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Last Updated: March 29, 2024

Claims for Patent: 7,678,767


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Summary for Patent: 7,678,767
Title:Glue compositions for lung volume reduction
Abstract: The present invention relates to methods and compositions for sealing localized regions of damaged lung tissue to reduce overall lung volume. The glue compositions provide a glue featuring an adhering moiety coupled to one or more other moieties including, for example, a cross-linkable moiety and/or one other adhering moiety. The methods and compositions of the invention find use, for example, in treating pulmonary conditions, such as emphysema.
Inventor(s): Gong; Glen (San Francisco, CA), Dieck; Ronald (Palo Alto, CA)
Assignee: PneumRx, Inc. (Mountain View, CA)
Application Number:11/008,087
Patent Claims:1. A biocompatible tissue sealing composition comprising: a cross-linking moiety of a heat stabilized glutaraldehyde; a pharmaceutically acceptable carrier; an albumin as a cross-likable moiety; and an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrypsin, elafin, and a serpin, wherein the albumin is covalently linked to the cross-linking moiety, and wherein the pharmaceutically acceptable carrier is sodium glutamate.

2. A biocompatible tissue sealing composition comprising: a cross-linking moiety of a heat stabilized glutaraldehyde; a pharmaceutically acceptable carrier; an albumin as a cross-linkable moiety; and an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrvpsin, elafin, and a serpin, wherein the albumin is covalently linked to the cross-linking moiety, and wherein the pharmaceutically acceptable carrier is cysteine hydrochloride.

3. A biocompatible tissue sealing composition comprising: a cross-linking moiety of a heat stabilized glutaraldehyde; a pharmaceutically acceptable carrier; an albumin as a cross-linkable moiety; and an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrvpsin, elafin, and a serpin, wherein the albumin is covalently linked to the cross-linking moiety, and wherein the pharmaceutically acceptable carrier is liposomes.

4. A biocompatible tissue sealing composition comprising: a cross-linking moiety of a heat stabilized glutaraldehyde; an albumin as a cross-linkable moiety; an adhering moiety coupled to the cross-linkable moiety, the adhering moiety comprising a member selected from the group consisting of alpha-1-antitrvpsin, elafin, and a serpin; and a pharmaceutically acceptable carrier comprising a member selected from the group consisting of sodium glutamate, cysteine hydrochloride, and a liposome, wherein the albumin is covalently linked to the cross-linking moiety.

5. The biocompatible tissue sealing composition as recited in claim 4, wherein said albumin is mammalian albumin.

6. The biocompatible tissue sealing composition as recited in claim 4, wherein said albumin is porcine albumin.

7. The biocompatible tissue sealing composition as recited in claim 4, wherein said albumin is human albumin.

8. The biocompatible tissue sealing composition as recited in claim 4, wherein said albumin is bovine albumin.

9. The biocompatible tissue sealing composition as recited in claim 4, wherein said albumin is recombinant albumin.

Details for Patent 7,678,767

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 10/21/1942 ⤷  Try a Trial 2024-06-16
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 03/03/1954 ⤷  Try a Trial 2024-06-16
Csl Behring Ag ALBURX albumin (human) Injection 102366 07/23/1976 ⤷  Try a Trial 2024-06-16
Grifols Biologicals Llc ALBUTEIN albumin (human) Injection 102478 08/15/1978 ⤷  Try a Trial 2024-06-16
Instituto Grifols, S.a. HUMAN ALBUMIN GRIFOLS albumin (human) Injection 103352 02/17/1995 ⤷  Try a Trial 2024-06-16
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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