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Last Updated: March 29, 2024

Claims for Patent: 7,270,968


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Summary for Patent: 7,270,968
Title:PTH analogs for renal osteodystrophy and related uses
Abstract: The invention relates to a mammalian cell lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1R) activity and containing carboxyl-terminal parathyroid hormone receptor (CPTHR) activity. The invention also relates to a method of screening for agonists or antagonists for CPTHR.
Inventor(s): Bringhurst; F. Richard (Walpole, MA), Divieti; Paola (Arlington, MA), Juppner; Harald (Cambridge, MA)
Assignee: The General Hospital Corporation (Boston, MA)
Application Number:10/344,744
Patent Claims:1. An isolated osteocyte lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1R) activity and containing carboxyl-terminal parathyroid hormone receptor (CPTHR) activity.

2. The cell of claim 1, wherein said osteocyte is homozygous for the ablation of the PTH1R gene.

3. A method of screening for agonists or antagonists for carboxyl-terminal parathyroid hormone receptor (CPTHR), said method comprising: (a) contacting an isolated osteocyte lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1R) activity and containing CPTHR activity with a candidate compound; and (b) determining the rate of apoptosis of said cell, wherein an accelerated rate of apoptosis compared to said osteocyte not contacted with a candidate compound indicates that said compound is an agonist for CPTHR, and wherein a rate of apoptosis equal to or less than said osteocyte not contacted with a candidate compound indicates that said compound is an antagonist for CPTHR.

4. The method of claim 3, wherein said osteocyte is homozygous for the ablation of the PTH1R gene.

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