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Last Updated: March 29, 2024

Claims for Patent: 7,666,616


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Summary for Patent: 7,666,616
Title:Nucleic acid sequences encoding luciferase for expression in filamentous fungi
Abstract: The present invention relates to genetic reporters. Specifically, the present invention is directed to a modified gene encoding a luciferase for high level expression in an organism with a bias for cytosine (C) or guanine (G) in the third position of the codon.
Inventor(s): Dunlap; Jay C. (Thetford, VT), Loros; Jennifer (Thetford, VT), Mehra; Arun (Hanover, NH), Gooch; Van D. (Morris, MN)
Assignee: Trustees of Dartmouth College (Hanover, NH) Regents of the University of Minnesota (Minneapolis, MN)
Application Number:11/576,168
Patent Claims:1. An isolated nucleic acid molecule comprising the polynucleotide sequence of SEQ ID NO: 1 and encoding a Photinus luciferase of SEQ ID NO:3 for expression in an organism with a bias for cytosine (C) or guanine (G) in the third position of the codon, wherein the nucleic acid sequence has a G and C content of at least 50% and an intron comprising SEQ ID NO:5.

2. A vector comprising the nucleic acid molecule of claim 1.

3. An isolated host cell containing the vector of claim 2.

4. A method for enhancing the level of a luciferase enzyme in an organism with a bias for C or G in the third position of the codon comprising introducing into an organism with a bias for C or G in the third position of the codon a nucleic acid molecule of claim 1, thereby enhancing the level of luciferase enzyme produced in the organism.

5. A kit for expressing a luciferase enzyme in an organism with a bias for C or G in the third position of the codon comprising the nucleic acid molecule of claim 1.

6. An isolated nucleic acid molecule comprising SEQ ID NO:1.

7. The nucleic acid molecule of claim 6, further comprising an intron of SEQ ID NO:5.

Details for Patent 7,666,616

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2024-09-30
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2024-09-30
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2024-09-30
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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