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Last Updated: April 19, 2024

Claims for Patent: 7,371,410

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Summary for Patent: 7,371,410

Title:	Bone graft substitute composition
Abstract:	A bone graft substitute composition can include essentially of calcium sulfate, a mixing solution, and a plasticizing substance. A bone graft substitute composition can include calcium sulfate, demineralized bone matrix, cancellous bone, a plasticizing substance, and a mixing solution.
Inventor(s):	Petersen; Donald W. (Bessemer, AL)
Assignee:	Wright Medical Technology, Inc. (Arlington, TX)
Application Number:	10/060,697
Patent Claims:	1. A bone graft substitute composition, comprising: calcium sulfate; demineralized bone matrix; cancellous bone; plasticizing substance; and a mixing solution. 2. The composition of claim 1, wherein the calcium sulfate comprises calcium sulfate hemihydrate. 3. The composition of claim 1, wherein the plasticizing substance comprises a cellulose derivative. 4. The composition of claim 1, wherein the plasticizing substance is selected from a group consisting of sodium carboxymethylcellulose, methylcellulose, hydroxypropyl methyl cellulose, hydroxypropyl cellulose, ethylcellulose, hydroxyethylcellulose, and cellulose acetate butyrate. 5. The composition of claim 1, wherein the mixing solution is selected from a group consisting of sterile water, inorganic salt, and cationic surface active agent. 6. The composition of claim 5, wherein the cationic surface active agent is selected from a group consisting of sodium chloride, phosphate buffered saline, potassium chloride, sodium sulfate, ammonium sulfate, ammonium acetate, and sodium acetate. 7. The composition of claim 1, wherein the mixing solution comprises sterile water. 8. The composition of claim 1, comprising: about 80 to about 120 parts by weight of calcium sulfate; about 10 to about 100 parts by weight of demineralized bone matrix; about 10 to about 100 parts by weight of cancellous bone; about 1 to about 40 parts by weight of a plasticizing substance; and about 21 to about 250 parts by weight of a mixing solution. 9. The composition of claim 1, comprising: about 90 to about 110 parts by weight of calcium sulfate; about 10 to about 50 parts by weight of demineralized bone matrix; about 15 to about 50 parts by weight of cancellous bone; about 5 to about 20 parts by weight of a plasticizing substance; and about 80 to about 120 parts by weight of a mixing solution. 10. The composition of claim 1, comprising: about 98 to about 102 parts by weight of calcium sulfate; about 13 to about 23 parts by weight of demineralized bone matrix; about 27 to about 33 parts by weight of cancellous bone; about 15 to about 20 parts by weight of a plasticizing substance; and about 95 to about 105 parts by weight of a mixing solution. 11. The composition of claim 1, comprising: about 100 parts by weight of calcium sulfate; about 18 to about 19 parts by weight of demineralized bone matrix; about 27 to about 28 parts by weight of cancellous bone; about 17 to about 18 parts by weight of a plasticizing substance; and about 101 to about 102 parts by weight of a mixing solution. 12. A bone graft substitute composition, comprising: about 80 to about 120 parts by weight of calcium sulfate hemihydrate; about 10 to about 100 parts by weight of demineralized bone matrix; about 10 to about 100 parts by weight of cancellous bone; about 1 to about 40 parts by weight of a carboxymethylcellulose; and about 21 to about 250 parts by weight of sterile water. 13. The composition of claim 12, comprising: about 90 to about 110 parts by weight of calcium sulfate hemihydrate; about 10 to about 50 parts by weight of demineralized bone matrix; about 15 to about 50 parts by weight of cancellous bone; about 5 to about 20 parts by weight of carboxymethylcellulose; and about 80 to about 120 parts by weight of sterile water. 14. The composition of claim 12, comprising: about 98 to about 102 parts by weight of calcium sulfate hydrate; about 13 to about 23 parts by weight of demineralized bone matrix; about 27 to about 33 parts by weight of cancellous bone; about 15 to about 20 parts by weight of carboxymethylcellulose; and about 95 to about 105 parts by weight of sterile water. 15. The composition of claim 12, comprising: about 100 parts by weight of calcium sulfate hemihydrate; about 18 to about 19 parts by weight of demineralized bone matrix; about 27 to about 28 parts by weight of cancellous bone; about 17 to about 18 parts by weight of carboxymethylcellulose; and about 101 to about 102 parts by weight of sterile water.

Details for Patent 7,371,410

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Merck Sharp & Dohme Corp.	ZOSTAVAX	zoster vaccine live	For Injection	125123	05/25/2006	⤷ Try a Trial	2019-06-07
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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