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Last Updated: April 24, 2024

Claims for Patent: 7,704,495

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Summary for Patent: 7,704,495

Title:	Process for producing cartilage cells for transplantation
Abstract:	This invention is intended to provide a method to quickly obtain a large amount of normal human chondrocytes or a mass thereof without fear of bacterial or viral infection. Namely, a method of producing human chondrocytes characterized by comprising co-culturing chondrocytes obtained from a cartilage having perichondrium, for example, auricular cartilage together with the perichondrium; and a method of producing human chondrocytes characterized by comprising monolayer or multilayer seeding the cultured cells once or more and culturing to give a chondrocyte mass.
Inventor(s):	Yanaga; Hiroko (Kitakyusyu-shi, Fukuoka, 802-0044, JP)
Assignee:	Yanaga; Hiroko (Fukuoka, JP) Yanaga; Katsu (Fukuoka, JP)
Application Number:	10/552,000
Patent Claims:	1. A method of proliferating human chondrocytes comprising: 1) collecting human cartilage having perichondrium; 2) treating the cartilage having perichondrium with type II collagenase; 3) centrifuging the treated cartilage having perichondrium in step 2) to obtain precipitate; and 4) culturing the precipitate of step 3), wherein the chondrocytes and perichondrium are both in the culture, and wherein no non-human animal feeder cells are present in step 4), and further wherein the cells increase to 1.times.10.sup.6 to 5.times.10.sup.6 cells from 1 cm.sup.2 tissue in primary culture and further increase at least 1000 times in subculture. 2. The method according to claim 1, wherein the cartilage is auricular cartilage. 3. The method according to claim 1, further comprising: seeding the cultured chondrocytes in a monolayer or multilayer at least once; and culturing the chondrocytes until a chondrocyte mass forms. 4. The method according to claim 2, further comprising: seeding the cultured chondrocytes in a monolayer or multilayer at least once; and culturing the chondrocytes until a chondrocyte mass forms. 5. The method according to claim 1, wherein the cells increase to 3.times.10.sup.6 to 5.times.10.sup.6 cells from 1 cm.sup.2 tissue in primary culture.

Details for Patent 7,704,495

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965	⤷ Try a Trial	2023-04-15
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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