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Last Updated: April 23, 2024

Claims for Patent: 7,700,775

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Summary for Patent: 7,700,775

Title:	Compounds and compositions for delivering active agents
Abstract:	Compounds and compositions for the delivery of active agents are provided. Methods of administration and preparation are provided as well.
Inventor(s):	Liao; Jun (Tarrytown, NY), Gschneidner; David (Tarrytown, NY), Weidner; John J. (Tarrytown, NY), Wang; Nai Fang (Tarrytown, NY)
Assignee:	Emisphere Technologies, Inc. (Tarrytown, NY)
Application Number:	10/469,500
Patent Claims:	1. A compound selected from the group consisting of compounds 1-18: ##STR00004## ##STR00005## ##STR00006## and salts thereof. 2. A pharmaceutical composition comprising: (A) a biologically active agent selected from BIBN-4096BS, growth hormones, human growth hormones, recombinant human growth hormones (rhGH), bovine growth hormones, porcine growth hormones, .alpha.-interferon, .beta.-interferon, .gamma.-interferon, interleukin-1, interleukin-2, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor (IGF), IGF-1, heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, calcitonin, salmon calcitonin, eel calcitonin, human calcitonin; erythropoietin (EPO), somatostatin, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, glucocerebrosidase, thrombopoeitin, fligrastim, prostaglandins, cyclosporin, vasopressin, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, vaneomycin, desferrioxamine (DFO), parathyroid hormone (PTH), fragments of PTH, and any combination thereof; and (B) at least one compound selected from ##STR00007## ##STR00008## ##STR00009## and salts thereof. 3. The composition of claim 2, wherein the biologically active agent comprises insulin, BIBN-4096BS, calcitonin, parathyroid hormone, erythropoietin, growth hormones or any combination thereof. 4. The composition of claim 2, wherein the biologically active agent comprises BIBN-4096BS. 5. The composition of claim 2, wherein the biologically active agent comprises insulin. 6. A dosage unit form comprising: (A) the composition of claim 2; and (B) (a) an excipient, (b) a diluent, (c) a disintegrant, (d) a lubricant, (e) a plasticizer, (f) a colorant, (g) a dosing vehicle, or (h) any combination thereof. 7. The dosage unit form of claim 6, wherein the biologically active agent comprises insulin, BIBN-4096BS, calcitonin, parathyroid hormone, erythropoietin, human growth hormones or any combination thereof. 8. The dosage unit form of claim 6, wherein the active agent comprises recombinant BIBN-4096BS. 9. The dosage unit form of claim 6, wherein the active agent comprises insulin. 10. The dosage unit form of claim 6, wherein the dosage unit form comprises a dosing vehicle comprising a tablet, a capsule, a powder, or a liquid. 11. The dosage unit form of claim 6, wherein the dosing vehicle is liquid selected from the group consisting of water, 1,2-propane diol, ethanol, and any combination thereof.

Details for Patent 7,700,775

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	10/28/1982	⤷ Try a Trial	2021-03-01
Eli Lilly And Company	HUMULIN R U-500	insulin human	Injection	018780	12/29/2015	⤷ Try a Trial	2021-03-01
Eli Lilly And Company	HUMULIN R U-100	insulin human	Injection	018780	08/06/1998	⤷ Try a Trial	2021-03-01
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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