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Last Updated: April 16, 2024

Claims for Patent: 7,351,249

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Summary for Patent: 7,351,249

Title:	Systems, methods, and compositions for achieving closure of suture sites
Abstract:	Systems and methods employ functional instruments to close incisions and wounds using a suture knot in combination with a biocompatible material composition. The systems and methods are well suited for use, for example, at a vascular puncture site following a vascular access procedure.
Inventor(s):	Hnojewyj; Olexander (Saratoga, CA), Addis; Bruce (Redwood City, CA), Browne; Daniel (Palo Alto, CA), Cheung; David (Santa Cruz, CA)
Assignee:	NeoMend, Inc. (Irvine, CA)
Application Number:	10/212,472
Patent Claims:	1. A method for sealing a suture knot comprising the steps of placing a suture loop through tissue to join tissue, tying the suture loop to form a suture knot, and discharging a liquid closure material comprising an electrophilic component comprising a hydrophilic, biocompatible polymer that is electrophilically derivatized with a functionality of at least three and a solution containing a nucleophilic component comprising recombinant or natural serum albumin in a concentration of 25% or less and a buffer component adjacent the suture knot, the liquid closure material cross-linking after discharge to form a solid closure adjacent the suture knot having cohesive and tissue adhesive strength to impede blood flow without clot formation. 2. A method according to claim 1 wherein the forming step includes manipulating a knot pusher. 3. A method according to claim 2 wherein the discharging step includes discharging the liquid closure material through the knot pusher. 4. A method according to claim 1 wherein the polymer comprises poly(ethylene glycol) (PEG). 5. A method according to claim 4 wherein the recombinant or natural serum albumin comprises human serum albumin. 6. A method for sealing a puncture site in a blood vessel comprising the steps of placing a suture loop through tissue on opposite sides of the puncture site, tying the suture loop to form a suture knot at the puncture site, and discharging a liquid closure material comprising an electrophilic component comprising a hydrophilic, biocompatible polymer that is electrophilically derivatized with a functionality of at least three and a solution containing a nucleophilic component comprising recombinant or natural serum albumin in a concentration of 25% or less and a buffer component adjacent the suture knot, the liquid closure material cross-linking after discharge to form a solid closure adjacent the suture knot having cohesive and tissue adhesive strength to impede blood flow without clot formation. 7. A method according to claim 6 wherein the forming step includes manipulating a knot pusher. 8. A method according to claim 7 wherein the discharging step includes discharging the liquid closure material through the knot pusher. 9. A method according to claim 6 wherein the polymer comprises poly(ethylene glycol) (PEG). 10. A method according to claim 9 wherein the recombinant or natural serum albumin comprises human serum albumin.

Details for Patent 7,351,249

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2018-11-06
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2018-11-06
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2018-11-06
Grifols Biologicals Llc	ALBUTEIN	albumin (human)	Injection	102478	08/15/1978	⤷ Try a Trial	2018-11-06
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	02/17/1995	⤷ Try a Trial	2018-11-06
Instituto Grifols, S.a.	HUMAN ALBUMIN GRIFOLS	albumin (human)	Injection	103352	06/11/2003	⤷ Try a Trial	2018-11-06
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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