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Last Updated: March 29, 2024

Claims for Patent: 7,638,488


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Summary for Patent: 7,638,488
Title:Use of alpha-glucosidase inhibitors to treat alphavirus infections
Abstract: The present invention provides methods for treating a flavivirus infection, including hepatitis C virus (HCV) infection, in an individual suffering from a flavivirus infection. In some embodiments, the methods involve administering to an individual in need thereof an effective amount of an agent that inhibits enzymatic activity of a membrane-bound .alpha.-glucosidase inhibitor. In other embodiments, the methods involve administering to an individual in need thereof effective amounts of an .alpha.-glucosidase inhibitor and at least one additional therapeutic agent.
Inventor(s): Blatt; Lawrence M. (San Francisco, CA), Tan; Hua (Daly City, CA), Seiwert; Scott (Pacifica, CA)
Assignee: Intermune, Inc. (Brisbane, CA)
Application Number:11/370,535
Patent Claims:1. A method of treating a flavivirus infection in an individual, the method comprising administering to an individual in need thereof an effective amount of an agent that inhibits enzymatic activity of a membrane-bound .alpha.-glucosidase, wherein the agent is not an imino sugar.

2. The method of claim 1, wherein the agent inhibits the p7 protein of hepatitis C virus.

3. The method of claim 1, wherein the agent is acarbose or castanospermine.

4. A method of treating a flavivirus infection in an individual, the method comprising administering to an individual in need thereof effective amounts of an .alpha.-glucosidase inhibitor and at least one additional therapeutic agent, wherein the .alpha.-glucosidase inhibitor is not an imino sugar.

5. The method of claim 4, wherein the at least one additional therapeutic agent comprises an interferon-.alpha. (IFN-.alpha.).

6. The method of claim 5, wherein the IFN-.alpha. is interferon alfacon-1.

7. The method of claim 6, wherein the IFN-.alpha. is pegylated.

8. The method of claim 7, wherein the pegylated IFN-.alpha. is selected from peginterferon alfa-2a, peginterferon alfa-2b, and monoPEG (30 kD, linear)-ylated consensus IFN-.alpha..

9. The method of claim 6, wherein the IFN-.alpha. is hyperglycosylated.

10. The method of claim 4, wherein the at least one additional therapeutic agent comprises an interferon-.gamma.(IFN-.gamma.).

11. The method of claim 10, wherein the IFN-.gamma. is interferon .gamma.-1b.

12. The method of claim 11, wherein the IFN-.gamma. is pegylated.

13. The method of claim 11, wherein the IFN-.gamma. is hyperglycosylated.

14. The method of claim 4, wherein the at least one additional therapeutic agent comprises an HCV NS3 protease inhibitor.

15. The method of claim 4, wherein the at least one additional therapeutic agent comprises an HCV NS5B RNA-dependent RNA polymerase inhibitor.

16. The method of claim 4, wherein the at least one additional therapeutic agent comprises a nucleoside analog.

17. The method of claim 16, wherein the nucleoside analog is selected from viramidine, ribavirin, and levovirin.

18. The method of claim 4, wherein the .alpha.-glucosidase inhibitor is acarbose or castanospermine.

19. The method of claim 1 or 4, wherein the .alpha.-glucosidase inhibitor is administered at a dosage selected from the group consisting of: about 10 mg--about 30 mg per day; about 30 mg--about 60 mg per day; about 10 mg three times daily; about 15 mg three times daily; and about 20 mg three times daily.

20. The method of any one of claims 1, 2, 3, 4-17 or 18, wherein the individual is a human.

Details for Patent 7,638,488

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Kadmon Pharmaceuticals Llc INFERGEN interferon alfacon-1 Injection 103663 10/06/1997 ⤷  Try a Trial 2025-03-08
Horizon Therapeutics Ireland Dac ACTIMMUNE interferon gamma-1b Injection 103836 02/25/1999 ⤷  Try a Trial 2025-03-08
Merck Sharp & Dohme Corp. PEGINTRON peginterferon alfa-2b Injection 103949 01/19/2001 ⤷  Try a Trial 2025-03-08
Merck Sharp & Dohme Corp. SYLATRON peginterferon alfa-2b For Injection 103949 03/29/2011 ⤷  Try a Trial 2025-03-08
Zr Pharma& Gmbh PEGASYS peginterferon alfa-2a Injection 103964 10/16/2002 ⤷  Try a Trial 2025-03-08
Zr Pharma& Gmbh PEGASYS peginterferon alfa-2a Injection 103964 01/07/2004 ⤷  Try a Trial 2025-03-08
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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