Claims for Patent: 7,563,790

Summary for Patent: 7,563,790

Title:	Pyridazine derivatives
Abstract:	Pyridazine derivatives of the formula (I) act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumors, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS. ##STR00001##
Inventor(s):	Eggenweiler; Hans-Michael (Darmstadt, DE), Wolf; Michael (Darmstadt, DE)
Assignee:	Merck Patent GmbH (Darmstadt, DE)
Application Number:	11/497,241
Patent Claims:	1. A method for treating or combating an allergic disease, asthma, chronic bronchitis, atopic dermatitis, psoriasis, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus, ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, sepsis, atherosclerosis or AIDS; comprising administering to a patient in need thereof an effective amount of a compound of formula I ##STR00029## in which R.sup.1 and R.sup.2 are each, independently of one another, H, OH, OR.sup.8,--SR.sup.8,--SOR.sup.8,--SO.sub.2R.sup.8 or Hal, R.sup.1 and R.sup.2 together are alternatively --OCH.sub.2O-- or --OCH.sub.2CH.sub.2O--, R.sup.3 is H, A''R.sup.9, COA''R.sup.9,COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)(A'''R.sup.9),NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R.sup.9), NCOA''R.sup.9 or NCOOA''R.sup.9, R.sup.4 is H, A''R.sup.9, COA''R.sup.9, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9 or CON(A''R.sup.9)(A'''R.sup.9), B is an aromatic isocyclic or heterocyclic radical, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by R.sup.5, R.sup.6 and/or R.sup.7, X is alkylene having 1-10 carbon atoms or alkenylene having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2NH or NA''R.sup.9, 1-7 H atoms may be replaced by F and/or Cl, and/or 1 or 2 H atoms may be replaced by R.sup.11 and/or R.sup.12, R.sup.5, R.sup.6 and R.sup.7 are each, independently of one another, H, A''R.sup.9, OH, OA''R.sup.9, NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R.sup.9), NHCOA''R.sup.9, NHCOOA''R.sup.9, NHCONH.sub.2, NHCONHA''R.sup.9, NHCON(A''R.sup.9)(A'''R.sup.9), Hal, COOH, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)('''R.sup.9), ##STR00030## R.sup.8 is A, cycloalkyl having 3-7 carbon atoms or alkylenecycloalkyl having 4-8 carbon atoms, R.sup.9 is H, COOH, COOA, CONH.sub.2, CONHA, CONAA', NH.sub.2, NHA, NAA', NCOA, NCOOA, OH, OA, (CH.sub.2).sub.n-aryl or (CH.sub.2).sub.nHet, R.sup.10 is alkyl having 1-10 carbon atoms, cycloalkyl having 3-7 carbon atoms, alkylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH, NMe, NEt and/or by --CH.dbd.CH-- groups, 1-7 H atoms may be replaced by F and/or Cl, and/or 1 H atom may be replaced by R.sup.9, R.sup.11 is H, A, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)(A'''R.sup.9), NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R.sup.9), NCOA''R.sup.9, NCOOA''R.sup.9, OH or OA''R.sup.9, R.sup.12 is H, A, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9 or CON(A''R.sup.9)(A'''R.sup.9), Y is alkylene having 1-10 carbon atoms or alkenylene having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH or NR.sup.10 and/or 1-7 H atoms may be replaced by F and/or Cl, A and A' are each, independently of one another, alkyl having 1-10 carbon atoms or alkenyl having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH or NR.sup.10 and/or 1-7 H atoms may be replaced by F and/or Cl, or aryl or Het, A and A' together are alternatively an alkylene chain having 2-7 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH, NR.sup.10, NCOR.sup.10 or NCOOR.sup.10, A'' and A''' are each, independently of one another, absent, alkylene having 1-10 carbon atoms, alkenylene having 2-8 carbon atoms or cycloalkylene having 3-7 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH or NR.sup.10 and/or 1-7 H atoms may be replaced by F and/or Cl, A'' and A''' together are alternatively an alkylene chain having 2-7 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH, NR.sup.10, NCOR.sup.10 or NCOOR.sup.10, aryl is phenyl, naphthyl, fluorenyl or biphenyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, R.sup.14, OR.sup.13, N(R.sup.13).sub.2, NO.sub.2, CN, COOR.sup.13, CON(R.sup.13).sub.2, NR.sup.13COR.sup.13, NR.sup.13CON(R.sup.13).sub.2, NR.sup.13SO.sub.2A, COR.sup.13, SO.sub.2N(R.sup.13).sub.2 or S(O).sub.mR.sup.14, R.sup.13 is H or alkyl having 1-6 carbon atoms, R.sup.14 is alkyl having 1-6 carbon atoms, Het is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 or 2 N, O and/or S atoms, which may be unsubstituted or monosubstituted or disubstituted by oxo group, Hal, R.sup.14, OR.sup.13, N(R.sup.13).sub.2, NO.sub.2, CN, COOR.sup.13, CON(R.sup.13).sub.2, NR.sup.13COR.sup.13, NR.sup.13CON(R.sup.13).sub.2, NR.sup.13SO.sub.2R.sup.14, COR.sup.13, SO.sub.2NR.sup.13 and/or S(O).sub.mR.sup.14, Hal is F, Cl, Br or I, m is 0, 1 or 2, and n is 0, 1, 2, 3 or 4, or a pharmaceutically acceptable salt, or a stereoisomer thereof. 2. A method according to claim 1 wherein a compound of formula I or a pharmaceutically acceptable salt thereof is administered. 3. A method according to claim 2, in which R.sup.1 and R.sup.2 are each, independently of one another, H, methoxy, ethoxy, benzyloxy, propoxy, isopropoxy, difluoromethoxy, F, Cl, cyclopentyloxy, cyclohexyloxy or cycloheptyloxy. 4. A method according to claim 2, in which R.sup.1 and R.sup.2 are each, independently of one another, methoxy, ethoxy, propoxy, isopropoxy, cyclopentyloxy or F. 5. A method according to claim 2, in which R.sup.1 is 4-methoxy, and R.sup.2 is 3-ethoxy. 6. A method according to claim 2, in which R.sup.1 is H. 7. A method according to claim 2, in which R.sup.3 is H, COO(CH.sub.2).sub.n-aryl, COA''H, COOA''H, A''NAA', A''-aryl or A''Het. 8. A method according to claim 2, in which X is methylene, ethylene, propylene or butylene. 9. A method according to claim 2, in which B is phenyl, pyridyl, pyridyl N-oxide, thienyl, furyl, pyrrolyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, isoxazolinyl, oxazolinyl, thiazolinyl, pyrazolinyl, imidazolinyl, naphthyl, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl or quinoxalinyl, each of which is unsubstituted or may be monosubstituted, disubstituted or trisubstituted by OH, OA, NH.sub.2, NAA', O-alkylene-NAA' or O-alkylene-OH. 10. A method according to claim 2, in which B is phenyl which is unsubstituted or monosubstituted by OR.sup.13, N(R.sup.13).sub.2, O-alkylene-N(R.sup.13).sub.2 or O-alkylene-OH, or unsubstituted pyridyl. 11. A method according to claim 2, in which R.sup.1 and R.sup.2 are each, independently of one another, H, methoxy, ethoxy, benzyloxy, propoxy, isopropoxy, difluoromethoxy, F, Cl, cyclopentyloxy, cyclohexyloxy or cycloheptyloxy, R.sup.1 and R.sup.2 together are alternatively --OCH.sub.2O-- or --OCH.sub.2CH.sub.2--O--, R.sup.3 is H, A''R.sup.9, COA''R.sup.9, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)(A'''R.sup.9), NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R), NCOA''R.sup.9 or NCOOA''R.sup.9, R.sup.4 is H, X is methylene, ethylene, propylene or butylene, A'' and A''' are each, independently of one another, absent or alkylene having 1, 2, 3 or 4 carbon atoms, and R.sup.9 is H, (CH.sub.2).sub.n-aryl or (CH.sub.2).sub.nHet. 12. A method according to claim 2, in which R.sup.1 and R.sup.2 are each, independently of one another, H, methoxy, ethoxy, benzyloxy, propoxy, isopropoxy, difluoromethoxy, F, Cl, cyclopentyloxy, cyclohexyloxy or cycloheptyloxy, R.sup.1 and R.sup.2 together are alternatively --OCH.sub.2O-- or --OCH.sub.2CH.sub.2--O--, R.sup.3 is H, A''R.sup.9, COA''R.sup.9, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)(A'''R.sup.9), NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R.sup.9), NCOA''R.sup.9 or NCOOA''R.sup.9, R.sup.4 is H, X is methylene, ethylene, propylene or butylene, A'' and A''' are each, independently of one another, absent or alkylene having 1, 2, 3 or 4 carbon atoms, R.sup.9 is H, (CH.sub.2).sub.n-aryl or (CH.sub.2).sub.nHet, aryl is phenyl, naphthyl, fluorenyl or biphenyl, each of which is unsubstituted or monosubstituted by OR.sup.13, R.sup.13 is H or alkyl having 1-6 carbon atoms, Het is pyridyl, pyridyl N-oxide, thienyl, furyl, pyrrolyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, isoxazolinyl, oxazolinyl, thiazolinyl, pyrazolinyl, imidazolinyl, naphthyl, quinolinyl, isoquinolinyl, cinnolinyl, phthalazinyl, quinazolinyl or quinoxalinyl, and B is phenyl which is unsubstituted or monosubstituted by OR.sup.13, N(R.sup.13).sub.2, O-alkylene-N(R.sup.13).sub.2 or O-alkylene-OH, or unsubstituted pyridyl. 13. A method according to claim 2, in which R.sup.1 and R.sup.2 are each, independently of one another, methoxy, ethoxy, propoxy or isopropoxy, R.sup.3 is H, fluorenylmethyloxycarbonyl, acetyl, tert-butyloxycarbonyl, benzyloxycarbonyl, N,N-dimethylaminoethyl, benzyl or pyridylmethyl, R.sup.4 is H, X is methylene, ethylene, propylene or butylene, R.sup.13 is H or alkyl having 1-6 carbon atoms, Het is pyridyl, and B is phenyl which is unsubstituted or monosubstituted by OR.sup.13, N(R.sup.13).sub.2, O-alkylene-N(R.sup.13).sub.2 or O-alkylene-OH, or unsubstituted pyridyl. 14. A method according to claim 2, wherein the compound of formula I is a) benzyl {1-(1S)-(4-tert-butoxybenzyl)-2-[3-(3-ethoxy-4-methoxyphenyl)-5- ,6-dihydro-4H-pyridazin-1-yl]-2-oxoethyl}carbamate, b) benzyl {2-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(1S)-(4- -hydroxybenzyl)-2-oxoethyl}carbamate, c) 2-(2S)-amino-1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-y- l]-3-[4-(2-hydroxyethoxy)phenyl]propan-1-one, d) 3-[4-(2-dimethylaminoethoxy)phenyl]-2-(2S)-(2-dimethylaminoethylamino)-1-- [3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]propan-1-one, e) 2-(2S)-amino-3-[4-(2-dimethylaminoethoxy)phenyl]-1-[3-(3-ethoxy-4-meth- oxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]propan-1-one, f) 9H-fluoren-9-ylmethyl{1-(1S)-(4-tert-butoxybenzyl)-2-[3-(3-ethoxy-4-metho- xyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-2-oxoethyl}carbamate, g) 2-(2S)-amino-3-(4-tert-butoxyphenyl)-1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-- dihydro-4H-pyridazin-1-yl]propan-1-one, h) 2-(2S)-amino-1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-y- l]-3-(4-hydroxyphenyl)propan-1-one, i) 2-(2S)-benzylamino-1-[3-(3-ethoxy-4-methoxyphenyl) -5,6-dihydro-4H-pyridazin-1-yl]-3-(4-hydroxyphenyl)propan-1-one, j) 1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-3-(4-hydro- xyphenyl)-2-(2S)-[(pyridin-4-ylmethyl)amino]propan-1-one, k) tert-butyl {1-(1R)-(4-methoxybenzyl)-2-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-- pyridazin-1-yl]-2-oxoethyl}carbamate, l) tert-butyl {1-(1S)-(4-methoxybenzyl)-2-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-- pyridazin-1-yl]-2-oxoethyl}carbamate, m) N-{1-(1S)-(4-tert-butoxybenzyl)-2-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihyd- ro-4H-pyridazin-1-yl]-2-oxoethyl}acetamide, n) N-[2-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-1-(1S)-- (4-hydroxybenzyl)-2-oxoethyl]acetamide, o) tert-butyl {2-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-2-oxo-1-(- 1R)-(pyridin-3-ylmethyl)ethyl}carbamate, p) 2-(2R)-amino-1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-y- l]-3-pyridin-3-ylpropan-1-one, q) tert-butyl {2-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-yl]-2-oxo-1-(- 1R)-(pyridin-4-ylmethyl)ethyl}carbamate, or r) 2-(2R)-amino-1-[3-(3-ethoxy-4-methoxyphenyl)-5,6-dihydro-4H-pyridazin-1-y- l]-3-pyridin-4-ylpropan-1-one, or a pharmaceutically acceptable salt thereof. 15. A method according to claim 2, which is for treating or combating an allergic disease, asthma, chronic bronchitis, atopic dermatitis, psoriasis, rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus, ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, sepsis, atherosclerosis or AIDS. 16. A pharmaceutical composition comprising a compound of formula I ##STR00031## in which R.sup.1 and R.sup.2 are each, independently of one another, H, OH, OR.sup.8, --SR.sup.8, --SOR.sup.8, --SO.sub.2R.sup.8 or Hal, R.sup.1 and R.sup.2 together are alternatively --OCH.sub.2O-- or --OCH.sub.2CH.sub.2O--, R.sup.3 is H, A''R.sup.9, COA''R.sup.9, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)(A'''R.sup.9), NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R.sup.9), NCOA''R.sup.9 or NCOOA''R.sup.9, R.sup.4 is H, A''R.sup.9, COA''R.sup.9, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9 or CON(A''R.sup.9)(A'''R.sup.9), B is an aromatic isocyclic or heterocyclic radical, which may be unsubstituted or monosubstituted, disubstituted or trisubstituted by R.sup.5, R.sup.6 and/or R.sup.7, X is alkylene having 1-10 carbon atoms or alkenylene having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH or NA''R.sup.9, 1-7 H atoms may be replaced by F and/or Cl, and/or 1 or 2 H atoms may be replaced by R.sup.11 and/or R.sup.12, R.sup.5, R.sup.6 and R.sup.7 are each, independently of one another, H, A''R.sup.9, OH, OA''R.sup.9, NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R.sup.9), NHCOA''R.sup.9, NHCOOA''R.sup.9, NHCONH.sub.2, NHCONHA''R.sup.9, NHCON(A''R.sup.9)(A'''R.sup.9), Hal, COOH, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)(A'''R.sup.9), ##STR00032## R.sup.8 is A, cycloalkyl having 3-7 carbon atoms or alkylenecycloalkyl having 4-8 carbon atoms, R.sup.9 is H, COOH, COOA, CONH.sub.2, CONHA, CONAA', NH.sub.2, NHA, NAA', NCOA, NCOOA, OH, OA, (CH.sub.2).sub.n-aryl or (CH.sub.2).sub.nHet, R.sup.10 is alkyl having 1-10 carbon atoms, cycloalkyl having 3-7 carbon atoms, alkylenecycloalkyl having 4-8 carbon atoms or alkenyl having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH, NMe, NEt and/or by --CH.dbd.CH-- groups, 1-7 H atoms may be replaced by F and/or Cl, and/or 1 H atom may be replaced by R.sup.9, R.sup.11 is H, A, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9, CON(A''R.sup.9)(A'''R.sup.9), NH.sub.2, NHA''R.sup.9, N(A''R.sup.9)(A'''R.sup.9), NCOA''R.sup.9, NCOOA''R.sup.9, OH or OA''R.sup.9, R.sup.12 is H, A, COOA''R.sup.9, CONH.sub.2, CONHA''R.sup.9 or CON(A''R.sup.9)(A'''R.sup.9), Y is alkylene having 1-10 carbon atoms or alkenylene having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH or NR.sup.10 and/or 1-7 H atoms may be replaced by F and/or Cl, A and A' are each, independently of one another, alkyl having 1-10 carbon atoms or alkenyl having 2-8 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH or NR.sup.10 and/or 1-7 H atoms may be replaced by F and/or Cl, or aryl or Het, A and A' together are alternatively an alkylene chain having 2-7 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH, NR.sup.10, NCOR.sup.10 or NCOOR.sup.10, A'' and A''' are each, independently of one another, absent, alkylene having 1-10 carbon atoms, alkenylene having 2-8 carbon atoms or cycloalkylene having 3-7 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH or NR.sup.10 and/or 1-7 H atoms may be replaced by F and/or Cl, A'' and A''' together are alternatively an alkylene chain having 2-7 carbon atoms, in which one, two or three CH.sub.2 groups may be replaced by O, S, SO, SO.sub.2, NH, NR.sup.10, NCOR.sup.10 or NCOOR.sup.10, aryl is phenyl, naphthyl, fluorenyl or biphenyl, each of which is unsubstituted or monosubstituted, disubstituted or trisubstituted by Hal, R.sup.14, OR.sup.13, N(R.sup.13).sub.2, NO.sub.2, CN, COOR.sup.13, CON(R.sup.13).sub.2, NR.sup.13COR.sup.13, NR.sup.13CON(R.sup.13).sub.2, NR.sup.13SO.sub.2A, COR.sup.13, SO.sub.2N(R.sup.13).sub.2 or S(O).sub.mR.sup.14, R.sup.13 is H or alkyl having 1-6 carbon atoms, R.sup.14 is alkyl having 1-6 carbon atoms, Het is a monocyclic or bicyclic saturated, unsaturated or aromatic heterocyclic ring having 1 or 2 N, O and/or S atoms, which may be unsubstituted or monosubstituted or disubstituted by oxo group, Hal, R.sup.14, OR.sup.13, N(R.sup.13).sub.2, NO.sub.2, CN, COOR.sup.13, CON(R.sup.13).sub.2, NR.sup.13COR.sup.13, NR.sup.13CON(R.sup.13).sub.2, NR.sup.13SO.sub.2R.sup.14, COR.sup.13, SO.sub.2NR.sup.13 and/or S(O).sub.mR.sup.14, Hal is F, Cl, Br or I, m is 0, 1 or 2, and n is 0, 1, 2, 3 or 4, or a pharmaceutically acceptable salt or a stereoisomer thereof, and a further pharmaceutically active compound; or a kit comprising separate packs of (a) a compound of formula I or a pharmaceutically acceptable salt or a stereoisomer thereof, and (b) a further pharmaceutically active compound. 17. A pharmaceutical composition or kit according to claim 16, wherein the further pharmaceutically active compound is a) leukotriene biosynthesis inhibitors, a 5-lipoxygenase (5-LO) inhibitor, 5-lipoxygenase activating protein (FLAP) antagonist, zileuton, ##STR00033## fenleuton, tepoxalin, ##STR00034## ##STR00035## N-(5-substituted) thiophene-2-alkylsulfonamide, 2,6-di-tert-butylphenol hydrazones, Zeneca ##STR00036## MK-886 or BAY x 1005; (b) receptor antagonists for the leukotrienes LTB.sub.4, LTC.sub.4, LTD.sub.4 or LTE.sub.4, ##STR00037## the benzoxazolamine compound ontazolast, ##STR00038## zafirlukast, ablukast, montelukast, pranlukast, verlukast (MK-679), iralukast (CGP 45715A) or BAY x 7195; (c) PDE IV inhibitors; (d) 5-lipoxygenase (5-LO) inhibitors; 5-lipoxygenase activating protein (FLAP) antagonists; (e) dual inhibitors of 5-lipoxygenase (5-LO) and antagonists of platelet activating factor (PAF); (f) leukotriene antagonists (LTRAs) (g) antihistamine H.sub.1 receptor antagonists, cetirizine, loratadine, desloratadine, fexofenadine, astemizole, azelastine or chlorpheniramine; (h) gastroprotective H.sub.2 receptor antagonists; (i) .alpha..sub.1- or .alpha..sub.2-adrenoreceptor agonist vasoconstrictor sympathomimetic agents administered orally or topically for decongestant use, propylhexedrine, phenylephrine, phenylpropanolamine, pseudoephedrine, naphazoline hydrochloride, oxymetazoline hydrochloride, tetrahydrozoline hydrochloride, xylometazoline hydrochloride or ethylnorepinephrine hydrochloride; (j) one or more .alpha..sub.1- or .alpha..sub.2-adrenoreceptor agonists as listed above under (i) in combination with one or more inhibitors of 5-lipoxygenase (5-LO) as listed above under (a); (k) anticholinergic agents, ipratropium bromide, tiotropium bromide, oxitropium bromide, pirenzepine or telenzepine; (l) .beta..sub.1- to .beta..sub.4-adrenoreceptor agonists, metaproterenol, isoproterenol, isoprenaline, albuterol, salbutamol, formoterol, salmeterol, terbutaline, orciprenaline, bitolterol or pirbuterol; (m) theophylline or aminophylline; (n) sodium cromoglycate; (o) muscarinic receptor (M1, M2 or M3) antagonists; (p) COX-1 inhibitors (NSAIDs) or nitric oxide NSAIDs; (q) the COX-2 selective inhibitor rofecoxib; (r) insulin-like growth factor type I (IGF-1) mimetics; (s) ciclesonide; (t) inhalation glucocorticoids with reduced systemic side effects, prednisone, prednisolone, flunisolide, triamcinolone acetonide, beclomethasone dipropionate, budesonide, fluticasone propionate or mometasone furoate; (u) tryptase inhibitors; (v) platelet activating factor (PAF) antagonists; (w) monoclonal antibodies against endogenous inflammatory entities; (y) antitumour necrosis factor (TNF .alpha.) agents, etanercept, or infliximab; (z) DMARDs, or leflunomide; (aa) TCR peptides; (bb) interleukin converting enzyme (ICE) inhibitors; (cc) IMPDH inhibitors; (dd) adhesion molecule inhibitors, or VLA-4 antagonists; (ee) cathepsins; (ff) MAP kinase inhibitors; (gg) glucose 6-phosphate dehydrogenase inhibitors; (hh) kinin B.sub.1 or B.sub.2 receptor antagonists; (ii) gold in the form of an aurothio group together with various hydrophilic groups; (jj) immunosuppressive agents, cyclosporine, azathioprine or methotrexate; (kk) anti-gout agents, or colchicines; (ll) xanthine oxidase inhibitors, or allopurinol; (mm) uricosuric agents, probenecide, sulfinpyrazone or benzbromarone; (nn) antineoplastic agents, which are antimitotic medicaments, or vinblastine or vincristine; (oo) agents for promoting growth hormone secretion; (pp) inhibitors of matrix metalloproteases (MMPs), stromelysins, collagenases, gelatinases, aggrecanase, collagenase-1 (MMP-1), collagenase-2 (MMP-8), collagenase-3 (MMP-13), stromelysin-1 (MMP-3), stromelysin-2 (MMP-10) or stromelysin-3 (MMP-11); (qq) transforming growth factor (TGF.beta.); (rr) platelet-derived growth factor (PDGF); (ss) fibroblast growth factor, or basic fibroblast growth factor (bFGF); (tt) granulocyte macrophage colony stimulating factor (GM-C SF); (uu) capsaicin; (vv) tachykinin NK.sub.1 or NK.sub.3 receptor antagonists, (ww) elastase inhibitors, or (xx) adenosine A2a receptor agonists. 18. A pharmaceutical composition or kit according to claim 16, wherein a compound of formula I or a pharmaceutically acceptable salt thereof is present in the composition or kit.

Details for Patent 7,563,790

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2022-06-05
Janssen Biotech, Inc.	REMICADE	infliximab	For Injection	103772	08/24/1998		2022-06-05
Immunex Corporation	ENBREL	etanercept	For Injection	103795	11/02/1998		2022-06-05