Claims for Patent: 7,029,713

Summary for Patent: 7,029,713

Title:	Peptide extract of lupine and pharmaceutical or cosmetic or nutritional composition comprising the same
Abstract:	The invention concerns a peptide extract of lupine (lupinus) characterised in that it has a metalloprotease inhibiting activity, in particular collagenase and gelatinase. The invention also concerns a pharmaceutical, cosmetic or nutritional composition comprising a peptide extract, optionally an inert carrier, in particular for treating humans or mammals suffering from a condition or disease related to excessive degeneration of support by a metalloprotease.
Inventor(s):	Msika; Philippe (Paris, FR), Piccirilli; Antoine (Epernon, FR), Paul; Francois (Toulouse, FR)
Assignee:	Laboratoires Pharmascience (Courbevoie Cedex, FR)
Application Number:	10/678,884
Patent Claims:	1. A method of treating a condition or disease linked to degradation of collagen or another extracellular support macroprotein in a mammal, comprising topically administering a composition comprising an effective amount of an enzymatically hydrolyzed peptide extract of lupin to the mammal. 2. The method of claim 1 wherein the condition or disease is neoangiogenesis, psoriasis, a tumor, erythosis, acne erythemotosa, rosacea, arthrosis, parodontosis, a periodontal disease, a skin lesion, an inflammatory disease, a cicatrization deficiency, an ulcer, a burn, a blistering disease, or an attack of dental enamel. 3. The method of claim 2 wherein the condition or disease is a skin lesion due to aging, or a skin lesion caused by solar radiation, tobacco use, pollution or stress. 4. The method of claim 1 wherein the composition inhibits metalloprotease activity when administered to the subject. 5. The method of claim 1 wherein the composition inhibits collagenase activity, gelatinase activity or stromelysin activity when administered to the subject. 6. The method of claim 1 wherein the hydrolyzed peptide extract of lupin is a hydrolyzed extract of a sweet white lupin. 7. The method of claim 6 wherein the hydrolyzed peptide extract of the sweet white lupin is a hydrolyzed extract of an Ares variety of sweet white lupin. 8. The method of claim 1 wherein the mammal is a human. 9. A method of inhibiting metalloprotease activity in a mammal, comprising topically administering an effective amount of an enzymatically hydrolyzed peptide extract of lupin to the mammal. 10. The method of claim 9, wherein the metalloprotease activity is collagenase activity, gelatinase activity or stromelysin activity. 11. The method of claim 9 wherein the hydrolyzed peptide extract of lupin is a hydrolyzed extract of a sweet white lupin or a hydrolyzed extract of an Ares variety of sweet white lupin. 12. The method of claim 9 wherein the mammal is a human.

Details for Patent 7,029,713

Applicant	Tradename	Biologic Ingredient	Dosage Form	BLA	Approval Date	Patent No.	Expiredate
Smith & Nephew, Inc.	SANTYL	collagenase	Ointment	101995	06/04/1965		2019-04-19