Claims for Patent: 7,354,574
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Summary for Patent: 7,354,574
Title: | Treatment of ocular disease |
Abstract: | A method and article to treat ocular disease with Cyclosporin A alone or with compounds related to Cyclosporin A for intraocular injection or implantation. Treatment does not result in ocular toxicity and encompasses age related macular degeneration, retinitis pigmentosa, and retinopathy such as diabetic retinopathy. |
Inventor(s): | Peyman; Gholam A. (New Orleans, LA) |
Assignee: | Advanced Ocular Systems Limited (Nedlands, AU) |
Application Number: | 10/289,772 |
Patent Claims: | 1. A method of treating diabetic retinopathy or retinitis pigmentosa in a patient in need thereof comprising intraocularly injecting a composition consisting
essentially of Cyclosporin A in a pharmaceutically acceptable formulation and in an amount effective to treat diabetic retinopathy or retinitis pigmentosa without substantial toxicity to the patient.
2. The method of claim 1 comprising administering by retrobulbar, intravitreal, intraretinal, or subconjunctival injection. 3. The method of claim 1 wherein injection is subconjunctival at a dose in the range of about 1 ng/ml to about 500 .mu.g/ml, intravitreal at a dose in the range of about 1 .mu.g/0.1 ml to about 1000 .mu.g/0.1 ml, retrobulbar at a dose in the range of about 20 .mu.g/ml to about 1000 .mu.g/ml, or subretinal at a dose in the range of about 1 .mu.g/0.1 ml to about 100 .mu.g/0.1 ml. 4. The method of claim 1 wherein Cyclosporin A is injected at a dose in the range of about 20 .mu.g/ml to about 1000 .mu.g/ml. 5. A method of treating diabetic retinopathy or retinitis pigmentosa in a patient in need thereof comprising intraocularly injecting a composition comprising Cyclosporin A in a pharmaceutically acceptable formulation and in an amount effective to treat diabetic retinopathy or retinitis pigmentosa without substantial toxicity to the patient. 6. The method of claim 5 comprising administering by retrobulbar, intravitreal, intraretinal, or subconjunctival injection. 7. The method of claim 5 wherein the composition further comprises an immunosuppressant selected from the group consisting of tacrolimus, cyclosphosphamide, sirolimus, atoposide, thiotepa, methotrexate, azathioprine, interferons, infliximab, etanercept, mycophenolate mofetil, 15-deoxyspergualin, thalidomide, glatiramer, leflunomide, vincristine, cytarabine, and combinations thereof. 8. The method of claim 1 wherein Cyclosporin A is provided in at least one of a microsphere, liposome, capsule or polymeric matrix. 9. The method of claim 5 wherein Cyclosporin A is provided in at least one of a microsphere, liposome, capsule or polymeric matrix. 10. A method of treating macular degeneration, diabetic retinopathy or retinitis pigmentosa in a patient in need thereof comprising intraocularly injecting a composition comprising Cyclosporin A in a pharmaceutically acceptable formulation and in an amount effective to treat macular degeneration, diabetic retinopathy, or retinitis pigmentosa without substantial toxicity to the patient, wherein injection is subconjuctival at a dose in the range of about 1 .mu.g/ml to about 500 .mu.g/ml, intravitreal at a dose in the range of about 1 .mu.g/0.1 ml to about 1000 .mu.g/0.1 ml, retrobulbar at a dose in the range of about 20 .mu.g/ml to about 1000 .mu.g/ml, or subretinal at a dose in the range of about 1 .mu.g/0.1 ml to about 1000 .mu.g/0.1 ml. 11. A method of treating macular degeneration, diabetic retinopathy or retinitis pigmentosa in a patient in need thereof comprising intraocularly injecting a composition comprising Cyclosporin A in a pharmaceutically acceptable formulation and in an amount effective to treat macular degeneration, diabetic retinopathy, or retinitis pigmentosa without substantial toxicity to the patient, wherein Cyclosporin A is injected at a dose in the range of about 20 .mu.g/ml to about 1000 .mu.g/ml. |
Details for Patent 7,354,574
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Janssen Biotech, Inc. | REMICADE | infliximab | For Injection | 103772 | 08/24/1998 | ⤷ Try a Trial | 2039-02-26 |
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | 11/02/1998 | ⤷ Try a Trial | 2039-02-26 |
Immunex Corporation | ENBREL | etanercept | For Injection | 103795 | 05/27/1999 | ⤷ Try a Trial | 2039-02-26 |
Immunex Corporation | ENBREL | etanercept | Injection | 103795 | 09/27/2004 | ⤷ Try a Trial | 2039-02-26 |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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