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Last Updated: April 16, 2024

Claims for Patent: 7,638,138

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Summary for Patent: 7,638,138

Title:	Compositions for nasal administration of pharmaceuticals
Abstract:	Compositions for nasal administration, which comprise a pharmaceutical, a physiologically active peptide, or a peptide-related compound, and as the carrier thereof, crystalline cellulose with a specific particle diameter and/or partially pregelatinized starch are provided. Such compositions improve the in vivo absorption efficiency of pharmaceuticals.
Inventor(s):	Oki; Toshikazu (Yokohama, JP), Hanafusa; Takashi (Kobe, JP), Haruta; Shunji (Kagoshima, JP)
Assignee:	Translational Research, Ltd. (Kagoshima, JP)
Application Number:	10/545,764
Patent Claims:	1. A granular composition for nasal administration, which comprises: a) a powdered pharmaceutical, and b) as a carrier thereof, a substantially water-insoluble crystalline cellulose powder, wherein the pharmaceutical is selected from growth hormone, calcitonin, glucagon, glucagon-like peptide-1, interferon, interleukin, erythropoietin, luteinizing hormone-releasing hormone, somatostatin, vasopressin, oxytocin, enkephalin, adrenocorticotropic hormone, growth hormone-releasing hormone, granulocyte colony formation-stimulating factor, parathyroid hormone, thyroid-stimulating hormone-releasing hormone, angiotensin, prolactin, luteinizing hormone, gastric inhibitory polypeptide (GIP), C-peptide, cyclosporine, and FK-506, and parathyroid hormone (1-34); wherein the crystalline cellulose powder has a sieving particle diameter distribution of: 10 wt % or fewer particles with a diameter smaller than 25 .mu.m; 20 to 60 wt % particles with a diameter of 25 to 38 .mu.m; 20 to 60 wt % particles with a diameter greater than 38 .mu.m and smaller than or equal to 53 .mu.m; and the remaining particles having a diameter greater than 53; and wherein the crystalline cellulose powder has a bulk density of 0.22 to 0.40 g/cm.sup.3. 2. The composition of claim 1, wherein the pharmaceutical is a human growth hormone. 3. The composition of claim 1, wherein the pharmaceutical is selected from glucagon, calcitonin, parathyroid hormone, or parathyroid hormone (1-34). 4. The composition of claim 1, wherein the pharmaceutical is parathyroid hormone. 5. The composition of claim 1, wherein the pharmaceutical is parathyroid hormone (1-34). 6. The composition of claim 1, wherein the pharmaceutical is luteinizing hormone-releasing hormone. 7. The composition of claim 1, wherein the crystalline cellulose powder has an average polymerization degree of 20 to 250. 8. The composition of claim 1, wherein the crystalline cellulose powder has a bulk density of about 0.22 g/cm.sup.3.

Details for Patent 7,638,138

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2039-03-29
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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