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Last Updated: March 28, 2024

Claims for Patent: 7,452,902


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Summary for Patent: 7,452,902
Title:Imidazopyridines as cyclin dependent kinase inhibitors
Abstract: In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
Inventor(s): Dwyer; Michael P. (Scotch Plains, NJ), Guzi; Timothy J. (Chatham, NJ), Paruch; Kamil (Garwood, NJ), Doll; Ronald J. (Convent Station, NJ), Keertikar; Kartik M. (East Windsor, NJ), Girijavallabhan; Viyyoor M. (Parsippany, NJ)
Assignee: Schering Corporation (Kenilworth, NJ)
Application Number:11/238,597
Patent Claims:1. A method of inhibiting cyclin dependent kinase ("CDK2"), comprising administering a therapeutically effective amount of at least one compound to a patient or a pharmaceutically acceptable salt of the compound, said compound being selected from the group consisting of the following compounds: ##STR00230## ##STR00231## ##STR00232## ##STR00233## ##STR00234## ##STR00235##

2. The method of claim 1, further comprising radiation therapy.

3. A pharmaceutical composition comprising a therapeutically effective amount of at least one compound in combination with at least one pharmaceutically acceptable carrier, additionally comprising one or more anti-cancer agents selected from the group consisting of a cytostatic agent, cisplatin, doxorubicin, taxotere, taxol, etoposide, CPT-11, irinotecan, camptostar, topotecan, paclitaxel, docetaxel, epothilones, tamoxifen, 5-fluorouracil, methoxtrexate, 5FU, temozolomide, cyclophosphamide, SCH 66336, R115777, L778,123, BMS 214662, Iressa, Tarceva, antibodies to EGFR, Gleevec, intron, ara-C, adriamycin, cytoxan, gemcitabine, Uracil mustard, Chlormethine, Ifosfamide, Melphalan, Chlorambucil, Pipobroman, Triethylenemelamine, Triethylenethiophosphoramine, Busulfan, Carmustine, Lomustine, Streptozocin, Dacarbazine, Floxuridine, Cytarabine, 6-Mercaptopurine, 6-Thioguanine, Fludarabine phosphate, Pentostatine, Vinblastine, Vincristine, Vindesine, Bleomycin, Dactinomycin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Mithramycin, Deoxycoformycin, Mitomycin-C, L-Asparaginase, Teniposide 17.alpha.-Ethinylestradiol, Diethyistilbestrol, Testosterone, Prednisone, Fluoxymesterone, Dromostanolone propionate, Testolactone, Megestrolacetate, Methylprednisolone, Methyltestosterone, Prednisolone, Triamcinolone, Chlorotrianisene, Hydroxyprogesterone, Aminoglutethimide, Estramustine, Medroxyprogesteroneacetate, Leuprolide, Flutamide, Toremifene, goserelin, Cisplatin, Carboplatin, Hydroxyurea, Amsacrine, Procarbazine, Mitotane, Mitoxantrone, Levamisole, Navelbene, CPT-11, Anastrazole, Letrazole, Capecitabine, Reloxafine, Droloxafine, or Hexamethylmelamine, wherein said at least one compound is selected from the group consisting of the compounds of the structures: ##STR00236## ##STR00237## ##STR00238## ##STR00239## ##STR00240## ##STR00241##

Details for Patent 7,452,902

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Recordati Rare Diseases, Inc. ELSPAR asparaginase For Injection 101063 01/10/1978 ⤷  Try a Trial 2022-09-19
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 06/04/1986 ⤷  Try a Trial 2022-09-19
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b For Injection 103132 ⤷  Try a Trial 2022-09-19
Merck Sharp & Dohme Corp. INTRON A interferon alfa-2b Injection 103132 ⤷  Try a Trial 2022-09-19
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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