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Last Updated: March 28, 2024

Claims for Patent: 7,332,160


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Summary for Patent: 7,332,160
Title:Medical device and method for tissue removal and repair
Abstract: The present invention relates to medical devices that are to be implanted or inserted into the body of a patient for the purpose of removing undesired body tissues. In one embodiment of the invention the medical device comprises a body tissue removal agent for removing undesired body tissue simultaneously with or prior to treatment of body tissue that is in proximity to the undesired body tissue with a biologically active material. Such biologically active material may facilitate regeneration of the body tissue that was removed or may prevent the recurrence of the undesired body tissue.
Inventor(s): Freyman; Toby (Watertown, MA), Naimark; Wendy (Cambridge, MA)
Assignee: Boston Scientific Scimed, Inc. (Maple Grove, MN)
Application Number:10/194,762
Patent Claims:1. A medical device for removing undesired body tissue of a patient prior to or simultaneously with treating body tissue in proximity to the undesired body tissue, wherein the device is a stent comprising a sidewall having a plurality of openings therein, the sidewall having a coating disposed thereon, said coating comprising: (a) an inner layer comprising a biologically active material selected from the group consisting of anti-thrombotics, thrombolytics, anti-proliferative agents, and growth factors; and (b) an outer layer comprising a body tissue removal agent for facilitating the removal of the undesired body tissue prior to or simultaneously with administration of the biologically active material to the body tissue in proximity to the undesired body tissue, wherein the biologically active material and the body tissue removal agent are different.

2. The medical device of claim 1, wherein the medical device comprises a biodegradable polymeric material which comprises the body tissue removal agent.

3. The medical device of claim 1, wherein the body tissue removal agent is selected from the group consisting of collagenase, dispase, trypsin, papain, acetic acid, and cytokines that mediate the removal of the undesired body tissue.

4. The medical device of claim 1, wherein the anti-proliferative agent is paclitaxel.

5. A medical device for removing undesired body tissue of a patient prior to or simultaneously with treating body tissue in proximity to the undesired body tissue, the device comprising an expandable balloon and a coating disposed thereon, wherein the coating comprises: (a) an inner layer comprising a biologically active material selected from the group consisting of anti-thrombotics, thrombolytics, anti-proliferative agents, and growth factors; and (b) an outer layer comprising a body tissue removal agent for facilitating the removal of the undesired body tissue prior to or simultaneously with administration of the biologically active material to the body tissue in proximity to the undesired body tissue, wherein the biologically active material and the body tissue removal agent are different.

6. The medical device of claim 5, wherein the outer layer of the medical device comprises a biodegradable polymeric material which comprises the body tissue removal agent.

7. The medical device of claim 5, wherein the body tissue removal agent is selected from the group consisting of collagenase, dispose, trypsin, papain, acetic acid, and cytokines that mediate the removal of the undesired body tissue.

8. The medical device of claim 5, wherein the anti-proliferative agent is paclitaxel.

9. A medical device for removing undesired body tissue of a patient prior to or simultaneously with treating body tissue in proximity to the undesired body tissue, wherein the device is a microsphere that is injectable into body tissue of the patient comprising: (a) an inner layer which is a core comprising a biologically active material selected from the group consisting of anti-thrombotics, anti-proliferative agents, thrombolytics, and growth factors; and (b) an outer layer comprising a body tissue removal agent for facilitating the removal of the undesired body tissue prior to or simultaneously with administration of the biologically active material to the body tissue in proximity to the undesired body tissue, wherein the biologically active material and the body tissue removal agent are different.

10. The medical device of claim 9, wherein the medical device comprises a biodegradable polymeric material which comprises the body tissue removal agent.

11. The medical device of claim 9, wherein the body tissue removal agent is selected from the group consisting of collagenase, dispase, trypsin, papain, acetic acid, and cytokines that mediate the removal of the undesired body tissue.

12. The medical device of claim 9, wherein the inner and the outer layers are separated by a biodegradable membrane that degrades over time.

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