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Last Updated: April 19, 2024

Claims for Patent: 7,198,949

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Summary for Patent: 7,198,949

Title:	Compositions and methods for altering the biodistribution of biological agents
Abstract:	The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.
Inventor(s):	Porter; Thomas R. (Omaha, NE), Iversen; Patrick L. (Corvallis, OR)
Assignee:	Board of Regents of the University of Nebraska (Lincoln, NE)
Application Number:	10/668,448
Patent Claims:	1. A method for delivering a biological agent to the site of a tumor in a subject, comprising: administering to a subject having said tumor a composition comprising said agent and a suspension of microbubbles which are encapsulated with a filmogenic protein selected from the group consisting of albumin, human gamma globulin, human apotransferrin, beta lactase and urease and contain a gas selected from a perfluorocarbon and SF.sub.6. 2. The method of claim 1, wherein said composition is formed by incubating said agent with said suspension of microbubbles. 3. The method of claim 1, wherein the gas is a perfluorocarbon selected from the group consisting of perfluoromethane, perfluoroethane, perfluoropropane, perfluorobutane, and perfluoropentane. 4. The method of claim 1, wherein said administration is carried out without application of ultrasound to said composition during or following administration. 5. The method of claim 1, wherein said composition is administered intravenously. 6. A composition comprising a suspension of microbubbles which are encapsulated with a filmogenic protein selected from the group consisting of albumin, human gamma globulin, human apotransferrin, beta lactase and urease and contain a gas selected from a perfluorocarbon and SF.sub.6, and a medicament which binds to said filmogenic protein. 7. The composition of claim 6, wherein said composition is formed by incubating said medicament with said suspension of microbubbles. 8. The composition of claim 7, wherein the gas is a perfluorocarbon selected from the group consisting of perfluoromethane, perfluoroethane, perfluoropropane, perfluorobutane, and perfluoropentane.

Details for Patent 7,198,949

Glossary

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Grifols Therapeutics Llc	ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5	albumin (human)	For Injection	101138	10/21/1942	⤷ Try a Trial	2016-06-28
Baxalta Us Inc.	BUMINATE, FLEXBUMIN	albumin (human)	Injection	101452	03/03/1954	⤷ Try a Trial	2016-06-28
Csl Behring Ag	ALBURX	albumin (human)	Injection	102366	07/23/1976	⤷ Try a Trial	2016-06-28
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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