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Last Updated: March 28, 2024

Claims for Patent: 7,655,227


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Summary for Patent: 7,655,227
Title:Agents for ameliorating low vasopressin level
Abstract: The present invention provides an agent for ameliorating low vasopressin level, which comprises, as an active ingredient, a substance capable of inhibiting the binding between parathyroid hormone-related peptide (PTHrP) and a receptor thereof; and an agent for ameliorating a symptom caused by a decrease in vasopressin level, which comprises, as an active ingredient, a substance capable of inhibiting the binding between parathyroid hormone-related peptide (PTHrP) and a receptor thereof.
Inventor(s): Ogata; Etsuro (Tokyo, JP), Onuma; Etsuro (Shizuoka, JP), Tsunenari; Toshiaki (Shizuoka, JP), Saito; Hidemi (Shizuoka, JP), Azuma; Yumiko (Shizuoka, JP)
Assignee: Chugai Seiyaku Kabushiki Kaisha (Tokyo, JP)
Application Number:10/019,501
Patent Claims:1. A method of treating hyperosmolarity caused by a decrease in vasopressin level in blood comprising administering to a patient at least one humanized anti-parathyroid hormone related protein 1-34 (anti-PTHrP (1-34)) antibody, or a binding fragment thereof that binds to SEQ ID NO: 75 in an amount sufficient to inhibit the decrease in vasopressin level in the blood of the patient, wherein said at least one humanized anti-parathyroid hormone related protein 1-34 (anti-PTHrP (1-34)) antibody, or binding fragment thereof comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 56 and a light chain variable region comprising the amino acid sequence selected from the group consisting of SEQ ID NO: 47, 48, 49, 50, 51, 52, 53, 54 and 55.

2. The method according to claim 1, wherein the decrease in vasopressin level results from cancer.

3. The method according to claim 1, wherein the binding fragment is Fab, scFv, F(ab').sub.2 or Fv.

4. The method according to claim 1, wherein the antibody is a monoclonal antibody.

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