You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 7,667,091


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 7,667,091
Title:Method of encoding information in nucleic acids of a genetically engineered organism
Abstract: The present invention provides a method of producing a genetically engineered transgenic organism, by (a) incorporating into the organism a functional DNA sequence that confers a trait on an organism and (b) incorporating into the organism a non-functional DNA sequence, wherein the non-functional DNA sequence encodes an information message using a predefined coding scheme, wherein the information message provides information about the functional DNA sequence, and the predefined coding scheme can be used to map a plurality of information messages into a plurality of non-functional DNA sequences and additionally, the functional and the non-functional DNA sequence are incorporated into the same chromosome of the organism.
Inventor(s): Gleba; Yuri (Halle/Saale, DE), Klimyuk; Victor (Halle/Saale, DE)
Assignee: Icon Genetics GmbH (Munich, DE)
Application Number:10/471,960
Patent Claims:1. A method of producing a genetically engineered transgenic non-human organism comprising: (a) incorporating into a non-human organism a functional DNA sequence that confers a trait on said organism; and (b) incorporating into said organism a non-functional DNA sequence, wherein said non-functional DNA has no function in the organism other than that of providing information about said functional DNA, further wherein (i) said non-functional DNA sequence encodes an information message using a predefined coding scheme; and (ii) said information message provides information about said functional DNA sequence, and wherein said functional DNA sequence of (a) above and said non-functional DNA sequence of (b) above are incorporated into the same chromosome of said organism, thereby producing a genetically engineered transgenic non-human organism.

2. The method according to claim 1, wherein said functional DNA sequence is incorporated into said organism prior to said non-functional DNA sequence.

3. The method according to claim 1, wherein said non-functional DNA sequence is incorporated into said organism prior to said functional DNA sequence.

4. The method according to claim 1, wherein said non-functional DNA sequence and said functional DNA sequence are incorporated into said organism simultaneously.

5. The method according to claim 1, wherein said non-functional DNA sequence and said functional DNA sequence are located sufficiently close on said chromosome to prevent separation by recombination.

6. The method according to claim 1, wherein said non-functional DNA sequence is an intron or encodes an intein.

7. The method according to claim 6, wherein the intron or intein-encoding sequence is placed within the related functional DNA sequence.

8. The method according to claim 7, wherein the intron or intein-encoding sequence is placed within a conserved portion of the related functional DNA sequence.

9. The method according to claim 1, wherein said non-functional DNA sequence, optionally in conjunction with a spacer DNA sequence between said non-functional DNA sequence and said functional DNA sequence, is chosen such that it is not able to form secondary structures and/or such that it is free of recombination or mutation hot spots.

10. The method according to claim 1, wherein said mapping is from DNA portions to alphanumeric characters.

11. The method according to claim 1, wherein said predefined coding scheme translates DNA triplets to alphanumeric characters.

12. The method according to claim 1, wherein said non-functional DNA sequence comprises at least one pre-defined recognition sequence that allows for identification and/or analysis of said non-functional DNA sequence.

13. The method according to claim 12, wherein said non-functional DNA sequence is flanked at least on one side by the recognition sequence.

14. The method according to claim 12, wherein said pre defined recognition sequence comprises joint and/or separate recognition of multiple non-functional DNA sequences in the organism.

15. The method according to claim 12, wherein said pre defined recognition sequences are placed such to allow PCR amplification of said functional DNA sequence or portions thereof using primers complementary to said pre-defined recognition sequences.

16. The method according to claim 12, wherein said pre defined recognition sequence comprises joint and/or separate recognition of multiple non-functional DNA sequences in the organism.

17. The method according to claim 1, wherein the functional DNA sequence is flanked on both sides by portions of said non-functional DNA sequence.

18. The method according to claim 1, wherein said non-functional DNA sequence contains an additional DNA sequence encoding an expressible polypeptide for quick detection.

19. The method according to claim 1, wherein the information message comprises a trademark, a reference to a database, a date, a place, the name of a producer or an owner, or an indication of the presence and/or position of said functional DNA sequence, or any combination thereof.

20. The method according to claim 1, wherein said non-functional DNA sequence does not adversely affect the performance of said functional DNA sequence in said genetically engineered organism.

21. The method according to claim 1, wherein said incorporation into said organism of said non-functional DNA sequence does not adversely affect the genetic stability of said non-functional and/or said functional DNA sequence and/or the incorporation of said non-functional and said functional DNA sequence into the same chromosome of said organism.

22. The method according to claim 1, wherein the organism is a plant.

23. The method according to claim 1, wherein the organism is an animal.

24. The method according to claim 1, wherein said predefined coding scheme can be used to map a plurality of information messages to a plurality of said non-functional DNA sequences.

25. The method according to claim 1, wherein using said predefined coding scheme, said information message can be non-uniquely mapped to multiple non-functional DNA sequences and said nonfunctional DNA sequence can be uniquely mapped to said information message.

Details for Patent 7,667,091

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2021-03-29
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2021-03-29
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2021-03-29
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.