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Last Updated: March 28, 2024

Claims for Patent: 7,371,408


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Summary for Patent: 7,371,408
Title:Bone graft substitute composition
Abstract: A bone graft substitute composition comprising calcium sulfate; a mixing solution selected from the group consisting of sterile water, sodium chloride, phosphate buffered saline, potassium chloride, and sodium sulfate; and a plasticizing substance selected from the group consisting of carboxymethylcellulose, polyvinyl alcohol, methycellulose, and hydroxypropyl methylcellulose.
Inventor(s): Petersen; Donald W. (Lakeland, TN), Haggard; Warren O. (Bartlett, TN), Randolph; Donald A. (Wheaton, IL), Hagan; Cary P. (Germantown, TN)
Assignee: Wright Medical Technology, Inc. (Arlington, TN)
Application Number:09/327,761
Patent Litigation and PTAB cases: See patent lawsuits and PTAB cases for patent 7,371,408
Patent Claims:1. A bone graft substitute composition comprising: (a) calcium sulfate; (b) a mixing solution; (c) a cellulose derivative plasticizing agent; and (d) demineralized bone.

2. The bone graft substitute composition of claim 1, comprising approximately 40% demineralized bone matrix by dry weight.

3. The bone graft substitute composition of claim 1, wherein the mixing solution is selected from a group consisting of sterile water, an inorganic salt, and a cationic surface active agent.

4. The bone graft substitute composition of claim 3, wherein the cationic surface agent is selected from a group consisting of sodium chloride, phosphate buffered saline, potassium chloride, sodium sulfate, ammonium sulfate, ammonium acetate, and sodium acetate.

5. The bone graft substitute composition of claim 1, wherein the mixing solution comprises sterile water.

6. The bone graft substitute composition of claim 1, wherein the cellulose derivative is selected from a group consisting of sodium carboxymethylcellulose, methylcellulose, hydroxypropyl methylcellulose, ethylcellulose, hydroxyethylcellulose and cellulose acetate butyrate.

7. The bone graft substitute composition of claim 1, wherein the cellulose derivative comprises carboxymethylcellulose.

8. The bone graft substitute composition of claim 1, wherein the calcium sulfate comprises calcium sulfate hemihydrate.

9. The bone graft substitute composition of claim 1, wherein the calcium sulfate comprises calcium sulfate hemihydrate, the mixing solution comprises sterile water, and the cellulose derivative comprises carboxymethylcellulose.

10. The bone graft substitute composition of claim 9, comprising approximately 100 parts calcium sulfate hemihydrate by weight, approximately 11.1 parts carboxymethylcellulose by weight, approximately 162 parts water by weight, and approximately 69.4 parts demineralized bone matrix by weight.

11. A bone graft substitute composition comprising: (a) approximately 80-120 parts medical grade calcium sulfate hemihydrate by weight; (b) approximately 21-250 parts sterile water by weight; (c) approximately 1-40 parts carboxymethylcellulose by weight; and (d) approximately 10-100 parts demineralized bone matrix by weight.

12. The bone graft substitute composition of any one of claims 1 to 11, further comprising a bone allograft.

13. A method of making a bone graft substitute composition, the method comprising: providing a first composition comprising calcium sulfate, a cellulose derivative plasticizing agent and demineralized bone matrix; and contacting the first composition with a mixing solution to form the bone graft substitute composition.

14. The method of claim 13, wherein the first composition further comprises a bone allograft.

15. The method of claim 13, further comprising forming the bone graft substitute composition into a putty.

16. The method of claim 13, wherein the calcium sulfate comprises calcium sulfate hemihydrate, the cellulose derivative comprises carboxymethylcellulose, and the mixing solution comprises sterile water.

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