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Last Updated: March 28, 2024

Claims for Patent: 7,687,081


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Summary for Patent: 7,687,081
Title:Herbal formulation useful as local anesthetic
Abstract: The invention provides a novel herbal formulation useful as local anesthetic in topical surgical operations, nerve block conduction, extradural and infiltration anesthesia. Formulation(s) comprises of extract(s) of Spilanthus calva and Spilanthus oleraceae with Gymnema sylvestre, Urtica dioica and Piper longum. The formulation can be used as topical application as ointment or spray or cream.
Inventor(s): Palpu; Pushpangadan (Lucknow, IN), Rao; Chandana Venkateswara (Lucknow, IN), Rawat; Ajay Kumar Singh (Lucknow, IN), Ojha; Sanjeev Kumar (Lucknow, IN), Srivastava; Sharad Kumar (Lucknow, IN), Rastogi; Subha (Lucknow, IN), Kumar; Vivek (Lucknow, IN)
Assignee: Council of Scientific and Industrial Research (New Delhi, IN)
Application Number:11/024,008
Patent Claims:1. An herbal local anesthetic formulation comprising extracts of Spilanthes calva (1-3 wt %), Spilanthes oleraceae (1-3wt %), Urtica dioica (2-3 wt %), Piper longum (1-2 wt %) and Gymnema sylvestre (2-3 wt %) in pharmaceutically acceptable dosage form, optionally further comprising an additive.

2. The herbal formulation as claimed in claim 1, wherein the extract of Spilanthes calva is obtained from leaves, roots, flowers, rhizome and/or fruits.

3. The herbal formulation as claimed in claim 1, wherein the extract of Piper longum is obtained from the fruit thereof.

4. The herbal formulation as claimed in claim 1, wherein the extract of Spilanthes leraceae is obtained from leaves, flowers, rhizome and/or unripe fruits.

5. The herbal formulation as claimed in claim 1, wherein the extract of Gymnema sylvestre is obtained from aerial parts thereof.

6. The herbal formulation as claimed in claim 1, wherein the extracts of Spilanthes calva, Spilanthes oleraceae, Piper longum, Urtica dioica and Gymnema sylvestre are mixed with the additive to provide a topical application or intradermal injection form.

7. The herbal formulation as claimed in claim 1, wherein the said formulation has a specific gravity ranging between 0.897-1.127.

8. The herbal formulation as claimed in claim 1, wherein the formulation has a refractive index ranging between 1.1325-1.3642.

9. The herbal formulation as claimed in claim 1, wherein the formulation is a cream or ointment and wherein the additive is selected from the group consisting of poly ethylene glycol bases, hydro emulsifiying bases and bentonite.

10. The herbal formulation as claimed in claim 6, wherein the additive is in the intradermal injection is sterile water.

11. The herbal formulation as claimed in claim 1, wherein additive is selected from the group consisting of tragacanth, pectin, acacia and gelatin.

12. The herbal formulation as claimed in claim 1 wherein said composition is used in the form of topical ointment or spray.

13. The herbal formulation as claimed in claim 1, wherein the formulation at a dose of 400 mg/kg does not show any toxicity in rats.

14. The herbal formulation as claimed in claim 1, wherein the formulation at a dose ranging from 100-200 mg/kg is effective as a local anaesthetic for around 5-7 minutes.

15. A method of effecting local anesthesia for 5-20 minutes comprises administering the herbal formulation as claimed in claim 1 at a dose ranging from 100-200 mg/kg body weight.

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