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Last Updated: April 24, 2024

Claims for Patent: 7,045,677

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Summary for Patent: 7,045,677

Title:	Fusion proteins incorporating lysozyme
Abstract:	A process for the production of a peptide is disclosed, the process comprising expressing in the milk of a transgenic, non-human, placental mammal a fusion protein which comprises the peptide to be expressed linked to a fusion partner protein which is lysozyme. The fusion protein may be separate from the milk and cleaved to yield the target peptide. A transgenic, non-human, placental mammal whose genome incorporates a DNA molecule comprising a coding sequence encoding lysozyme coupled to a peptide is also described.
Inventor(s):	Cottingham; Ian Robert (Edinburgh, GB), McCreath; Graham Edward (Edinburgh, GB)
Assignee:	Pharming Intellectual Property BV (Al Leiden, NL)
Application Number:	10/024,597
Patent Claims:	1. A transgenic non-human placental mammal whose genome incorporates a DNA molecule comprising a coding sequence operably linked to a control sequence which comprises a promoter from a gene encoding a naturally-derived milk protein, wherein said coding sequence comprises in order a first segment encoding a fusion partner protein which is lysozyme coupled in-frame to a second segment encoding a peptide other than a protein leader sequence and wherein said fusion protein is expressed in the milk of said transgenic animal. 2. A transgenic mammal as claimed in claim 1, wherein said mammal is selected from the group consisting of a cow, a sheep, a goat, a rabbit, a mouse and a pig. 3. The transgenic animal of claim 1, wherein said promoter sequence is a .beta.-lactoglobulin promoter. 4. The transgenic animal of claim 1, wherein said second segment encodes a peptide selected from the group consisting of: (a) calcitonin; (b) parathyroid hormone; (c) glucagon; (d) glucagon-like-peptide-1; (e) a magainin; (f) a histatin; (g) a protegrin; and (h) a clavanin. 5. The transgenic animal of claim 1, wherein said lysozyme is human lysozyme.

Details for Patent 7,045,677

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Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Nps Pharmaceuticals, Inc.	NATPARA	parathyroid hormone	For Injection	125511	01/23/2015	⤷ Try a Trial	2020-06-02
>Applicant	>Tradename	>Biologic Ingredient	>Dosage Form	>BLA	>Approval Date	>Patent No.	>Expiredate

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