Claims for Patent: 7,582,301
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Summary for Patent: 7,582,301
Title: | Long-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides |
Abstract: | Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component. |
Inventor(s): | Bridon; Dominique P. (Outremont, CA), Dufresne; Robert P. (Wellseley, MA), Boudjellab; Nissab (Dorval, CA), Robitaille; Martin (Terrasse-Vaudreuil, CA), Milner; Peter G. (Los Altos Hills, CA) |
Assignee: | Conjuchem Biotechnologies, Inc. (Montreal, Quebec, CA) |
Application Number: | 09/623,533 |
Patent Claims: | 1. An antifusogenic peptide-albumin conjugate comprising: an anti-fusogenic peptide comprising a maleimide containing group and an amino acid sequence, wherein said sequence is
selected from the group consisting of SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 117, SEQ ID NO: 118, SEQ ID NO: 119, SEQ ID NO: 534, SEQ ID NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO: 539, SEQ ID NO: 540,
and SEQ ID NO: 541, wherein said sequence exhibits an anti-viral and antifusogenic activity against human immunodeficiency virus (HIV) and said peptide is covalently bonded to cysteine 34 of albumin through said maleimide containing group to form said
peptide-albumin conjugate wherein the ratio of peptide to albumin in said conjugate is 1:1, and wherein said maleimide containing group is attached to said peptide without a linker or via a (2-amino)ethoxy acetic acid (AEA) or a [2-(2-amino) ethoxy]
acetic acid (AEEA) linker.
2. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO:1. 3. An anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 117, SEQ ID NO: 118, SEQ ID NO: 119, SEQ ID NO: 534, SEQ ID NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO: 539, SEQ ID NO: 540, and SEQ ID NO: 541. 4. A composition for use in the treatment of acquired immune deficiency syndrome (AIDS) comprising, in a physiologically acceptable medium, an anti-fusogenic peptide-albumin conjugate comprising an anti-fusogenic peptide comprising a maleimide containing group and an amino acid sequence wherein said sequence is selected from the group consisting of SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 117, SEQ ID NO: 118, SEQ ID NO: 119, SEQ ID NO: 534, SEQ ID NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO: 539, SEQ ID NO: 540, and SEQ ID NO: 541, wherein said sequence inhibits an anti-viral and anti-fusogenic activity against human immunodeficiency virus (HIV) and said peptide is covalently bonded to cysteine 34 of albumin through said maleimide containing group to form said anti-viral peptide-albumin conjugate, wherein the ratio of peptide to albumin in said conjugate is 1:1, wherein said maleimide containing group is attached to said peptide without a linker or via a (2-amino)ethoxy acetic acid (AEA) or a [2-(2-amino) ethoxy] acetic acid (AEEA) linker. 5. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO:1. 6. The composition of claim 4, wherein said amino acid sequence is selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 117, SEQ ID NO: 118, SEQ ID NO: 119, SEQ ID NO: 534, SEQ ID NO: 535, SEQ ID NO: 536, SEQ ID NO: 537, SEQ ID NO: 538, SEQ ID NO: 539, SEQ ID NO: 540, and SEQ ID NO: 541. 7. A composition comprising the anti-fusogenic peptide-albumin conjugate of claim 1 in a physiologically acceptable medium. 8. The composition of claim 7, wherein said amino acid sequence is SEQ ID NO:1. 9. The composition of claim 7, wherein said amino acid sequence is selected from the group consisting of SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO: 117, SEQ ID NO:118, SEQ ID NO:119, SEQ ID NO:534; SEQ ID NO:535, SEQ ID NO:536; SEQ ID NO:537, SEQ ID NO:538, SEQ ID NO:539, SEQ ID NO:540, and SEQ ID NO: 541. 10. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said albumin is serum albumin. 11. The anti-fusogenic peptide-albumin conjugate of claim 10, wherein said albumin is human serum albumin. 12. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO:3. 13. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO:4. 14. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 5. 15. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 117. 16. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 118. 17. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 119. 18. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 534. 19. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 535. 20. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 536. 21. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 537. 22. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 538. 23. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 539. 24. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 540. 25. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein said amino acid sequence is SEQ ID NO: 541. 26. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 3. 27. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 4. 28. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 5. 29. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 117. 30. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 118. 31. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 119. 32. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 534. 33. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 535. 34. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 536. 35. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 537. 36. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 538. 37. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 539. 38. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 540. 39. The composition of claim 4, wherein said amino acid sequence is SEQ ID NO: 541. 40. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein the maleimide containing group is maleimidopropionic acid (MPA) or gamma-maleimide-butyralamide (GMBA). 41. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein the maleimide containing group is attached to the peptide via the (2-amino)ethoxy acetic acid (AEA) or the [2-(2-amino) ethoxy] acetic acid (AEEA) linker. 42. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein the maleimide containing group is attached to the peptide without a linking group. 43. The composition of claim 4, wherein the maleimide containing group is maleimidopropionic acid (MPA) or gamma-maleimide-butyralamide (GMBA). 44. The composition of claim 4, wherein the maleimide containing group is attached to the peptide via the (2-amino)ethoxy acetic acid (AEA) or the [2-(2-amino) ethoxy] acetic acid (AEEA) linker. 45. The composition of claim 4, wherein the maleimide containing group is attached to the peptide without a linking group. 46. The anti-fusogenic peptide-albumin conjugate of claim 1, wherein the peptide exhibits anti-viral and anti-fusogenic activity by modulation of a viral-cellular fusion process involving a coiled-coil peptide structure. 47. The composition of claim 4, wherein the peptide exhibits anti-viral and anti-fusogenic activity by modulation of a viral-cellular fusion process involving a coiled-coil peptide structure. |
Details for Patent 7,582,301
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Grifols Therapeutics Llc | ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 | albumin (human) | For Injection | 101138 | 10/21/1942 | ⤷ Try a Trial | 2040-01-28 |
Baxalta Us Inc. | BUMINATE, FLEXBUMIN | albumin (human) | Injection | 101452 | 03/03/1954 | ⤷ Try a Trial | 2040-01-28 |
Csl Behring Ag | ALBURX | albumin (human) | Injection | 102366 | 07/23/1976 | ⤷ Try a Trial | 2040-01-28 |
Grifols Biologicals Llc | ALBUTEIN | albumin (human) | Injection | 102478 | 08/15/1978 | ⤷ Try a Trial | 2040-01-28 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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