Claims for Patent: 7,560,436
✉ Email this page to a colleague
Summary for Patent: 7,560,436
Title: | Methods of treating gastrointestinal inflammation |
Abstract: | The present invention provides methods of treating gastrointestinal inflammation, methods of treating inflammatory bowel disease, methods of treating Crohn\'s Disease, and methods of treating ulcerative colitis in an individual. The methods generally involve administering an effective amount of an agent that increases the level of a Type I interferon and/or that activates a Type I interferon signaling pathway in the individual. |
Inventor(s): | Raz; Eyal (Del Mar, CA), Katakura; Kyoko (San Diego, CA), Lee; Jongdae (San Diego, CA), Rachmilewitz; Daniel (Tel Aviv, IL) |
Assignee: | The Regents of the University of California (Oakland, CA) |
Application Number: | 11/359,945 |
Patent Claims: | 1. A method for treating a gastrointestinal inflammatory disorder in an individual, the method comprising administering to a subject suffering from a gastrointestinal
inflammatory disorder an effective amount of Type I interferon activating agent that increases the level of a Type I interferon and/or activates a Type I interferon signaling pathway, wherein said Type I interferon activating agent is a chimeric
toll-like receptor (TLR) ligand comprising a TLR9 agonist moiety and a TLR8 agonist moiety, a chimeric TLR ligand comprising a TLR9 agonist moiety and a TLR7 agonist moiety, or a chimeric TLR ligand comprising a TLR7 agonist moiety and a TLR8 agonist
moiety.
2. The method of claim 1, wherein the TLR7 agonist moiety selected from an imidazoquinoline compound, a C8-substituted guanine ribonucleotides, and an N7, C8-substituted guanine ribonucleotide. 3. The method of claim 2, wherein the TLR7 agonist moiety is a selective TLR7 agonist. 4. The method of claim 1, wherein the TLR8 agonist moiety is an amide substituted imidazoquinoline amine. 5. The method of claim 4, wherein the TLR8 agonist moiety is a selective TLR8 agonist. 6. The method of claim 1, further comprising administering at least one additional therapeutic agent that treats a gastrointestinal inflammatory disorder. 7. The method of claim 6, wherein the at least one additional therapeutic agent is selected from an immunosuppressant, an anti-malarial agent, a TNF-.alpha. antagonist, an aminosalicylate, a corticosteroid, and a non-steroidal anti-inflammatory drug. 8. The method of claim 7, wherein the at least one additional therapeutic agent is an immunosuppressant selected from azothioprine, tacrolimus, cyclophosphamide, and cyclosporine. 9. The method of claim 7, wherein the at least one additional therapeutic agent is hydroxychloroquine. 10. The method of claim 7, wherein the at least one additional therapeutic agent is a TNF-.alpha. antagonist selected from etanercept, infliximab, and adalimumab. 11. The method of claim 7, wherein the at least one additional therapeutic agent is selected from 5-aminosalicylate, sulfasalazine, olsalazine and mesalamine. 12. The method of claim 7, wherein the at least one additional therapeutic agent is a corticosteroid selected from prednisolone, dexamethasone, hydrocortisone, and prednisone. 13. The method of claim 1, wherein said administering is by an oral route. 14. The method of claim 1, wherein said administering is by a subcutaneous route. 15. The method of claim 1, wherein said administering is by a rectal route. 16. The method of claim 1, wherein the gastrointestinal inflammatory disorder is chronic gastrointestinal inflammation. 17. The method of claim 1, wherein the chronic gastrointestinal inflammation is caused by inflammatory bowel disease. 18. The method of claim 1, wherein the inflammatory bowel disease is ulcerative colitis. 19. The method of claim 1, wherein the inflammatory bowel disease is Crohn's disease. 20. The method of claim 1, wherein the gastrointestinal inflammatory disorder is acute gastrointestinal inflammation. 21. The method of claim 1, wherein the gastrointestinal inflammatory disorder is pouchitis. 22. The method of claim 1, further comprising administering an effective amount of an IFN-.alpha.. 23. The method of claim 1, further comprising administering an effective amount of an IFN-.beta.. 24. The method of claim 1, wherein the individual is a human. |
Details for Patent 7,560,436
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Janssen Biotech, Inc. | REMICADE | infliximab | For Injection | 103772 | 08/24/1998 | ⤷ Try a Trial | 2025-02-22 |
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | 11/02/1998 | ⤷ Try a Trial | 2025-02-22 |
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | 05/27/1999 | ⤷ Try a Trial | 2025-02-22 |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | 09/27/2004 | ⤷ Try a Trial | 2025-02-22 |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | 02/01/2007 | ⤷ Try a Trial | 2025-02-22 |
Immunex Corporation | ENBREL MINI | etanercept | Injection | 103795 | 09/14/2017 | ⤷ Try a Trial | 2025-02-22 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
Make Better Decisions: Try a trial or see plans & pricing
Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.