Claims for Patent: 7,037,647
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Summary for Patent: 7,037,647
Title: | Prostate-specific membrane antigen and uses thereof |
Abstract: | This invention provides an isolated mammalian nucleic acid molecule encoding an alternatively spliced prostate-specific membrane (PSM\') antigen. This invention provides an isolated nucleic acid molecule encoding a prostate-specific membrane antigen promoter. This invention provides a method of detecting hematogenous micrometastic tumor cells of a subject, and determining prostate cancer progression in a subject. |
Inventor(s): | Israeli; Ron S. (Staten Island, NY), Heston; Warren D. W. (New York, NY), Fair; William R. (New York, NY) |
Assignee: | Sloan-Kettering Institute for Cancer Research (New York, NY) |
Application Number: | 08/894,583 |
Patent Claims: | 1. A method of detecting expression of an alternatively spliced prostate specific membrane antigen in a cell or tissue, which alternatively spliced prostate specific
membrane antigen consists essentially of consecutive amino acids, the amino acid sequence of which is set forth in SEQ ID NO:128 beginning with methionine at position number 58 and ending with alanine at position number 750, the nucleic acid encoding the
alternatively spliced prostate specific membrane antigen having an intron splice site located between the G and T nucleotides at positions 114 and 115, respectively, as set forth in SEQ ID NO:1, wherein a splice at said site results in formation of an
exon-exon junction characteristic of said alternatively spliced prostate specific membrane antigen, said method comprising: (1) contacting mRNA obtained from the cell or tissue with a detectable nucleic acid of at least 15 nucleotides in length which
specifically hybridizes across said exon-exon junction; and (2) determining whether the detectable nucleic acid hybridizes to the mRNA, wherein the presence of the detectable nucleic acid hybridized to the mRNA indicates expression of alternatively
spliced prostate specific membrane antigen in the cell or tissue.
2. The method of claim 1, wherein the detectable nucleic acid is labeled with a detectable label. 3. The method of claim 2, wherein the detectable label is a radioisotope or fluorescent dye. |
Details for Patent 7,037,647
Applicant | Tradename | Biologic Ingredient | Dosage Form | BLA | Approval Date | Patent No. | Expiredate |
---|---|---|---|---|---|---|---|
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | 06/04/1986 | ⤷ Try a Trial | 2015-02-24 |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | For Injection | 103132 | ⤷ Try a Trial | 2015-02-24 | |
Merck Sharp & Dohme Corp. | INTRON A | interferon alfa-2b | Injection | 103132 | ⤷ Try a Trial | 2015-02-24 | |
>Applicant | >Tradename | >Biologic Ingredient | >Dosage Form | >BLA | >Approval Date | >Patent No. | >Expiredate |
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