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Last Updated: April 19, 2024

Claims for Patent: 7,534,443

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Summary for Patent: 7,534,443

Title:	Preparations for immunotherapy for cancer having bacterial somatic constituent as the active ingredient
Abstract:	An oil-in-water emulsion that comprise a bacterial component as an active ingredient as well as essentially an oil, surfactant, and a stabilizer, and that can be used as an agent for immunotherapy, and the preparation therefor are provided.
Inventor(s):	Azuma; Ichiro (Sapporo-shi, Hokkaido, JP), Hamamatsu; Norio (Kawanishi, JP), Fujinaga; Toshio (Ibaraki, JP)
Assignee:	Azuma; Ichiro (Hokkaido, JP) Hayashi; Akira (Osaka-fu, JP) Dainippon Sumitomo Pharma Co., Ltd. (Osaka-fu, JP)
Application Number:	09/743,750
Patent Claims:	1. An oil-in-water emulsion comprising a Bacillus Calmette-Guerin cell wall skeleton encapsulated in an oil wherein the emulsion is dispersed without any visible crude particles and which have an average fine particle size in the range of 0.1 .mu.m to 20 .mu.m, is negative for agglutination reaction with lectin, and is obtained by the following steps: (a) stirring a mixture of a Bacillus Calmette-Guerin cell wall skeleton, an oil, and an organic solvent to disperse the Bacillus Calmette-Guerin cell wall skeleton in the mixture; (b) evaporating off the organic solvent to form an oil wherein the Bacillus Calmette-Guerin cell wall skeleton is homogeneously dispersed, or an oil droplet wherein the Bacillus Calmette-Guerin cell wall skeleton is encapsulated in the oil; and then, (c) adding an aqueous solution containing a surfactant thereto, and emulsifying the mixture. 2. The oil-in-water emulsion of claim 1, wherein the organic solvent is selected from the group consisting of an aromatic hydrocarbon, an aliphatic hydrocarbon, a halogenated hydrocarbon, a lower alcohol, an acetate, an ether and a ketone. 3. The oil-in-water emulsion of claim 1, wherein the organic solvent is ethanol or toluene. 4. The oil-in-water emulsion of claim 1 or 3, wherein the oil is squalane.

Details for Patent 7,534,443

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Teknika Llc	TICE BCG	bcg live	For Injection	102821	06/21/1989	⤷ Try a Trial	2018-07-16
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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