You’re using a public version of DrugPatentWatch with 5 free searches available | Register to unlock more free searches. CREATE FREE ACCOUNT

Last Updated: March 29, 2024

Claims for Patent: 7,115,583


✉ Email this page to a colleague

« Back to Dashboard


Summary for Patent: 7,115,583
Title:Microbubble compositions and methods for oligonucleotide delivery
Abstract: The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.
Inventor(s): Porter; Thomas R. (Omaha, NE), Iversen; Patrick L. (Corvallis, OR)
Assignee: AVI Biopharma, Inc. (Corvallis, OR)
Application Number:10/355,388
Patent Claims:1. A composition for administration of an oligonucleotide, comprising: a plurality of filmogenic protein-encapsulated insoluble gas-filled microbubbles, wherein the insoluble gas is a perfluorocarbon or SF.sub.6; and an oligonucleotide, wherein the oligonucleotide is conjugated to said protein at a microbubble surface, which filmogenic protein is selected from the group consisting of albumin, human gamma globulin, human apotransferin, beta lactase and urease, which filmogenic protein is selected from the group consisting of albumin, human gamma globulin, human apotransferrin, beta lactase and urease.

2. The composition of claim 1, wherein the gas is a perfluorocarbon gas selected from the group consisting of perfluoromethane, perfluoroethane, perfluoropropane, perfluorobutane, and perfluoropentane.

3. The composition of claim 1, wherein said microbubbles are 0.1 to 10 microns in diameter.

4. A composition for administration of an oligonucleotide, wherein said composition is formed by incubating said oligonucleotide with an aqueous suspension of filmogenic protein-encapsulated SF.sub.6-or perfluorocarbon gas-filled microbubbles, which filmogenic protein is selected from the group consisting of albumin, human gamma globulin, human apotransferin, beta lactase and urease, which filmogenic protein is selected from the group consisting of albumin, human gamma globulin, human apotransferrin, beta lactase and urease.

5. The composition of claim 4, wherein the gas is a perfluorocarbon gas selected from the group consisting of perfluoromethane, perfluoroethane, perfluoropropane, perfluorobutane, and perfluoropentane.

6. The composition of claim 4, wherein said microbubbles are 0.1 to 10 microns in diameter.

Details for Patent 7,115,583

Applicant Tradename Biologic Ingredient Dosage Form BLA Approval Date Patent No. Expiredate
Grifols Therapeutics Llc ALBUKED, PLASBUMIN-20, PLASBUMIN-25, PLASBUMIN-5 albumin (human) For Injection 101138 10/21/1942 ⤷  Try a Trial 2016-06-28
Baxalta Us Inc. BUMINATE, FLEXBUMIN albumin (human) Injection 101452 03/03/1954 ⤷  Try a Trial 2016-06-28
Csl Behring Ag ALBURX albumin (human) Injection 102366 07/23/1976 ⤷  Try a Trial 2016-06-28
>Applicant >Tradename >Biologic Ingredient >Dosage Form >BLA >Approval Date >Patent No. >Expiredate

Make Better Decisions: Try a trial or see plans & pricing

Drugs may be covered by multiple patents or regulatory protections. All trademarks and applicant names are the property of their respective owners or licensors. Although great care is taken in the proper and correct provision of this service, thinkBiotech LLC does not accept any responsibility for possible consequences of errors or omissions in the provided data. The data presented herein is for information purposes only. There is no warranty that the data contained herein is error free. thinkBiotech performs no independent verification of facts as provided by public sources nor are attempts made to provide legal or investing advice. Any reliance on data provided herein is done solely at the discretion of the user. Users of this service are advised to seek professional advice and independent confirmation before considering acting on any of the provided information. thinkBiotech LLC reserves the right to amend, extend or withdraw any part or all of the offered service without notice.