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Last Updated: March 29, 2024

Claims for Patent: 7,449,181


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Summary for Patent: 7,449,181
Title:Remedies for cancer
Abstract: A medicament for treating cancer for use in combination therapy with an anti-HER2 antibody, which comprises amrubicin or a pharmaceutically acceptable salt thereof as an active ingredient.
Inventor(s): Noguchi; Toshihiro (Ibaraki, JP), Baba; Akemi (Oklahoma City, OK), Hanada; Mitsuharu (Ibaraki, JP)
Assignee: Sumitomo Pharmaceuticals Company Limited (Osaka-Shi, JP)
Application Number:10/333,978
Patent Claims:1. A method of treating breast cancer, which is a breast cancer in which HER2 is highly expressed, comprising administering an effective amount of trastuzumab and an effective amount of amrubicin or a pharmaceutically acceptable salt thereof in combination, whereby said breast cancer is treated.

2. The method according to claim 1, comprising administering amrubicin or a pharmaceutically acceptable salt thereof at 0.5 3.0 mg/kg/day while administering trastuzumab at 0.1 4.5 mg/kg/day.

3. The method according to claim 2, comprising administering amrubicin or a pharmaceutically acceptable salt thereof on successive three days in every three weeks, while administering trastuzumab every one week.

4. The method according to claim 1, comprising administering amrubicin or a pharmaceutically acceptable salt thereof at 1.5 9.0 mg/kg/day while administering trastuzumab at 0.1 4.5 mg/kg/day.

5. The method according to claim 4, comprising administering amrubicin or a pharmaceutically acceptable salt thereof every three weeks, while administering trastuzumab every one week.

6. The method according to any one of claims 1 and 2 to 5, wherein a dosage ratio of amrubicin or a pharmaceutically acceptable salt thereof and trastuzumab is 2:1 8:1 at one week after initiating the administration of both agents.

Details for Patent 7,449,181

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 09/25/1998 ⤷  Try a Trial 2020-07-28
Genentech, Inc. HERCEPTIN trastuzumab For Injection 103792 02/10/2017 ⤷  Try a Trial 2020-07-28
Genentech, Inc. HERCEPTIN HYLECTA trastuzumab and hyaluronidase-oysk Injection 761106 02/28/2019 ⤷  Try a Trial 2020-07-28
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

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