-({[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrroli- dine- 1-carboxylate 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-pyrrolidin-3-ylpyra- zine- 2-carboxamide (3-{5-amino-6-[5-(1,1-dimethylethyl)-4H-1,2,4-triazol-3-yl]pyrazin-2- yl}phenyl)methanol {3-[5-amino-6-(5-furan-2-yl-4H-1,2,4-triazol-3-yl)pyrazin-2-yl]phenyl}met- hanol [3-(5-amino-6-{5-[3-(methyloxy)phenyl]-4H-1,2,4-triazol-3-yl}pyrazin-2- yl)phenyl]methanol 2-({3-amino-6-[3-(hydroxymethyl)phenyl]pyrazin-2-yl}carbonyl)-N- phenylhydrazinecarboxamide 3-{5-amino-6-[(4-methylpiperazin-1-yl)carbonyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-(5-amino-6-{[4-(4-fluorophenyl)piperazin-1-yl]carbonyl}pyrazin-2-yl)-N-- (phenylmethyl)benzamide 3-(5-amino-6-{[4-(phenylmethyl)piperazin-1-yl]carbonyl}pyrazin-2-yl)-N- (phenylmethyl)benzamide methyl N-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}glycinate N-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}glycine 3-{5-amino-6-[(3,5-difluorophenyl)carbonyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-[5-amino-6-(biphenyl-4-ylcarbonyl)pyrazin-2-yl]-N-(phenylmethyl)benzami- de {3-[5-amino-6-(3-pyridin-3-yl-1H-1,2,4-triazol-5-yl)pyrazin-2-yl]phenyl}m- ethanol (3-{5-amino-6-[3-(4-chlorophenyl)-1H-1,2,4-triazol-5-yl]pyrazin-2- yl}phenyl)methanol 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-[5-(1,1- dimethylethyl)-4H-1,2,4-triazol-3-yl]pyrazin-2-amine (3-{5-amino-6-[3-(2-thienyl)-1H-1,2,4-triazol-5-yl]pyrazin-2-yl}phenyl)me- thanol 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-{3-[3- (methyloxy)phenyl]-1H-1,2,4-triazol-5-yl}pyrazin-2-amine 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-[3- (dimethylamino)propyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-[3-(1- H- imidazol-1-yl)propyl]pyrazine-2-carboxamide 3-{5-amino-6-[(4-chloro-3-fluorophenyl)carbonyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-(5-amino-6-{[2,4-bis(methyloxy)phenyl]carbonyl}pyrazin-2-yl)-N- (phenylmethyl)benzamide 3-(5-amino-6-{[4-(dimethylamino)phenyl]carbonyl}pyrazin-2-yl)-N- (phenylmethyl)benzamide methyl 1-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}-L-prolinate methyl 1-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}piperidine-3-carboxylate 1,1-dimethylethyl 4-{[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}piperazine-1-- carboxylate 3-[5-amino-6-(piperazin-1-ylcarbonyl)pyrazin-2-yl]-N-(phenylmethyl)benzam- ide N-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}glutamic acid 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-{5- [(methyloxy)methyl]-4H-1,2,4-triazol-3-yl}pyrazin-2-amine 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(3-pyridin-3-- yl-1H- 1,2,4-triazol-5-yl)pyrazin-2-amine 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-[3- (methylamino)propyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-(3- pyrrolidin-1-ylpropyl)pyrazine-2-carboxamide 3-(5-amino-6-{(1E)-N-[4-(methyloxy)phenyl]ethanehydrazonoyl}pyrazin-2-yl)- -N- (phenylmethyl)benzamide

3-(5-amino-6-{(1E)-N-[4-(1-methylethyl)phenyl]ethanehydrazonoyl}pyrazin-2- -yl)- N-(phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-1,3-benzothiazol-2-ylethanehydrazonoyl]pyrazin-2-yl}- -N- (phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-(4-methylphenyl)ethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-(4-chlorophenyl)ethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-methyl-N-phenylethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-(2-hydroxyethyl)ethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide {3-[5-amino-6-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)pyrazin-2-yl]phenyl}m- ethanol {3-[5-amino-6-(3-piperidin-4-yl-1H-1,2,4-triazol-5-yl)pyrazin-2- yl]phenyl}methanol 3-[5-amino-6-(2-aminopyrimidin-4-yl)pyrazin-2-yl]-N-(phenylmethyl)benzami- de 3-{5-amino-6-[2-(dimethylamino)pyrimidin-4-yl]pyrazin-2-yl}-N- (phenylmethyl)benzamide ethyl N-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}-L-tyrosinate N-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbo- nyl}- D-tyrosine 1,1-dimethylethyl [3-({[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}amino)propyl]carbamate 3-amino-N-(3-aminopropyl)-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 1-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}piperidine-3-carboxylic 1,1-dimethylethyl [2-({[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}amino)ethyl]carbamate 3-amino-N-(2-aminoethyl)-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 1,1-dimethylethyl (1-{[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}piperidin-4- yl)carbamate 3-{5-amino-6-[(4-aminopiperidin-1-yl)carbonyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[imino(2-phenylhydrazino)methyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[imino(morpholin-4-ylamino)methyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-(5-amino-6-{imino[(4-methylpiperazin-1-yl)amino]methyl}pyrazin-2-yl)-N-- (phenylmethyl)benzamide 3-{5-amino-6-[imino(piperidin-1-ylamino)methyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[(azepan-1-ylamino)(imino)methyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[imino({(2R)-2-[(methyloxy)methyl]pyrrolidin-1- yl}amino)methyl]pyrazin-2-yl}-N-(phenylmethyl)benzamide {3-[5-amino-6-(3-piperidin-3-yl-1H-1,2,4-triazol-5-yl)pyrazin-2- yl]phenyl}methanol 3-{5-amino-6-[(1E)-N-morpholin-4-ylethanimidoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 4-((2E)-2-{1-[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-- 2- yl]ethylidene}hydrazino)benzoic acid ethyl ((2E)-2-{1-[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyra- zin- 2-yl]ethylidene}hydrazino)acetate 3-{5-amino-6-[(1E)-N,N-dimethylethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-(5-amino-6-{(1E)-N-[4-(methylsulfonyl)phenyl]ethanehydrazonoyl}pyrazin-- 2- yl)-N-(phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-(4-cyanophenyl)ethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-pyridin-2-ylethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-(5-amino-6-{(1E)-N-[amino(imino)methyl]ethanehydrazonoyl}pyrazin-2-yl)-- N- (phenylmethyl)benzamide 3-[5-amino-6-((1E)-N-{4- [(trifluoromethyl)oxy]phenyl}ethanehydrazonoyl)pyrazin-2-yl]-N- (phenylmethyl)benzamide 3-(5-Amino-6-{1-[(4-nitro-phenyl)-hydrazono]-ethyl}-pyrazin-2-yl)-N-benzy- l- benzamide 3-(5-amino-6-{(1E)-N-[4-(trifluoromethyl)pyrimidin-2- yl]ethanehydrazonoyl}pyrazin-2-yl)-N-(phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-1H-1,2,3-benzotriazol-1-ylethanimidoyl]pyrazin-2-yl}- -N- (phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-methylethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(3-piperidin-- 4-yl- 1H-1,2,4-triazol-5-yl)pyrazin-2-amine 3-(5-amino-6-{(1E)-N-[4-(trifluoromethyl)phenyl]ethanehydrazonoyl}pyrazin- -2- yl)-N-(phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-phenylethanehydrazonoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-(4-methylpiperazin-1-yl)ethanimidoyl]pyrazin-2-yl}-N- - (phenylmethyl)benzamide {3-[5-amino-6-(3-pyrrolidin-3-yl-1H-1,2,4-triazol-5-yl)pyrazin-2- yl]phenyl}methanol 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- R)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- 1-(furan-2-ylcarbonyl)pyrrolidin-3-yl]pyrazine-2-carboxamide N-[3-(acetylamino)propyl]-3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-{3-[(furan-2-ylcarbonyl)amino]propyl}-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- 1-(pyridin-4-ylcarbonyl)pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-{3-[(pyridin-4- ylcarbonyl)amino]propyl}pyrazine-2-carboxamide N-[3-({[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}amino)propyl]quinoxaline-2-carboxamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-[3-({[6- (trifluoromethyl)pyridin-3-yl]carbonyl}amino)propyl]pyrazine-2-carboxamid- e 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-{3-[(quinolin-8- ylsulfonyl)amino]propyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-{3-[(pyridin-2- ylsulfonyl)amino]propyl}pyrazine-2-carboxamide 3-amino-N-[3-({[(3,5-dimethylisoxazol-4-yl)amino]carbonyl}amino)propyl]-6- -(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-[5-amino-6-(2-methylpyrimidin-4-yl)pyrazin-2-yl]-N-(phenylmethyl)benzam- ide 3-{5-amino-6-[2-(methylamino)pyrimidin-4-yl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-{2-[(pyridin-4- ylcarbonyl)amino]ethyl}pyrazine-2-carboxamide 3-amino-N-{2-[(furan-2-ylcarbonyl)amino]ethyl}-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide N,N'-cyclohexane-1,2-diylbis[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide] N-[2-(acetylamino)ethyl]-3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-{2-[(quinolin-8- ylsulfonyl)amino]ethyl}pyrazine-2-carboxamide N-[2-({[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}amino)ethyl]quinoxaline-2-carboxamide 3-amino-N-(2-{[(2-chloropyridin-3-yl)carbonyl]amino}ethyl)-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-{2-[(pyridin-2- ylsulfonyl)amino]ethyl}pyrazine-2-carboxamide 3-amino-N-[2-({[(3,5-dimethylisoxazol-4-yl)amino]carbonyl}amino)ethyl]-6-- (3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide- 3-[5-amino-6-(imino{2-[4-(trifluoromethyl)pyrimidin-2- yl]hydrazino}methyl)pyrazin-2-yl]-N-(phenylmethyl)benzamide 3-{5-amino-6-[[2-(1,3-benzothiazol-2-yl)hydrazino](imino)methyl]pyrazin-2- -yl}-N- (phenylmethyl)benzamide 3-[5-amino-6-(1,5-diphenyl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]-N- (phenylmethyl)benzamide 3-[5-amino-6-(1,5-dimethyl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]-N- (phenylmethyl)benzamide 3-[5-amino-6-(1-methyl-5-phenyl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]-N- (phenylmethyl)benzamide 3-[5-amino-6-((1E)-N-{(2R)-2-[(methyloxy)methyl]pyrrolidin-1- yl}ethanimidoyl)pyrazin-2-yl]-N-(phenylmethyl)benzamide 3-{5-amino-6-[(1E)-N-azepan-1-ylethanimidoyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-(5-amino-6-{(E)-[(phenylmethyl)hydrazono]methyl}pyrazin-2-yl)-N- (phenylmethyl)benzamide 3-[5-amino-6-((E)-{[amino(imino)methyl]hydrazono}methyl)pyrazin-2-yl]-N- (phenylmethyl)benzamide 3-(5-amino-6-{(E)-[(2-hydroxyethyl)hydrazono]methyl}pyrazin-2-yl)-N- (phenylmethyl)benzamide 3-{5-amino-6-[(E)-(pyridin-2-ylhydrazono)methyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-(5-amino-6-{(E)-[(4-cyanophenyl)hydrazono]methyl}pyrazin-2-yl)-N- (phenylmethyl)benzamide 3-(5-amino-6-{(E)-[(4-methylphenyl)hydrazono]methyl}pyrazin-2-yl)-N- (phenylmethyl)benzamide 3-{5-amino-6-[(E)-(hydroxyimino)methyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide {3-[5-amino-6-(3-pyridin-2-yl-1H-1,2,4-triazol-5-yl)pyrazin-2-yl]phenyl}m- ethanol 5-(3-{[(1R)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(3-piperidin-- 3-yl- 1H-1,2,4-triazol-5-yl)pyrazin-2-amine 3-amino-N-[3-({[4-(dimethylamino)phenyl]carbonyl}amino)propyl]-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-N-[(3S)- - pyrrolidin-3-yl]pyrazine-2-carboxamide 1,1-dimethylethyl 4-[(3S)-3-({[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrroli- din- 1-yl]piperidine-1-carboxylate 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-[(3S)-1-piperidin-4- - ylpyrrolidin-3-yl]pyrazine-2-carboxamide 1,1-dimethylethyl (2R)-2-{[(3S)-3-({[3-amino-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrroli- din- 1-yl]methyl}pyrrolidine-1-carboxylate 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-{(3S)-1-[(2R)- pyrrolidin-2-ylmethyl]pyrrolidin-3-yl}pyrazine-2-carboxamide 3-amino-N-((3S)-1-{[4-(dimethylamino)phenyl]methyl}pyrrolidin-3-yl)-6-(3-- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-{2-[({[4-(dimethylamino)phenyl]amino}carbonyl)amino]ethyl}-6-(3- - {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-[2-({[4-(dimethylamino)phenyl]carbonyl}amino)ethyl]-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-{5-amino-6-[imino(2-pyridin-2-ylhydrazino)methyl]pyrazin-2-yl}-N- (phenylmethyl)benzamide 3-[5-amino-6-(morpholin-4-ylmethyl)pyrazin-2-yl]-N-(phenylmethyl)benzamid- e ethyl 1-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]methyl}piperidine-4-carboxylate 3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)-N-[(3S)-1-(pyridin-2-- ylmethyl)pyrrolidin-3-yl]pyrazine-2-carboxamide methyl N-{[3-amino-6-(3-{[(phenylmethyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}threoninate {3-[5-amino-6-(3-piperidin-2-yl-1H-1,2,4-triazol-5-yl)pyrazin-2- yl]phenyl}methanol 3-(ethylamino)-N-[(3S)-1-ethylpyrrolidin-3-yl]-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-[(3S)-1-ethylpyrrolidin-3-yl]-6-(3- {[(phenylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-[5-amino-6-(1-methyl-5-piperidin-2-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-y- l]-N- (phenylmethyl)benzamide 3-[5-amino-6-(5-methyl-1-pyridin-2-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]- -N- (phenylmethyl)benzamide {3-[5-amino-6-(3-morpholin-2-yl-1H-1,2,4-triazol-5-yl)pyrazin-2- yl]phenyl}methanol 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-{3-[(3S)-pipe- ridin- 3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-amine 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-{3-[(3R)-pipe- ridin- 3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-amine

3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- 1-ethylpyrrolidin-3-yl]pyrazine-2-carboxamide 6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-3-(ethylamino- )-N- [(3S)-1-ethylpyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[(3S)-pyrrolidin-3-yl]pyrazine-2-carboxamide 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrrolidine-1-carboxy- late 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-({[(1R)-1- phenylethyl]amino}carbonyl)phenyl]pyrazin-2-yl}carbonyl)amino]pyrrolidine- -1- carboxylate 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-(3,4-dihydroisoquinolin-2(1H)- ylcarbonyl)phenyl]pyrazin-2-yl}carbonyl)amino]pyrrolidine-1-carboxylate 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[(2- phenylethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrrolidine- -1- carboxylate 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-({[(1S)-1- phenylethyl]amino}carbonyl)phenyl]pyrazin-2-yl}carbonyl)amino]pyrrolidine- -1- carboxylate 3-amino-6-[3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)phenyl]-N-[(3S)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2-phenylethyl)amino]carbonyl}phenyl)-N-[(3S)-pyrrolidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1R)-1-phenylethyl]amino}carbonyl)phenyl]-N-[(3S)-pyrroli- din-3- yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1S)-1-phenylethyl]amino}carbonyl)phenyl]-N-[(3S)-pyrroli- din-3- yl]pyrazine-2-carboxamide 3-{5-amino-6-[(2-ethylhydrazino)(imino)methyl]pyrazin-2-yl}-N-(2,3-dihydr- o-1H- inden-1-yl)benzamide 3-{5-amino-6-[imino(2-methylhydrazino)methyl]pyrazin-2-yl}-N-[(1S)-2,3- dihydro-1H-inden-1-yl]benzamide 3-{5-amino-6-[imino(2-phenylhydrazino)methyl]pyrazin-2-yl}-N-[(1S)-2,3- dihydro-1H-inden-1-yl]benzamide phenylmethyl 3-{3-[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]-1-methyl-1H-1,2,4-triazol-5-yl}pipe- ridine- 1-carboxylate phenylmethyl 3-{3-[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]-1-ethyl-1H-1,2,4-triazol-5-yl}piper- idine-1- carboxylate 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(3-pyridin-4-- yl-1H- 1,2,4-triazol-5-yl)pyrazin-2-amine [3-(5-amino-6-{3-[(3R)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- yl)phenyl]methanol [3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- yl)phenyl]methanol 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[(3S)-pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-1-ethylpyrrolidin-3-yl]-6-[3-({[(1S,2R)-2-hydroxy-2,3-dih- ydro- 1H-inden-1-yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 1,1-dimethylethyl 3-({[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)piperidine-1-carboxyl- ate 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N- piperidin-3-ylpyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-(1-- ethylpiperidin-3-yl)pyrazine-2-carboxamide 3-amino-N-[(3S)-1-ethylpyrrolidin-3-yl]-6-[3-({[(1R,2S)-2-hydroxy-2,3-dih- ydro- 1H-inden-1-yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide (3-{5-amino-6-[5-(1-ethylpiperidin-3-yl)-4H-1,2,4-triazol-3-yl]pyrazin-2-- yl}phenyl)methanol 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-[5-(1- ethylpiperidin-3-yl)-4H-1,2,4-triazol-3-yl]pyrazin-2-amine 3-[5-amino-6-(1-ethyl-5-piperidin-3-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl- ]-N-[(1R)- 2,3-dihydro-1H-inden-1-yl]benzamide 3-[5-amino-6-(1-methyl-5-piperidin-3-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-y- l]-N- [(1S)-2,3-dihydro-1H-inden-1-yl]benzamide (3-{5-amino-6-[3-(1-methylpiperidin-3-yl)-1H-1,2,4-triazol-5-yl]pyrazin-2- - yl}phenyl)methanol 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-[3-(1- methylpiperidin-3-yl)-1H-1,2,4-triazol-5-yl]pyrazin-2-amine 1,1-dimethylethyl (3S)-3-{[(3-amino-6-{3-[({[4- (methyloxy)phenyl]methyl}amino)carbonyl]phenyl}pyrazin-2- yl)carbonyl]amino}pyrrolidine-1-carboxylate 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[({4- [(trifluoromethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazin-2- yl]carbonyl}amino)pyrrolidine-1-carboxylate 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-({[(2-chloro-6- fluorophenyl)methyl]amino}carbonyl)phenyl]pyrazin-2- yl}carbonyl)amino]pyrrolidine-1-carboxylate 1,1-dimethylethyl (3S)-3-{[(3-amino-6-{3-[({[4- (methylthio)phenyl]methyl}amino)carbonyl]phenyl}pyrazin-2- yl)carbonyl]amino}pyrrolidine-1-carboxylate 1,1-dimethylethyl (3S)-3-{[(3-amino-6-{3-[(2,3-dihydro-1H-inden-2- ylamino)carbonyl]phenyl}pyrazin-2-yl)carbonyl]amino}pyrrolidine-1-carboxy- late 3-amino-6-{3-[({[4-(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S- )- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-pyrrolidin-3-yl]-6-(3-{[({4- [(trifluoromethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-{3-[(2,3-dihydro-1H-inden-2-ylamino)carbonyl]phenyl}-N-[(3S)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2-chloro-6-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-(methylthio)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3- S)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-{5-amino-6-[imino(2-pyridin-4-ylhydrazino)methyl]pyrazin-2-yl}-N-[(1R)-- 2,3- dihydro-1H-inden-1-yl]benzamide phenylmethyl (3R)-3-{3-[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]-1-ethyl-1H-1,2,4-triazol-5-yl}piper- idine-1- carboxylate 3-amino-6-(3-{(1S)-1-[(1S)-2,3-dihydro-1H-inden-1-ylamino]ethyl}phenyl)-N- - methylpyrazine-2-carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[2-(1H-imidazol-4-yl)ethyl]pyrazine-2-carboxa- mide 1,1-dimethylethyl (3S)-3-[({[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)methyl]pyrrolidine-1-- carboxylate 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- R)- pyrrolidin-3-ylmethyl]pyrazine-2-carboxamide phenylmethyl (3R)-3-{3-[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]-1-methyl-1H-1,2,4-triazol-5-yl}pipe- ridine- 1-carboxylate 3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-yl)- -N-[(1S)- 2,3-dihydro-1H-inden-1-yl]benzamide 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-({[(4- chlorophenyl)methyl]amino}carbonyl)phenyl]pyrazin-2- yl}carbonyl)amino]pyrrolidine-1-carboxylate 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[(pyridin-2- ylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrrolidine-1-- carboxylate 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[(pyridin-3- ylmethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrrolidine-1-- carboxylate 1,1-dimethylethyl (3S)-3-{[(3-amino-6-{3-[(3,4-dihydro-2H-chromen-4- ylamino)carbonyl]phenyl}pyrazin-2-yl)carbonyl]amino}pyrrolidine-1-carboxy- late 3-amino-6-[3-({[(4-chlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(pyridin-2-ylmethyl)amino]carbonyl}phenyl)-N-[(3S)-pyrroli- din-3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(pyridin-3-ylmethyl)amino]carbonyl}phenyl)-N-[(3S)-pyrroli- din-3- yl]pyrazine-2-carboxamide dimethyl 5-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}benzene-1,3- dicarboxylate 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- R)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-piperidin-3-ylpyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[2-- (1H- imidazol-4-yl)ethyl]pyrazine-2-carboxamide 3-amino-N-azepan-4-yl-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazine-2-carboxamide 1,1-dimethylethyl (3S)-3-{[({3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H- inden-1-yl]amino}carbonyl)phenyl]pyrazin-2- yl}carbonyl)amino]methyl}pyrrolidine-1-carboxylate 1,1-dimethylethyl 4-({[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)azepane-1-carboxylate- 3-[5-amino-6-(5-{2-[(phenylmethyl)oxy]ethyl}-1H-1,2,4-triazol-3-yl)pyrazi- n-2-yl]- N-[(1S)-2,3-dihydro-1H-inden-1-yl]benzamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}-4-fluorophen- yl)- N-methylpyrazine-2-carboxamide 3-[5-amino-6-(1-phenyl-5-piperidin-3-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-y- l]-N- [(1S)-2,3-dihydro-1H-inden-1-yl]benzamide 3-{5-amino-6-[amino(imino)methyl]pyrazin-2-yl}-N-[(1S)-2,3-dihydro-1H-ind- en- 1-yl]benzamide 3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-yl)- -N- [(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]benzamide 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)piperidine-1-carboxyl- ate 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H- inden-1-yl]amino}carbonyl)phenyl]pyrazin-2-yl}carbonyl)amino]piperidine-1- - carboxylate 3-amino-6-{3-[(3,4-dihydro-2H-chromen-4-ylamino)carbonyl]phenyl}-N-[(3S)-- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[(2,3-dihydro-1-benzofuran-3-ylamino)carbonyl]phenyl}-N-[(3S- )- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[(3R)-pyrrolidin-3-ylmethyl]pyrazine-2-carbox- amide 1,1-dimethylethyl 4-[({3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden- 1-yl]amino}carbonyl)phenyl]pyrazin-2-yl}carbonyl)amino]azepane-1-carboxyl- ate 3-amino-N-azepan-4-yl-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-azepan-4-yl-6-{3-[(3aR,8aS)-8,8a-dihydro-3aH-indeno[1,2- d][1,3]oxazol-2-yl]phenyl}pyrazine-2-carboxamide 1,1-dimethylethyl (3R)-3-[({[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)methyl]pyrrolidine-1-- carboxylate 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- pyrrolidin-3-ylmethyl]pyrazine-2-carboxamide 1,1-dimethylethyl (3R)-3-{[({3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H- inden-1-yl]amino}carbonyl)phenyl]pyrazin-2- yl}carbonyl)amino]methyl}pyrrolidine-1-carboxylate 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[(3S)-pyrrolidin-3-ylmethyl]pyrazine-2-carbox- amide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}-5-fluorophen- yl)- N-methylpyrazine-2-carboxamide 3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}-5- [(methyloxy)carbonyl]benzoic acid methyl 3-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}-5-{[(1S)-2,3-dih- ydro-

1H-inden-1-ylamino]carbonyl}benzoate 5-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}-N-[(1S)-2,3-dihydro-1H-- inden-1-yl]-N'-pyrrolidin-3-ylbenzene-1,3-dicarboxamide 3-[5-amino-6-(5-phenyl-1-pyridin-2-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]- -N- (phenylmethyl)benzamide 3-[5-amino-6-(5-methyl-1-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]- -N-[(1S)- 2,3-dihydro-1H-inden-1-yl]benzamide 1,1-dimethylethyl (3R)-3-({[3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)piperidine-1-carboxyl- ate 1,1-dimethylethyl (3R)-3-[({3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H- inden-1-yl]amino}carbonyl)phenyl]pyrazin-2-yl}carbonyl)amino]piperidine-1- - carboxylate 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- piperidin-3-yl]pyrazine-2-carboxamide 5-{5-amino-6-[(methylamino)carbonyl]pyrazin-2-yl}-N-[(1R)-2,3-dihydro-1H-- inden-1-yl]-N'-[(3R)-pyrrolidin-3-yl]benzene-1,3-dicarboxamide (3-{5-amino-6-[3-(2-aminopyridin-4-yl)-1H-1,2,4-triazol-5-yl]pyrazin-2- yl}phenyl)methanol 3-[5-amino-6-(1,5-dimethyl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]-N-[(1S)-2,- 3- dihydro-1H-inden-1-yl]benzamide 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[(1-methyl-1- phenylethyl)amino]carbonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrrolidine- -1- carboxylate 3-amino-6-(3-{[(1-methyl-1-phenylethyl)amino]carbonyl}phenyl)-N-[(3S)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]sulfonyl}phenyl)pyrazi- ne-2- carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]sulfonyl}phenyl)-N- piperidin-3-ylpyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- 1-methylpyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[(3S)-1-methylpyrrolidin-3-yl]pyrazine-2- carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]-N-[(3S)-pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-pyrrolidin-3-yl]-6-(3-{[(1S)-1,2,3,4-tetrahydronaphthalen- -1- ylamino]methyl}phenyl)pyrazine-2-carboxamide N-[3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-- yl)phenyl]-2-(2,4-dichlorophenyl)acetamide 1,1-dimethylethyl (3S)-3-({[3-amino-6-(3-{[(1R)-2,3-dihydro-1H-inden-1- ylamino]sulfonyl}phenyl)pyrazin-2-yl]carbonyl}amino)pyrrolidine-1-carboxy- late 3-amino-6-(3-hydroxyphenyl)-N-[(3S)-pyrrolidin-3-yl]pyrazine-2-carboxamid- e 3-amino-6-(3-{[(1R)-2,3-dihydro-1H-inden-1-ylamino]sulfonyl}phenyl)-N-[(3- S)- pyrrolidin-3-yl]pyrazine-2-carboxamide 3-[5-amino-6-(1-pyridin-4-yl-1H-1,2,4-triazol-3-yl)pyrazin-2-yl]-N-[(1S)-- 2,3- dihydro-1H-inden-1-yl]benzamide 3-amino-N-[(3S)-pyrrolidin-3-yl]-6-[3-({[(3,4,5- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-pyrrolidin-3-yl]-6-[3-({[(2,3,6- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-pyrrolidin-3-yl]-6-[3-({[(2,3,5- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-bromo-4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- [(3S)-pyrrolidin-3-yl]pyrazine-2-carboxamide 3-{5-amino-6-[3-(1-methylpiperidin-3-yl)-1H-1,2,4-triazol-5-yl]pyrazin-2-- yl}-N-[(2- chloro-6-fluorophenyl)methyl]benzamide 3-amino-N-1-azabicyclo[2.2.2]oct-3-yl-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-- ylamino]methyl}phenyl)pyrazine-2-carboxamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(4- chloro-2-fluorophenyl)methyl]benzamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(2- chlorophenyl)methyl]benzamide 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-({[(2,4- dichlorophenyl)methyl]amino}carbonyl)phenyl]pyrazin-2- yl}carbonyl)amino]pyrrolidine-1-carboxylate 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-({[(3,4- dichlorophenyl)methyl]amino}carbonyl)phenyl]pyrazin-2- yl}carbonyl)amino]pyrrolidine-1-carboxylate 5-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]methyl}phenyl)-3-(4-piperidin-- 3-yl- 1,3-thiazol-2-yl)pyrazin-2-amine 3-amino-6-[3-({[(2,4-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - pyrrolidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3,4-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - pyrrolidin-3-yl]pyrazine-2-carboxamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(2,6- difluorophenyl)methyl]benzamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(2- chloro-6-fluorophenyl)methyl]benzamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(2,5- dichlorophenyl)methyl]benzamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(3,4- dichlorophenyl)methyl]benzamide 3-amino-6-{3-[({[4-(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S- )- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 1,1-dimethylethyl (3S)-3-{[(3-amino-6-{3-[({[(1,1- dimethylethyl)oxy]carbonyl}amino)methyl]phenyl}pyrazin-2- yl)carbonyl]amino}piperidine-1-carboxylate 3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-yl)- -N-[(2- fluorophenyl)methyl]benzamide 3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-yl)- -N-[(3- fluorophenyl)methyl]benzamide 3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-yl)- -N-[(4- fluorophenyl)methyl]benzamide 3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-yl)- -N-[(3- chlorophenyl)methyl]benzamide 3-(5-amino-6-{5-[(3S)-piperidin-3-yl]-4H-1,2,4-triazol-3-yl}pyrazin-2-yl)- -N-[(4- chlorophenyl)methyl]benzamide 3-amino-6-[3-(aminomethyl)phenyl]-N-[(3S)-piperidin-3-yl]pyrazine-2- carboxamide 3-amino-6-(3-hydroxyphenyl)-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxamide- 1,1-dimethylethyl (3S)-3-[({3-amino-6-[3-(aminomethyl)phenyl]pyrazin-2- yl}carbonyl)amino]piperidine-1-carboxylate 3-amino-6-[3-({[(4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[({4- [(trifluoromethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-(3-{[(biphenyl-4-ylmethyl)amino]carbonyl}phenyl)-N-[(3S)-piperi- din-3- yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[4-(1,2,3-thiadiazol-5- yl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[({2- [(trifluoromethyl)oxy]phenyl}methyl)amino]carbonyl}phenyl)pyrazine-2- carboxamide 3-amino-6-(3-{[(biphenyl-2-ylmethyl)amino]carbonyl}phenyl)-N-[(3S)-piperi- din-3- yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-difluorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-chloro-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-fluoro-3- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(naphthalen-2-ylmethyl)amino]carbonyl}phenyl)-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-(dimethylamino)phenyl]methyl}amino)carbonyl]phenyl}-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1,3-benzodioxol-5-ylmethyl)amino]carbonyl}phenyl)-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[4-(2- thienyl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-{3-[({[2-(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S- )- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[2,4-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-chloro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-difluoro-4-methylphenyl)methyl]amino}carbonyl)phenyl- ]-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-(methylsulfonyl)phenyl]methyl}amino)carbonyl]phenyl}-N- - [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2,3-dihydro-1,4-benzodioxin-6- ylmethyl)amino]carbonyl}phenyl)-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxa- mide 3-amino-6-[3-({[(4-chlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(5-chloro-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-6-(3-{[(1S)-2,3-dihydro-1H-i- nden- 1-ylamino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-{3-[({[4-(methylthio)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3- S)- piperidin-3-yl]pyrazine-2-carboxamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(2,4- difluorophenyl)methyl]benzamide 3-amino-6-(3-{[(1,2-diphenylethyl)amino]carbonyl}phenyl)-N-[(3S)-piperidi- n-3- yl]pyrazine-2-carboxamide 3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2-yl)- -N-[(3,4- difluorophenyl)methyl]benzamide 3-amino-6-[3-({[(3,5-difluorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide methyl 4-[({[3-(5-amino-6-{[(3S)-piperidin-3-ylamino]carbonyl}pyrazin-2- yl)phenyl]carbonyl}amino)methyl]benzoate 3-amino-6-[3-({[(4-bromophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-bromo-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2-bromophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-fluoro-2- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[2-fluoro-3- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[(3R)-pyrrolidin-3- ylmethyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[(3R)-pyrrolidin-3- ylamino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[(2-piperidin-1- ylethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(2-phenylethyl)amino]carbonyl}phenyl)-N-[(3S)-piperidin-3-- yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2-methyloxy)ethyl]amino}carbonyl)phenyl]-N-[(3S)-piperid- in-3- yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-iodophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)-piper- idin-

3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2-chlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-fluorophenyl)carbonyl]amino}methyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[({4- [(trifluoromethyl)oxy]phenyl}carbonyl)amino]methyl}phenyl)pyrazine-2- carboxamide 3-amino-6-[3-({[(4-chlorophenyl)carbonyl]amino}methyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(4-chlorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2,6-dichlorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin- -3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(pentafluorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin-- 3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2-chloro-4-fluorophenyl)acetyl]amino}phenyl)-N-[(3S)-pipe- ridin- 3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[4-(methylthio)phenyl]acetyl}amino)phenyl]-N-[(3S)-piperid- in-3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2,4-dichlorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin- -3- yl]pyrazine-2-carboxamide 3-amino-6-[3-({[4-(4-chlorophenyl)-2-thienyl]carbonyl}amino)phenyl]-N-[(3- S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-bromophenyl)carbonyl]amino}methyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(naphthalen-2-ylcarbonyl)amino]methyl}phenyl)-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[2-(4-phenylpiperazin-1-yl)ethyl]oxy}phenyl)-N-[(3S)-piperi- din-3- yl]pyrazine-2-carboxamide N-[(3-{5-amino-6-[(3R)-piperidin-3-ylacetyl]pyrazin-2-yl}phenyl)methyl]-N- '-(4- bromophenyl)urea N-[(3-{5-amino-6-[(3R)-piperidin-3-ylacetyl]pyrazin-2-yl}phenyl)methyl]-N- '- naphthalen-2-ylurea 3-amino-6-(3-{[(2,4-difluorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin- -3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2-fluorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-6-{3-[({5-[2-chloro-5-(trifluoromethyl)phenyl]furan-2- yl}carbonyl)amino]phenyl}-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[4-(dimethylamino)naphthalen-1-yl]carbonyl}amino)phenyl]-N- - [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[4-(1,2,3-thiadiazol-5- yl)phenyl]carbonyl}amino)phenyl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)-N-[(3- S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-(dimethylamino)phenyl]carbonyl}amino)methyl]phenyl}-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[(2-hydroxyethyl)oxy]phenyl}-N-[(3S)-piperidin-3-yl]pyrazine- -2- carboxamide 3-amino-6-(3-{[(2,3-dihydro-1-benzofuran-5-ylsulfonyl)amino]methyl}phenyl- )-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(3,4-dihydro-2H-1,5-benzodioxepin-7- ylsulfonyl)amino]methyl}phenyl)-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxa- mide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[(quinolin-7- ylsulfonyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-[3-({[(biphenyl-4-ylamino)carbonyl]amino}methyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(4-bromo-2-fluorophenyl)carbonyl]amino}phenyl)-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide N-[3-(5-amino-6-{[(3S)-piperidin-3-ylamino]carbonyl}pyrazin-2- yl)phenyl]quinoline-3-carboxamide 3-amino-6-[3-({[6-(methyloxy)-1-benzofuran-3-yl]acetyl}amino)phenyl]-N-[(- 3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[4'-(trifluoromethyl)biphenyl-2- yl]carbonyl}amino)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[3,5-bis(trifluoromethyl)phenyl]acetyl}amino)phenyl]-N-[(3- S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[(2,4-difluorophenyl)amino]carbonyl}amino)methyl]phenyl}-- N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[2- (trifluoromethyl)phenyl]sulfonyl}amino)methyl]phenyl}pyrazine-2-carboxami- de 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[({4- [(trifluoromethyl)oxy]phenyl}sulfonyl)amino]methyl}phenyl)pyrazine-2- carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[({2- [(trifluoromethyl)oxy]phenyl}sulfonyl)amino]methyl}phenyl)pyrazine-2- carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[4- (trifluoromethyl)phenyl]sulfonyl}amino)methyl]phenyl}pyrazine-2-carboxami- de 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[({2- [(trifluoromethyl)oxy]phenyl}amino)carbonyl]amino}methyl)phenyl]pyrazine-- 2- carboxamide 3-amino-6-(3-{[({[2-(methylthio)phenyl]amino}carbonyl)amino]methyl}phenyl- )-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[(3-bromo-5- methylphenyl)amino]carbonyl}amino)methyl]phenyl}-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[(2-bromophenyl)amino]carbonyl}amino)methyl]phenyl}-N-[(3- S)- piperidin-3-yl]pyrazine-2-carboxamide 5-[3-(aminomethyl)phenyl]-3-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5- yl}pyrazin-2-amine 3-amino-6-{3-[({[4-(4-methylpiperazin-1- yl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3-yl]pyrazine-2- - carboxamide 3-amino-6-[3-({[2-(4-fluorophenyl)ethyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2-morpholin-4-ylethyl)amino]carbonyl}phenyl)-N-[(3S)-pipe- ridin- 3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[(2R)-pyrrolidin-2- ylmethyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[(2S)-pyrrolidin-2- ylamino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-{3-[(cyclopentylamino)carbonyl]phenyl}-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[({4- [(trifluoromethyl)oxy]phenyl}amino)carbonyl]amino}methyl)phenyl]pyrazine-- 2- carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[({[4- (trifluoromethyl)phenyl]amino}carbonyl)amino]methyl}phenyl)pyrazine-2- carboxamide 3-amino-6-{3-[({[4-(methyloxy)phenyl]carbonyl}amino)methyl]phenyl}-N-[(3S- )- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(biphenyl-4-ylcarbonyl)amino]methyl}phenyl)-N-[(3S)-piperi- din-3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(furan-2-ylcarbonyl)amino]methyl}phenyl)-N-[(3S)-piperidin- -3- yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-dihydro-1,4-benzodioxin-6- ylamino)carbonyl]amino}methyl)phenyl]-N-[(3S)-piperidin-3-yl]pyrazine-2- carboxamide 3-amino-6-(3-{[(2,3-dihydro-1-benzofuran-5-ylcarbonyl)amino]methyl}phenyl- )-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)amino]methyl}phe- nyl)- N-[(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[(2- thienylcarbonyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(2,3-dihydro-1,4-benzodioxin-2- ylcarbonyl)amino]methyl}phenyl)-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxa- mide N-{[3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- - yl)phenyl]methyl}-2-chlorobenzamide N-{[3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- - yl)phenyl]methyl}-4-chlorobenzamide N-{[3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- - yl)phenyl]methyl}-4-iodobenzamide N-{[3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- - yl)phenyl]methyl}-3,5-difluorobenzamide N-{[3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- - yl)phenyl]methyl}-4-bromo-2-fluorobenzamide N-{[3-(5-amino-6-{3-[(3S)-piperidin-3-yl]-1H-1,2,4-triazol-5-yl}pyrazin-2- - yl)phenyl]methyl}-4-bromo-2-chlorobenzamide 3-[3-(2-aminopyridin-4-yl)-1H-1,2,4-triazol-5-yl]-5-(3-{[(1S)-2,3-dihydro- -1H- inden-1-ylamino]methyl}phenyl)pyrazin-2-amine 3-amino-N-azepan-3-yl-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[2-(2-thienyl)-1,3-thiazol-4- yl]carbonyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[5-(2-thienyl)pyridin-3- yl]carbonyl}amino)methyl]phenyl}pyrazine-2-carboxamide 3-amino-6-{3-[({[4-(1,1-dimethylethyl)phenyl]methyl}amino)carbonyl]phenyl- }-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-dichloro-6-methylphenyl)methyl]amino}carbonyl)phenyl- ]-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3,5-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[(2- thienylsulfonyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-(3-{[(3- thienylsulfonyl)amino]methyl}phenyl)pyrazine-2-carboxamide 3-amino-6-[3-({[(4-chlorophenyl)sulfonyl]amino}methyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1,3-benzodioxol-5-ylamino)carbonyl]amino}methyl)phenyl]-- N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[({[4-(methyloxy)phenyl]amino}carbonyl)amino]methyl}phenyl)- -N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[(4-fluorophenyl)amino]carbonyl}amino)methyl]phenyl}-N-[(- 3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[2-(diethylamino)ethyl]oxy}phenyl)-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-6-{3-[(2-morpholin-4-ylethyl)oxy]phenyl}-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-6-[3-(methyloxy)phenyl]-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxa- mide 3-amino-6-[3-(ethyloxy)phenyl]-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxam- ide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[4-(1,2,3-thiadiazol-4- yl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[2-(ethylamino)ethyl]oxy}phenyl)-N-[(3S)-piperidin-3-yl]pyr- azine- 2-carboxamide phenylmethyl 4-(2-{[3-(5-amino-6-{[(3S)-piperidin-3-ylamino]carbonyl}pyrazin-2- yl)phenyl]oxy}ethyl)piperazine-1-carboxylate 3-amino-6-(3-{[({[4- (dimethylamino)phenyl]amino}carbonyl)amino]methyl}phenyl)-N-[(3S)-piperid- in- 3-yl]pyrazine-2-carboxamide 3-amino-N-azepan-3-yl-6-(3-{[(1S)-2,3-dihydro-1H-inden-1- ylamino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-6-[3-({[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}methyl)phenyl]-N-[(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(1S,2S)-2-hydroxy-2,3-dihydro-1H-inden-1- yl]amino}carbonyl)phenyl]-N-[(3S)-1-(phenylmethyl)azepan-3-yl]pyrazine-2-- carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(1S,2S)-2-hydroxy-2,3-dihydro-1H-ind- en- 1-yl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-{3-[({[(4-chlorophenyl)amino]carbonyl}amino)methyl]phenyl}-N-[(- 3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-ylamino]carbonyl}phenyl)-N-[(3- S)- 1-(phenylmethyl)azepan-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-(3-{[(1S)-2,3-dihydro-1H-inden-1-

ylamino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-(3-methylphenyl)pyrazine-2-carboxamide 3-amino-6-(3-{[(2-methylphenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[3- (trifluoromethyl)phenyl]acetyl}amino)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[4-(methyloxy)phenyl]acetyl}amino)phenyl]-N-[(3S)-piperidi- n-3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(6-methylpyridin-3-yl)carbonyl]amino}phenyl)-N-[(3S)-piper- idin- 3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(3-fluorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[(pyridin-3-ylacetyl)amino]phenyl}py- razine- 2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[(pyridin-3- ylcarbonyl)amino]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(2,5-difluorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin- -3- yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(4-fluorophenyl)acetyl]amino}phenyl)-N-[(3S)-piperidin-3- yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[3-fluoro-5- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3,4-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-Amino-6-[3-({[5-(4-nitro-phenyl)-furan-2-carbonyl]-amino}-methyl)-pheny- l]- pyrazine-2-carboxylic acid (3S)-piperidin-3-ylamide 3-amino-6-[3-({[(3-hydroxypyridin-2-yl)carbonyl]amino}methyl)phenyl]-N-[(- 3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[({4- [(trifluoromethyl)oxy]phenyl}oxy)acetyl]amino}methyl)phenyl]pyrazine-2- carboxamide 3-amino-6-[3-({[(5-methylisoxazol-3-yl)carbonyl]amino}methyl)phenyl]-N-[(- 3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-(3-{[(isoxazol-5-ylcarbonyl)amino]methyl}phenyl)-N-[(3S)-piperi- din- 3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-methyl-1,2,3-thiadiazol-5-yl)carbonyl]amino}methyl)phe- nyl]- N-[(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,5-dichloro-3-thienyl)carbonyl]amino}methyl)phenyl]-N-[- (3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(5-chloro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[2-chloro-5- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2-chloro-6-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(4-chloro-2- fluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-2-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[2-fluoro-5- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-difluorophenyl)methyl]amino}methyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-2,6-difluorophenyl)methyl]amino}carbonyl)phenyl- ]-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[2-fluoro-4- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2-chloro-4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[(2,3,6- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-{3-[({[4-chloro-3- (trifluoromethyl)phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(2,3- difluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(3,4- difluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(3,5- difluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,6-difluorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3,4-difluorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(6-chloro-2-fluoro-3- methylphenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)-piperidin-3-yl]pyrazin- e-2- carboxamide 3-amino-6-[3-({[(2-chloro-6-fluoro-3- methylphenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)-piperidin-3-yl]pyrazin- e-2- carboxamide 3-amino-6-[3-({[(2-chloro-3,6-difluorophenyl)methyl]amino}carbonyl)phenyl- ]-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,5-dichlorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[(2,3,4- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,3-difluorophenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-fluoro-4-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(3-chloro-2,6- difluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-(3-{[(2,3-dihydro-1,4-benzodioxin-6- ylmethyl)amino]carbonyl}phenyl)pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(2-chloro-6- fluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(2,6- difluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(3-chloro-4- fluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-[3-({[(3-chloro-2- fluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-chloro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[2,6-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-bromo-4-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[(3,4,5- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(4-fluoro-3-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-[3-({[(2,3,5- trifluorophenyl)methyl]amino}carbonyl)phenyl]pyrazine-2-carboxamide 3-amino-6-[3-({[(5-fluoro-2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-bromo-5-fluorophenyl)methyl]amino}carbonyl)phenyl]-N- [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-piperidin-3-yl]-6-{3-[({[4-(1H-pyrazol-1- yl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide 3-amino-6-(3-{[(biphenyl-3-ylmethyl)amino]carbonyl}phenyl)-N-[(3S)-piperi- din-3- yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2-methylphenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,5-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3,5-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(2,4-dimethylphenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- - piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-[3-({[(3-methoxyphenyl)methyl]amino}carbonyl)phenyl]-N-[(3S)- piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[phenyl]methyl}amino)carbonyl]phenyl}-N-[(3S)-piperidin-3- - yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[3,5-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-6-{3-[({[3,4-bis(methyloxy)phenyl]methyl}amino)carbonyl]phenyl}-N- - [(3S)-piperidin-3-yl]pyrazine-2-carboxamide 3-amino-N-[(3S)-azepan-3-yl]-6-{3-[({[4-(1H-pyrazol-1- yl)phenyl]methyl}amino)carbonyl]phenyl}pyrazine-2-carboxamide.

28. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier.

29. A compound according to the following name: 3-amino-6-[3-({[(2,4-difluorophenyl)methyl]amino}methyl)phenyl]-N-[(3S)-p- iperidin-3- yl]pyrazine-2-carboxamide, or a pharmaceutically acceptable salt thereof.

30. A method of diminishing proliferation of a plurality of cancerous cells in a patient, the method comprising administering to the patient the compound as described in claim 1, and one or more cancer therapeutic agents.

31. The method of claim 30, wherein the compound is combined with a pharmaceutically acceptable carrier.

32. The method of claim 30, wherein the cancer therpeutic agent is selected from the group consisting of a Topoisomerase I inhibitor, a Topoisomerase II inhibitor, an alkylating agent, a nitrogen mustard, an aziridine, an epoxide, an alkyl sulfonate, a nitrosourea, an alkylating agent-steroid conjugate, a DNA damaging/binding agent, a Cisplatin, an antibiotic, an anthracycline, an anthracenedione, an antimetabolite, an antifolate, a nucleic acid analog, a ribonucleic acid analog, a ribozyme, a Vinca alkaloid, a Taxane, an enzyme, a natural product, a kinase inhibitor, a hormone a hormones antagonist, and a biological response modifier.

33. The method of claim 30, wherein where the cancer therapeutic agent comprises at least one of: Camptothecin, Topotecan, 9-Nitrocamptothecin, 9-Aminocamptothecin, Karenitecin, Irinotecan, Etoposide, Etoposide Phosphate, Teniposide, Amsacrine, Razoxane, Dexrazoxane, Mechlorethamine, Cyclophosphamide, Ifosfamide, Chiorambucil, Melphalan, Thiotepa, Trenimon, Triethylenemelamine, Dianhydrogalactitol, Dibromodulcitol, Busulfan, dimethylsulfate, Chloroethylnitrosourea, BCNU, CCNU, Methyl-CCNU, Streptozotocin, Chlorozotocin, Prednimustine, Estramustine, Procarbazine, Dacarbazine, Hexamethylmelamine, Pentamethylmelamine, Temozolomide, Cisplatin, Carboplatin, Oxaliplatin, Bleomycin, Dactinomycin, Mithramycin, Mitomycin2 C, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Methotrexate, Edatrexate, Trimethoprim, Nolatrexed, Raltitrexed, Hydroxyurea, 5-fluorouracil, Ftorafur, Capecitabine, Furtulon, Eniluracil, ara-C, 5-azacytidine, Gemeitabine, Mercaptopurine, Thioguanine, Pentostatin, antisense DNA, antisense RNA, an antisense DNAIRNA hybrid, a ribozyme, Vincristine, Vinblastine, Paclitaxel, Docetaxel, L-Asparaginase, a kinase inhibitor, Imatinib, Mitotane, Aminoglutethimide, Diethyistilbestrol, Ethinyl estradiol, Tamoxifen, Anastrozole, Testosterone propionate, Fluoxymesterone, Flutamide, Leuprolide, Prednisone, Hydroxyprogesterone caproate, Medroxyprogesterone acetate, Megestrol acetate and Interferon alfa.

34. The method of claim 33, wherein where the cancer therapeutic agent is Gemcitabine.

35. The method of claim 34, wherein where the compound is 3-amino-6-[3-({[(2,4-difluorophenyl)methyl]amino}methyl)phenyl]-N- [(3S)-piperidin-3-yl]pyrazine-2- carboxamide, or a pharmaceutically acceptable salt thereof.

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